Results 101 to 110 of about 44,575 (191)
Destabilizing Heterochromatin: Does Swi6/HP1 Make the Choice? [PDF]
Molecular Cell, 2006 HP1 is well known as a key silencing protein. However, in the June 9 issue of Molecular Cell, report that Swi6/HP1 recruits an antisilencing protein, Epe1, to facilitate transcription, leading to a model in which Swi6/HP1 is used as a platform to recruit both silencing and antisilencing activities.
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Word Sense Disambiguation by Web Mining for Word Co-occurrence Probabilities [PDF]
, 2004 This paper describes the National Research Council (NRC) Word Sense Disambiguation (WSD) system, as applied to the English Lexical Sample (ELS) task in Senseval-3.
Turney, Peter D.
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PLoS ONE, 2019 Durable gene silencing through the formation of compact heterochromatin domains plays a critical role during mammalian development in establishing defined tissues capable of retaining cellular identity.
Patricia A Vignaux +2 more
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Stemness factor Sall4 is required for DNA damage response in embryonic stem cells. [PDF]
, 2015 Mouse embryonic stem cells (ESCs) are genetically more stable than somatic cells, thereby preventing the passage of genomic abnormalities to their derivatives including germ cells. The underlying mechanisms, however, remain largely unclear. In this paper,
Briggs, Steven P +7 more
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Mechanistic Analysis of HP1 heterochromatin assembly
The FASEB Journal, 2013 The most conserved form of heterochromatin is characterized by methylation of lysine 9 on histone H3 (H3K9me3). Key to both the assembly and the spreading process is the heterochromatin protein 1 (HP1), which binds the H3K9me3 mark via its chromodomain (CD).
Geeta Narlikar +9 more
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New Partners for HP1 in Transcriptional Gene Silencing [PDF]
Molecular Cell, 2011 A new study in this issue of Molecular Cell (Yamane et al., 2010) demonstrates how chromatin assembly proteins HIRA/Asf1 help enforce transcriptional gene silencing in heterochromatin by bridging interactions between HP1 and histone deacetylase complexes.
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Microbial Cell, 2014 Shigella flexneri, a gram-negative bacterium responsible of bacillary dysentery, uses multiple strategies to overcome host immune defense. We have decrypted how this bacterium manipulates host-cell chromatin binders to take control of immune gene ...
Habiba Harouz +4 more
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Intestinal permeability enhancement of benzopyran HP1-loaded nanoemulsions
European Journal of Pharmaceutical Sciences, 2019 The benzopyran HP1, a compound isolated from Hypericum polyanthemum, has demonstrated significant opioid-mediated antinociceptive activity after its oral administration. Despite the pharmacological potential, the poor aqueous solubility limits the oral absorption of this compound.
Gabriela C. Meirelles +5 more
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Frontiers in Bioscience-LandmarkBackground: α thalassemia/mental retardation syndrome X-linked (ATRX) serves as a part of the sucrose nonfermenting 2 (SNF2) chromatin-remodeling complex.
Erchen Zhang +4 more
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Nature Communications, 2016 Heterochromatin protein 1 (HP1), including HP1 α, β and γ, is a family of non-histone chromatin factors thought to be involved in chromatin organization.
Kyoko Hiragami-Hamada +19 more
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