Results 41 to 50 of about 185,243 (332)

Quantification of Doxycycline Hyclate in Tablets by HPLC–UV Method [PDF]

open access: yesJournal of Chromatographic Science, 2012
An accurate, sensitive, precise and rapid gradient reversed-phase high-performance liquid chromatographic method was successfully developed and validated for the determination of doxycycline hyclate in bulk drug and tablets. The best separation was achieved on a 250 × 4.6 mm, 5.0 µm particle size CN Luna column with water + 0.1% TFA-acetonitrile + 0.1%
Kogawa, Ana Carolina   +1 more
openaire   +3 more sources

A Comparative Study of Newly Developed HPLC-DAD and UHPLC-UV Assays for the Determination of Posaconazole in Bulk Powder and Suspension Dosage Form

open access: yesJournal of Analytical Methods in Chemistry, 2014
Objective. To develop and compare HPLC-DAD and UHPLC-UV assays for the quantitation of posaconazole in bulk powder and suspension dosage form. Methods. Posaconazole linearity range was 5–50 μg/mL for both assays. For HPLC-DAD assay, samples were injected
Dalia A. Hamdy, Tarek S. Belal
doaj   +1 more source

VALIDATION METHODS FOR QUANTITATIVE DETERMINATION OF 4,4'-DIMETHYL-7,7'-ETHYLENDIOXY-2H-1-DIBENZOPYRAN-2,2'-DIONE SUBSTANCE

open access: yesРазработка и регистрация лекарственных средств, 2019
Introduction. One of the most promising synthetic compounds of coumarin derivatives is immunacor-4,4'-dimethyl-7,7'-ethylenedioxy-2H-1-dibenzopyran-2,2'-dione. As a result of preclinical studies, it has been shown that it is promising in medical practice
C. B. Nguyen, A. Z. Abyshev
doaj   +1 more source

Degradation of reactive red 195 by selected bacteria from textile wastewater [PDF]

open access: yes, 2009
Four selected bacterial strains coded R1, R2, Rc and Rd were successfully isolated from raw textile wastewater. They were screened for their ability to degrade an azo dye of Reactive Red 195 on solid and in liquid dye-containing media.
Nawahwi, Mohd. Zaini
core  

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

open access: yesFEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li   +2 more
wiley   +1 more source

Determination of Benzene, Toluene and Xylene (BTX) Concentrations in Air Using HPLC Developed Method Compared to Gas Chromatography [PDF]

open access: yesInternational Journal of Occupational Hygiene, 2011
A new method for analysis of benzene, toluene, and xylene (BTX) using High Performance Liquid Chromatography-UV detection (HPLC-UV) is described and compared to the gas chromatography (GC) method.
Abdulrahman Bahrami   +3 more
doaj   +2 more sources

Persistence of chlorpropham (CIPC) in the concrete flooring of potato stores [PDF]

open access: yes, 2018
The loss of the sprout suppressant, chlorpropham (CIPC), to the fabric of potato stores is currently of concern due to the risk of potential cross contamination of other crops subsequently housed in these stores.
Briddon, Adrian   +5 more
core   +1 more source

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

open access: yesMolecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang   +3 more
wiley   +1 more source

Postnatal maturation of the glomerular filtration rate in conventional growing piglets as potential juvenile animal model for preclinical pharmaceutical research [PDF]

open access: yes, 2017
Adequate animal models are required to study the preclinical pharmacokinetics (PK), pharmacodynamics (PD) and safety of drugs in the pediatric subpopulation.
Croubels, Siska   +8 more
core   +3 more sources

The cooperative regulation of miR‐221 by APE1 and AUF1 impacts p27Kip1 defining a miR signature relevant for cervical cancer

open access: yesFEBS Open Bio, EarlyView.
A regulatory axis involving APE1, AUF1, and miR‐221 is proposed. Pri‐miR‐221 is processed by DROSHA and DICER to generate mature miR‐221, which targets p27Kip1 mRNA. APE1 and AUF1 compete for pre‐miR‐221 binding. Reduced APE1/AUF1 levels impair miR‐221 biogenesis, decrease p27Kip1 mRNA degradation, and promote cell cycle progression, chemoresistance ...
Matilde Clarissa Malfatti   +3 more
wiley   +1 more source

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