Results 131 to 140 of about 31,176 (296)

Pathogenesis and Therapy of Hermansky–Pudlak Syndrome (HPS)-Associated Pulmonary Fibrosis

Hermansky–Pudlak syndrome (HPS)-associated pulmonary fibrosis (HPS-PF) is a progressive lung disease that is a major cause of morbidity and mortality in HPS patients.
Yumeng Wu, Liming Zhou, Xiao Hu, Qiong Lin, Zhixiao Wei, Manhan Zhao   +5 more
core   +1 more source

Cation Diffusion‐Mediated Displaced Reaction‐Transformation in Green Steelmaking

Advanced Science, EarlyView.
The removal of O lattice atoms by environmental H2 at the surface of Fe3O4 results in Fe enrichment, driving the inward diffusion of Fe cations into the bulk. Through hopping between unoccupied and initially occupied sites, cation diffusion triggers a spatially displaced reaction‐transformation and drives subsequent dynamic phase transformations and ...
Guangyi Guo, Paul Paciok, Baptiste Bienvenu, Longqi Bai, Barak Ratzker, Marc Heggen, Xuyang Zhou, Dierk Raabe   +7 more
wiley   +1 more source

THE METODS OF ASOCIAL PHENOMENA CRITICAL REFLECTION IN MASS MEDIA

Sovremennye Issledovaniâ Socialʹnyh Problem, 2013
The novelty of the study is that the author first identifies the main methods of reflection and criticism of asocial phenomena in journalism. The introduced concept of “the methods of critical reflection” is identified." The features of method’s ...
Анастасия Ивановна Ложкина
doaj  

A Phosphorylation‐Induced Micellization Switch in the Low‐Complexity Domain of TDP‐43

Advanced Science, EarlyView.
Phosphorylation of TAR DNA‐binding protein's 43 kDa (TDP‐43) low‐complexity domain by casein kinase 1 delta (CK1δ) acts as a molecular switch, redirecting its self‐assembly from macroscopic phase separation toward finite‐sized, spherical block‐copolymer micelles of ∼30 nm.
Rodrigo F. Dillenburg, Anastasia Lopatina, Hao Ruan, Tom Scheidt, Simone Mosna, Emre Pekbilir, Julia Bieber, Frank Schäfer‐Depoix, Katharina Landfester, Carla Schmidt, Martin M. Möckel, Svenja Morsbach, Friederike Schmid, Dorothee Dormann, Lukas Stelzl, Martin Girard, Edward A. Lemke   +16 more
wiley   +1 more source

Therapeutic Gene Editing of APOE4 in Sporadic Alzheimer's Disease via Prime Editor 7

Advanced Science, EarlyView.
Prime Editor 7‐mediated conversion of APOE4 to APOE3 alleviates Alzheimer's disease‐associated pathology in AD mouse models and patient‐derived neurons and improves cognitive performance in vivo, supporting therapeutic genome editing as a promising strategy for APOE4‐associated neurodegeneration.
Yunkyung Kim, Gaeun Lee, Saemin An, Hanseul Park, Hongwon Kim, Jisung Kim, Soi Kang, Sumin Kim, Daeyeol Kwon, Jeonghyun Park, Yerim Hwang, Seonghun Kim, Xiuwen Yuan, Jaehoon Jeong, Hamin Lee, Hui Kwon Kim, Jongpil Kim   +16 more
wiley   +1 more source

Stabilized Cubic GeTe With Matched Grain‐Boundary Networks and Band Convergence for High‐Performance Dual‐Mode Thermoelectric Devices

Advanced Science, EarlyView.
I‐doping stabilizes the cubic phase of GeTe and generates “electron‐transparent, phonon‐blocking” grain boundary networks while inducing valence‐band convergence. This synergistic structural‐electronic design enables effective electron‐phonon decoupling, achieving an exceptional average zTave of ∼1.62, a peak zT of ∼2.2, and enhanced mechanical ...
Xiaobo Tan, Xuri Rao, Huangshui Ma, Jiaxing Luo, Fan Feng, Zijian Lin, Ruiheng Li, Maoji Tian, Siqi Huo, Min Hong, Ran Ang   +10 more
wiley   +1 more source

A Second Pathogenic Protein, PolyGN2C‐iso2, Reveals a Dual‐Protein Pathology in Neuronal Intranuclear Inclusion Disease

Advanced Science, EarlyView.
This study reveals that NOTCH2NLC transcript variant 2 generates PolyGN2C‐iso2, an aggregating protein present within intranuclear inclusions of NIID patient tissues. A novel mouse model expressing PolyGN2C‐iso2 recapitulates white matter abnormalities and cognitive deficits, mechanistically linked to mitochondrial dysfunction. These findings support a
Kang Zhang, Wenhao Ma, Yi Zhou, Zhijie Wu, Pan Gao, Hongze Niu, Hongfei Tai, Tianyi Zhao, Zheyue Dong, Li Li, Yan Zhang, An Wang, Si Shen, Yueyang Li, Sifei Yu, Yan Peng, Wang Sheng, Xiaoyan Dong, Hua Pan, Kaibin Shi, Magdalena J. Koziol, Xiaobing Wu, Zaiqiang Zhang   +22 more
wiley   +1 more source

PRÁTICAS EDUCATIVAS PRESENTES NOS ESPAÇOS DE SOCIABILIDADE DA VILA BELA DA SANTÍSSIMA TRINDADE E VILA REAL DO SENHOR BOM JESUS DE CUIABÁ (1748-1822)

e-Hum: Revista das Áreas de Humanidade do Centro Universitário de Belo Horizonte, 2012
RESUMO:Este artigo integra parte da discussão da tese que estou elaborando junto ao Instituto de Educação – Programa de Pós-Graduação em Educação (PPGE) - da Universidade Federal de Mato Grosso (UFMT), cujo objeto de estudo é as práticas educativas ...
Nileide Souza Dourado, Dr. Nicanor Palhares Sá   +1 more
doaj  

Probing Electrocatalyst Design for Product Selectivity in CO2 Reduction

Advanced Science, EarlyView.
Selective CO2 electroreduction is controlled by catalyst structure, dynamic surface reconstruction, adsorbate interactions, and reaction microenvironment. This review summarizes Cu‐ and non‐Cu‐based catalysts, single‐atom and molecular systems, degradation pathways, and operando/computational strategies for steering CO2RR toward hydrocarbons ...
Suvodeep Sen, Bapan Biswas, Apinya Ngoipala, Julia Wiktor, Ujjwal Pal, Shalini Singh   +5 more
wiley   +1 more source

Hepassocin prevents age-related liver senescence and facilitates liver regeneration by activating AMPK. [PDF]

Signal Transduct Target Ther
Yang Y, Chen H, Xiang S, Wei Y, Zhang L, Sun A, E X, Wu F, Luo N, Liang F, Wu X, Wang C, Chen Z, Zhang Q, Chen X, Wu Q, Han Z, Li C, Yin R, Ren G, Li J, Zhao K, Gao H, Wang R, Yu M, Yang X.   +25 more
europepmc   +1 more source