Results 151 to 160 of about 74,087 (340)

TRAP5 Inhibition Targeting Scar‐Associated Macrophages Ameliorates Acute Kidney Injury to Chronic Kidney Disease Transition

open access: yesAdvanced Science, EarlyView.
This study delineates macrophage heterogeneity along the acute kidney injury to chronic kidney disease transition. Single‐cell RNA sequencing reveals a TRAP5+ scar‐associated macrophage subset driven by Spp1–Cd44 signaling and mitochondrial metabolic reprogramming.
Chenxi Wang   +13 more
wiley   +1 more source

Hp uzayları

open access: yes, 2020
This thesis consist of four chapters. The first chapter is devoted to the introduction. In the second chapter, the Hp classes are defined and the topological structure of Hp classes is investigated. Then continuous linear functionals on Hp are determined and common properties of Hp spaces and Bp spaces arc given.
openaire   +1 more source

Development and Structural Characterization of UTE‐156, a Covalent Inhibitor of the VCP/p97 AAA+ ATPase

open access: yesAdvanced Science, EarlyView.
The AAA+ ATPase Valosin‐containing protein (VCP/p97) regulates protein homeostasis by unfolding ubiquitinated substrates. Here, we describe UTE‐156, a novel irreversible covalent inhibitor that modifies Cys522 in the D2 ATPase motor domain. Although its pharmacochemical limitations preclude immediate therapeutic use, UTE‐156 serves as a valuable ...
Daniela Tamayo‐Jaramillo   +8 more
wiley   +1 more source

Nanoscale Spatial Organization of ARC High‐ and Low‐Order Assemblies at Excitatory Synapses

open access: yesAdvanced Science, EarlyView.
ARC (Activity‐Regulated Cytoskeleton‐Associated protein) mediates synaptic plasticity by forming nanoscale assemblies in neurons. Using super‐resolution microscopy and time‐resolved anisotropy with targeted tagging, the study reveals low‐order ARC assemblies at synapses colocalizing with AMPARs, semi‐circular structures at endocytic zones, and 60–80 nm
Martina Damenti   +13 more
wiley   +1 more source

The Importance of Liver-Lung Communication in Pulmonary Vascular Diseases. [PDF]

open access: yesCompr Physiol
Singh N   +8 more
europepmc   +1 more source

Hierarchical MXene/ZnO Nanorods: WO3/CNT Trilayer Coatings on Cotton for High‐Performance Multifunctional Wearable Fabrics

open access: yesAdvanced Science, EarlyView.
xx xx. ABSTRACT Fabric‐based wearable electronics are gaining increasing attention owing to their flexibility, breathability, biocompatibility, and seamless integration into clothing. However, most existing studies rely primarily on metallic or carbon‐based conductive materials.
Thirumalaisamy Suryaprabha   +6 more
wiley   +1 more source

Hierarchical Channeled Graphitized Nanoarchitecture as a Diagnostic Platform for Maternal Fever Warning

open access: yesAdvanced Science, EarlyView.
This study presents a hierarchically channeled graphitized nanoarchitecture (HPGC‐Z67) as a novel nano‐diagnostic platform. It enables sensitive and efficient N‐glycan extraction from plasma, significantly reducing processing time and cost. The platform identifies pivotal N‐glycans to accurately differentiate between infectious and non‐infectious ...
Yiwen Lin   +5 more
wiley   +1 more source

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