Results 11 to 20 of about 44,575 (191)
Proceedings of the National Academy of Sciences, 2012 Pericentromeric heterochromatin formation is mediated by repressive histone H3 lysine 9 methylation (H3K9Me) and its recognition by HP1 proteins. Intriguingly, in many organisms, RNAi is coupled to this process through poorly understood mechanisms.
Rougemaille, Mathieu +8 more
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HP1B is a euchromatic Drosophila HP1 homolog with links to metabolism. [PDF]
PLoS ONE, 2018 Heterochromatin Protein 1 (HP1) proteins are an important family of chromosomal proteins conserved among all major eukaryotic lineages. While HP1 proteins are best known for their role in heterochromatin, many HP1 proteins function in euchromatin as well.
Benjamin B Mills +2 more
doaj +1 more source
Interaction of HP1 and Brg1/Brm with the globular domain of histone H3 is required for HP1-mediated repression. [PDF]
PLoS Genetics, 2009 The heterochromatin-enriched HP1 proteins play a critical role in regulation of transcription. These proteins contain two related domains known as the chromo- and the chromoshadow-domain.
Marc Lavigne +9 more
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Cell Reports, 2023 Summary: H3K9 methylation (H3K9me) marks transcriptionally silent genomic regions called heterochromatin. HP1 proteins are required to establish and maintain heterochromatin.
Melissa Seman +4 more
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Interaction of Heterochromatin Protein 2 with HP1 Defines a Novel HP1-Binding Domain [PDF]
Biochemistry, 2005 Heterochromatin Protein 2 (HP2) is a nonhistone chromosomal protein from Drosophila melanogaster localized principally in the pericentric heterochromatin, telomeres, and fourth chromosome, all regions associated with HP1. Mutations in HP2 can suppress position effect variegation, indicating a role in gene silencing and heterochromatin formation ...
Gena E, Stephens +3 more
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Cells, 2019 The family of heterochromatin protein 1 (HP1) isoforms is essential for chromatin packaging, regulation of gene expression, and repair of damaged DNA. Here we document that γ-radiation reduced the number of HP1α-positive foci, but not HP1β
Soňa Legartová +7 more
doaj +1 more source
HP1β is a biomarker for breast cancer prognosis and PARP inhibitor therapy. [PDF]
PLoS ONE, 2015 Members of the heterochromatin protein 1 family (HP1α, β and γ) are mostly associated with heterochromatin and play important roles in gene regulation and DNA damage response.
Young-Ho Lee +5 more
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European Journal of Entomology, 2005 The methylated H3 histone and heterochromatin protein 1 (HP1) are markers of heterochromatin in several eukaryotes possessing monocentric chromosomes. In order to confirm that these epigenetic markers of heterochromatin are evolutionary conserved, the ...
Federica BORSATTI, Mauro MANDRIOLI
doaj +1 more source
A role for Separase in telomere protection [PDF]
, 2016 Drosophila telomeres are elongated by transposition of specialized retroelements rather than telomerase activity and are assembled independently of the sequence. Fly telomeres are protected by the terminin complex that localizes and functions exclusively
Bosso, Giuseppe +9 more
core +1 more source
Heterochromatin protein 1 (HP1) proteins do not drive pericentromeric cohesin enrichment in human cells. [PDF]
PLoS ONE, 2009 Sister chromatid cohesion mediated by cohesin is essential for accurate chromosome segregation. Classical studies suggest that heterochromatin promotes cohesion, but whether this happens through regulation of cohesin remains to be determined ...
Angel Serrano +2 more
doaj +1 more source