Results 21 to 30 of about 44,575 (191)
The Drosophila histone variant H2A.V works in concert with HP1 to promote kinetochore-driven microtubule formation [PDF]
, 2015 Unlike other organisms that have evolved distinct H2A variants for different functions, Drosophila melanogaster has just one variant which is capable of filling many roles.
Cenci, Giovanni, Verni', Fiammetta
core +1 more source
Biophysical Properties of HP1-Mediated Heterochromatin [PDF]
Cold Spring Harbor Symposia on Quantitative Biology, 2019 Heterochromatin is a classic context for studying the mechanisms of chromatin organization. At the core of a highly conserved type of heterochromatin is the complex formed between chromatin methylated on histone H3 lysine 9 and HP1 proteins. This type of heterochromatin plays central roles in gene repression, genome stability, and nuclear mechanics ...
Sanulli, Serena +2 more
openaire +2 more sources
Structural basis of HP1/PXVXL motif peptide interactions and HP1 localisation to heterochromatin [PDF]
The EMBO Journal, 2004 HP1 family proteins are adaptor molecules, containing two related chromo domains that are required for chromatin packaging and gene silencing. Here we present the structure of the chromo shadow domain from mouse HP1beta bound to a peptide containing a consensus PXVXL motif found in many HP1 binding partners.
Thiru, A. +9 more
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Cell Reports, 2015 HP1 enrichment at pericentric heterochromatin is essential for proper chromosome segregation. While H3K9me3 is thought to be a major contributor to HP1 enrichment at pericentric domains, in mouse cells, the SUMO-protease SENP7 is required in addition to ...
Kelly Romeo +5 more
doaj +1 more source
A monoclonal antibody recognizing very late activation antigen-4 inhibits eosinophil accumulation in vivo. [PDF]
, 1993 Using an in vivo test system, the role of the β1 integrin very late activation antigen-4 (VLA-4) in eosinophil accumulation in allergic and nonallergic inflammatory reactions was investigated.
Lobb, RR +3 more
core +1 more source
Drosophila RISC component VIG and its homolog Vig2 impact heterochromatin formation. [PDF]
PLoS ONE, 2009 Heterochromatin formation plays an important role in gene regulation and the maintenance of genome integrity. Here we present results from a study of the D.
Elena Gracheva +2 more
doaj +1 more source
Characterization of a Novel Heterochromatin Protein 1 Homolog “HP1c” in the Silkworm, Bombyx mori
Insects, 2022 Heterochromatin protein 1 plays an important role in chromatin structure and gene expression regulation. Three HP1 genes have been found in Homo sapiens, and five HP1 genes have been reported in Drosophila melanogaster. On the other hand, in Bombyx mori,
Masato Hino +8 more
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Mitotic Mysteries: The Case of HP1 [PDF]
Developmental Cell, 2016 The role of Heterochromatin Protein-1 (HP1) during mitosis has been controversial. Two recent studies in Science and Developmental Cell, from Tanno et al. (2015) and Abe et al. (2016), suggest that the means of HP1 localization and its function at inner centromeres are altered in cancer cells with chromosomal instability.
Higgins, Jonathan M.G. +1 more
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Liquid droplet formation by HP1α suggests a role for phase separation in heterochromatin. [PDF]
, 2017 Gene silencing by heterochromatin is proposed to occur in part as a result of the ability of heterochromatin protein 1 (HP1) proteins to spread across large regions of the genome, compact the underlying chromatin and recruit diverse ligands.
Agard, David A +8 more
core +1 more source
Crystal Structure of the HP1-EMSY Complex Reveals an Unusual Mode of HP1 Binding [PDF]
Structure, 2006 Heterochromatin protein-1 (HP1) plays an essential role in both the assembly of higher-order chromatin structure and epigenetic inheritance. The C-terminal chromo shadow domain (CSD) of HP1 is responsible for homodimerization and interaction with a number of chromatin-associated nonhistone proteins, including EMSY, which is a BRCA2-interacting protein ...
Huang, Ying +2 more
openaire +2 more sources