Results 31 to 40 of about 934,795 (307)

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

Evaluation of common defects of grouted sleeve connectors

Case Studies in Construction Materials, 2022
Grouted sleeve connectors have been widely used in vertical connections of prefabricated reinforced concrete structures. However, the quality of grouted sleeve connections are likely affected by adverse factors during winter construction such as grouting
Tan Wang, Zhijie Zhou, Kuo Yuan, Ruinian Jiang, Xianqian Ma, Liwei Li   +5 more
doaj   +1 more source

Cost-Effective Housing Technology with Carbon Neutral Blocks [PDF]

E3S Web of Conferences, 2020
Conventional materials are considered to be major contributors of Green House Gas (GHG) emissions. New cost effective technologies for housing is, therefore, a need of the hour.
Sudom Narsing Rao, Ravande Kishore
doaj   +1 more source

Creating Age-Friendly Communities: Housing and Technology [PDF]

Healthcare, 2019
Taking an international perspective of healthy ageing, people are living longer and are generally in better health than previous generations [...]
van Hoof, Joost, Marston, Hannah R., Brittain, Katie R., Barrie, Helen R.   +3 more
openaire   +4 more sources

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Requalificação de “vilas urbanas” e governança cooperativa na questão habitacional para populações flutuantes: Evidências de grandes cidades chinesas

RAE: Revista de Administração de Empresas
As vilas urbanas são um tipo de área urbana em declínio na China, marcada por aluguéis de baixo custo e por sua localização favorável a uma população flutuante.
Xizan Jin, Lili Chen, Jiale Zhou, Qinlong Zhou, Song Wang   +4 more
doaj   +1 more source

The Feasibility of Using Marble Cutting Waste in a Sustainable Building Clay Industry

Recycling, 2018
This study evaluates the feasibility of stabilizing clay bricks with marble cutting waste (MCW). This waste is currently discarded in huge quantities as sludge resulting from the sawing of marble blocks to slabs and the processes of disposing of grinding
Medhat S. El-Mahllawy, Ayman M. Kandeel, Mahmoud L. Abdel Latif, Abdeen M. El Nagar   +3 more
doaj   +1 more source

EFFICIENCY OF TABLE EGG PRODUCTION IN DIFFERENT HOUSING SYSTEMS AND FARM SIZES: A CASE STUDY BASED ON THREE HUNGARIAN FARMS [PDF]

Annals of the Polish Association of Agricultural and Agribusiness Economists, 2019
In the European Union, alternative housing systems (aviary, barn, free-range, organic) are increasingly used in laying hen populations (49.6%). Hungary is one of the member states where modified cage housing technology is prevalent, but this may change ...
Adél Dorottya Erdős, Szilvia Molnar, László Szőllősi   +2 more
doaj   +1 more source

The governance of innovation in socio-technical systems: the difficulties of strategic niche management in practice [PDF]

, 2007
Strategic niche management concerns how governments can foster the introduction of new technologies, initially through establishing experiments within protected niches.
Lovell, Heather
core   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source