Results 51 to 60 of about 2,527,170 (342)

Inhibition of CDK9 enhances AML cell death induced by combined venetoclax and azacitidine

Molecular Oncology, EarlyView.
The CDK9 inhibitor AZD4573 downregulates c‐MYC and MCL‐1 to induce death of cytarabine (AraC)‐resistant AML cells. This enhances VEN + AZA‐induced cell death significantly more than any combination of two of the three drugs in AraC‐resistant AML cells.
Shuangshuang Wu, Jianlei Zhao, Aaban Asfar Azmi, Avanti Gupte, Jenna Thibodeau, Shuang Liu, Jinli Yang, Guan Wang, Holly Edwards, Lisa A. Polin, Juiwanna Kushner, Sijana H. Dzinic, Kathryn White, Julie Boerner, Maik Hüttemann, Jay Yang, Yue Wang, Jeffrey W. Taub, Yubin Ge   +18 more
wiley   +1 more source

Health effects of housing improvements [PDF]

, 2015
Despite long-established associations between housing conditions and health, the evidence linking housing improvements to changes in health outcomes is still sparse. Our latest briefing paper, Health Effects of Housing Improvements, reports on changes in
Curl, Angela
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Fire retardant treatment of low contamination for panels made from recycled plastic films and polyester resin

Cogent Engineering, 2017
The aim of this research was to propose a fire retardant treatment with low contamination additives for panels manufactured with recycled plastics from packaging of food industries and polyester resin.
Gaggino Rosana, Kreiker Jerónimo
doaj   +1 more source

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

Challenges in public housing provision in the post independence era in Nigeria [PDF]

, 2011
This study investigated the contextual and organizational challenges in public housing provision in Nigeria in the post independence era. It was motivated by dearth of empirical studies on organizational challenges in public housing in this country ...
Anosike, N. M,, Azuh, Dominic E., Ibem, Eziyi O.   +2 more
core   +2 more sources

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Evaluation of Fire Hazard and Safety Management of Heritage Buildings in Georgetown, Penang

MATEC Web of Conferences, 2014
Fire is a subject that is always neglected and ignored as far as heritage buildings are concerned. Unlike newly-built buildings, which are required under UBBL to undergo certain fire protection system tests, people are less likely to carry out such tests
Othuman Mydin M.A., Sani N. Md, Abas N.F., Khaw Y.Y.   +3 more
doaj   +1 more source

Glycosylated LGALS3BP is highly secreted by bladder cancer cells and represents a novel urinary disease biomarker

Molecular Oncology, EarlyView.
Urinary LGALS3BP is elevated in bladder cancer patients compared to healthy controls as detected by the 1959 antibody–based ELISA. The antibody shows enhanced reactivity to the high‐mannose glycosylated variant secreted by cancer cells treated with kifunensine (KIF).
Asia Pece, Giulio Lovato, Ilaria Cela, Arianna Mercatelli, Benedetta Ferro, Jussi Nikkola, Sara Pagotto, Tommaso Grottola, Vincenzo De Laurenzi, Rossella Cicchetti, Antonio Marchetti, Luigi Schips, Rossano Lattanzio, Stefano Iacobelli, Emily Capone, Peter Black, Mads Daugaard, Michele Marchioni, Gianluca Sala   +18 more
wiley   +1 more source

Ecoso exchange newsletter : ecological, sociological and political discourse 2/44; June 1997 [PDF]

, 1997
This is a special edition on public housing in Victoria 1937 to 1997. Contents: Page 2. The Tenants Councils (1937 to 1950) 5. The HCV's First Thirty Years (1937/8 to 1967) 9. Community Housing ? Public Housing ? (issues of the 90's) 10.

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Determining the Compressive, Flexural and Splitting Tensile Strength of Silica Fume Reinforced Lightweight Foamed Concrete

MATEC Web of Conferences, 2014
This study investigated the performance of the properties of foamed concrete in replacing volumes of cement of 10%, 15% and 20% by weight. A control unit of foamed concrete mixture made with ordinary Portland cement (OPC) and 10%, 15% and 20% silica fume
Mydin M.A.O., Sani N. Md., Mohd Yusoff M.A., Ganesan S.   +3 more
doaj   +1 more source