Results 1 to 10 of about 44,575 (191)

Functions of HP1 proteins in transcriptional regulation

Epigenetics & Chromatin, 2022
In eukaryotes, DNA is packaged into chromatin, which presents significant barriers to transcription. Non-histone chromatin proteins such as the Heterochromatin Protein 1 (HP1) proteins are critical regulators of transcription, contributing to gene ...
John M. Schoelz, Nicole C. Riddle
doaj   +3 more sources

HP1 loses its chromatin clustering and phase separation function across evolution [PDF]

Nature Communications
Heterochromatin protein 1 (HP1) is a multifunctional chromatin-associated protein conserved from fission yeast to mammals. HP1 has been suggested to drive heterochromatin formation via phase separation.
Sanâa Bensaha, Dominika Lewandowska, Fernando Muzzopappa, Stephanie Hutin, Mark D. Tully, Michela Anfossi, Florence M. Cammas, Christophe Normand, Fabian Erdel   +8 more
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HP1-Mediated Silencing of the Doublesex1 Gene for Female Determination in the Crustacean Daphnia magna [PDF]

Journal of Developmental Biology
The crustacean Daphnia magna produces genetically identical females and males by parthenogenesis. Males are produced in response to environmental cues including crowding and lack of food.
Junya Leim, Nikko Adhitama, Quang Dang Nong, Pijar Religia, Yasuhiko Kato, Hajime Watanabe   +5 more
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Virocell resource manipulation under nutrient limitation [PDF]

mSystems
Virus-infected cells, called virocells, impact host metabolic functions, resources, and ecosystem processes, but the effects of nutrient limitation remain less well understood.
Morgan M. Lindback, Cristina Howard-Varona, Jane Fudyma, Malak Tfaily, Matthew B. Sullivan, Melissa B. Duhaime   +5 more
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The effects of Non3 mutations on chromatin organization in Drosophila melanogaster [PDF]

Вавиловский журнал генетики и селекции
The nucleolus is a large membraneless subnuclear structure, the main function of which is ribosome biogenesis. However, there is growing evidence that the function of the nucleolus extends beyond this process.
A. A. Yushkova, A. A. Ogienko, E. N. Andreyeva, A. N. Pindyurin, A. E. Letiagina, E. S. Omelina   +5 more
doaj   +2 more sources

On the relations of phase separation and Hi-C maps to epigenetics [PDF]

Royal Society Open Science, 2020
The relationship between compartmentalization of the genome and epigenetics is long and hoary. In 1928, Heitz defined heterochromatin as the largest differentiated chromatin compartment in eukaryotic nuclei.
Prim B. Singh, Andrew G. Newman
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High-resolution mapping reveals links of HP1 with active and inactive chromatin components. [PDF]

PLoS Genetics, 2007
Heterochromatin protein 1 (HP1) is commonly seen as a key factor of repressive heterochromatin, even though a few genes are known to require HP1-chromatin for their expression.
Elzo de Wit, Frauke Greil, Bas van Steensel   +2 more
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Endogenous Retroviral Sequences Behave as Putative Enhancers Controlling Gene Expression through HP1-Regulated Long-Range Chromatin Interactions

Cells, 2022
About half of the mammalian genome is constituted of repeated elements, among which endogenous retroviruses (ERVs) are known to influence gene expression and cancer development.
Sébastien Calvet, Séphora Sallis, Nehmé Saksouk, Cosette Rebouissou, Catherine Teyssier, Annick Lesne, Florence Cammas, Thierry Forné   +7 more
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POF and HP1 bind expressed exons, suggesting a balancing mechanism for gene regulation. [PDF]

PLoS Genetics, 2007
Two specific chromosome-targeting and gene regulatory systems are present in Drosophila melanogaster. The male X chromosome is targeted by the male-specific lethal complex believed to mediate the 2-fold up-regulation of the X-linked genes, and the highly
Anna-Mia Johansson, Per Stenberg, Fredrik Pettersson, Jan Larsson   +3 more
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How HP1 Post-Translational Modifications Regulate Heterochromatin Formation and Maintenance

Cells, 2020
Heterochromatin Protein 1 (HP1) is a highly conserved protein that has been used as a classic marker for heterochromatin. HP1 binds to di- and tri-methylated histone H3K9 and regulates heterochromatin formation, functions and structure.
Raquel Sales-Gil, Paola Vagnarelli
doaj   +1 more source