Results 161 to 170 of about 192,544 (305)

Enhanced CRISPR‐cas systems for genome editing and molecular diagnostics

Interdisciplinary Medicine, EarlyView.
This review systematically summarizes the major optimization strategies for CRISPR‐Cas systems, focusing on the engineering of Cas proteins, guide RNAs, reporter probes, and the incorporation of chemical additives. The aim is to enhance editing precision and diagnostic capability, thereby expanding the CRISPR system's potential for broader biomedical ...
Sheng Li, Han Li, Bojie Chen, Ling Jiang, Keyu Long, Jiaqi Lang, Xingxiang Pu, Erhu Xiong   +7 more
wiley   +1 more source

Combined Assessment of HPV and p16 Optimizes Clinical Decision-Making in Head and Neck Cancer of Unknown Primary. [PDF]

Cancer Med
Jörtsö E, Näsman A, Schliemann I, Zupancic M, Sivars L, Dalianis T, Marklund L, Bark R.   +7 more
europepmc   +1 more source

Organ‐Specific Human Microbiomes and Dysbiosis: Mechanistic Links to Disease and Emerging Therapeutic Strategies

Journal of Clinical Laboratory Analysis, EarlyView.
Schematic overview of the human microbiome and major microbiota‐derived metabolites across body sites, highlighting the gut–brain, gut–heart, and gut–kidney axes in host physiology and disease. ABSTRACT Background The human microbiome is a dynamic and diverse community of microorganisms that affects susceptibility to illness and promotes wellness ...
Awadh Alanazi
wiley   +1 more source

Human papillomavirus (HPV) and HPV vaccine awareness in Indigenous communities in Northwest Territories, Canada. [PDF]

PLoS One
Omidimorad A, Kolahdooz F, Kolahdooz G, Wagg A, Veugelers P, Corriveau A, Kandola K, Irlbacher-Fox S, Ogilvie G, Gotay C, Sharma S.   +10 more
europepmc   +1 more source

Anticancer potential of berberine: Molecular pathways and current clinical trial perspectives

JSFA reports, EarlyView.
Abstract Cancer is constantly rising mortality rates due to its late prognosis, poor management, and expensive treatment. Multi‐sectoral approaches for cancer management include hygienic practices, synthetic drug exploitation, radiation therapy, and diet modifications.
Muhammad Maaz, Muhammad Tauseef Sultan, Muhammad Israr, Waqas Ahmad Khan, Fahad Tanveer, Muzzamal Hussain, Muhammad Imran, Ahmed Mujtaba, Anjuman Gul Memon, Muhammad Atif, Entessar Al Jbawi   +10 more
wiley   +1 more source

Cervical leukoplakia in Ghana: Unveiling diagnostic challenges and informing low-resource screening strategies. [PDF]

PLoS One
Effah K, Tekpor E, Afetor M, Amuah JE, Wormenor CM, Dugbazah AE, Danyo S, Kemawor S, Sesenu E, Nyamekye C, Donkoh ET, Kubio C, Adum-Attah K.   +12 more
europepmc   +1 more source

Transoral Robotic Surgery in Head and Neck Oncology: A Scoping Review of Evidence, Technological Advancements, and Future Trajectories

Journal of Surgical Oncology, EarlyView.
ABSTRACT Robotic surgery has transformed head and neck cancer (HNC) treatment. This scoping review synthesizes evidence on transoral robotic surgery (TORS), focusing on applications, limitations, and future directions. Following PRISMA‐ScR guidelines, this review used the PCC framework (Population: HNC patients; Concept: technological advancements ...
Anna Luíza Damaceno Araújo, Karthik N. Rao, Juan P. Rodrigo, Vincent Vander Poorten, Orlando Guntinas‐Lichius, Alfio Ferlito, Luiz Paulo Kowalski   +6 more
wiley   +1 more source

HPV genotype distribution and associated risk factors in women from Karad, Maharashtra: A molecular characterisation study. [PDF]

Indian J Med Res
Deshmukh VN, Patil SR, Hinge DD, Jadhav PS.   +3 more
europepmc   +1 more source

Genotype distribution of high-risk and potential high-risk HPV types among women in different screening and clinic settings in Ghana and Kenya. [PDF]

PLoS One
Kwesi-Maliepaard EM, Osea-Larbi JA, Nyamari CK, Alhassan Y, Sromani AK, Kotey VM, Darko S, Tackie R, Kiome R, Mohammed AM, Buadii E, Quaye EK, Akligoh H, Ibrahim BA, Kaba P, Amoako SF, Kotey E, Agyemang S, Ngoi JM, Paemka L, Darkwa K, Degley T, Siebu NE, Olwal CO, Morang'a CM, Manu A, Hutchful D, Amoako E, Onyambu FG, Bediako Y.   +29 more
europepmc   +1 more source

Therapeutic Challenges in Managing Coexisting Hidradenitis Suppurativa and Squamous Cell Carcinoma: A Clinical Case Study

JEADV Clinical Practice, EarlyView.
ABSTRACT Hidradenitis suppurativa (HS) is a chronic inflammatory skin disorder affecting intertriginous areas. Long‐standing HS can undergo malignant transformation into squamous cell carcinoma (SCC), particularly in the perineal and gluteal regions. We report a 54‐year‐old man with severe, treatment‐refractory HS complicated by an aggressive verrucous
Michael Zolotas, Tereza Jakovljevicova, Kamran Ghoreschi, Kerstin Kusch, Marisa Klemp, Robert Sabat, Georgios Kokolakis   +6 more
wiley   +1 more source