Results 171 to 180 of about 198,913 (305)

Artificial Intelligence for Identifying Tumor‐Reactive CD8+ T Cells: Biological Principles, Computational Advances, and Future Directions

Med Research, EarlyView.
This review details a three‐stage paradigm shift for tumor‐reactive CD8+ T‐cell identification: decoding transcriptomic states, deciphering clonal functional efficacy, and molecular‐level therapeutic TCR design. Addressing translational hurdles and generative AI “scientific blind spots”—such as missing catch bonds—we present a visionary roadmap.
Chao Yang, Yingying Sun, Yan Zhang, Yifen Shi, Zhiwen Shi   +4 more
wiley   +1 more source

Organoid Coculture Models for Cancer Research and Immunotherapy

Med Research, EarlyView.
This review summarizes organoid coculture platforms, including submerged Matrigel culture, air–liquid interface, microfluidic/organoid‐on‐a‐chip, and 3D bioprinting, for reconstructing the tumor microenvironment to study tumor–stroma/immune crosstalk, evaluate immunotherapies, and enable drug screening.
Zhuo Yang, Huihui Yang, Guangxin Li, Guobang Liu, Zhulan Chen, Wenzhi Tian, Meiyang Huang, Xiaoling Liu, Yongsheng Zhao, Dong Chen   +9 more
wiley   +1 more source

Rethinking the tumor microbiome: Methodological challenges and a framework for rigorous research

mLife, EarlyView.
Abstract The intratumoral microbiome, as an essential component of the tumor microenvironment, has attracted increasing attention in recent years. The tumor microbiota displays an intricate interplay with its biological behaviors. However, emerging controversies, including the retraction of Poore et al.'s article, highlight significant challenges ...
Lingxuan Zhu, Zhixing Deng, Weiming Mou, Gengwen Deng, Hongyu Lu, Liling Xu, Shujia Lin, Hongsen Huang, Keren Wu, Qiheng Liang, Hao Li, Ziwen Zheng, Anqi Lin, Peng Luo   +13 more
wiley   +1 more source

Scaling HPV Self-Sampling in Low-Resource Settings: From Evidence to Sustainable Implementation. [PDF]

Int J Womens Health
Inturrisi F, Serrano B, de Sanjosé S.
europepmc   +1 more source

Nurse Navigation on Time to Postoperative Radiation Therapy after Transoral Robotic Surgery for Oropharyngeal Carcinoma

Otolaryngology–Head and Neck Surgery, EarlyView.
Abstract Objective Postoperative radiation therapy (PORT) initiation within 6 weeks of surgery is associated with improved oncologic outcomes in head and neck cancer, but delays remain common. Oncology nurse navigators (ONN) may improve care coordination.
Vera Bzhilyanskaya, Jane Y. Tong, Theresa Vetter‐Habighorst, Kelly Moyer, Jeffrey Wolf, Rodney Taylor, Jason K. Molitoris, Matthew J. Ferris, Ranee Mehra, Kyle M. Hatten   +9 more
wiley   +1 more source

Awake Blue Laser Excision and Balloon Dilation of Oropharyngeal Stenosis in High‐Risk Patients

Otolaryngology–Head and Neck Surgery, EarlyView.
Abstract Oropharyngeal stenosis is a rare condition that can develop following head and neck cancer treatment, leading to progressive dyspnea, dysphagia, and dysphonia. Patients with symptomatic dyspnea may benefit from endoscopic surgery. However, head and neck cancer survivors can have severe trismus, limited neck extension, and altered laryngeal ...
Abbey L. Landini, Cyrus W. Abrahamson, Andrew P. Stein   +2 more
wiley   +1 more source

The Audiologic and Otolaryngologic Phenotype in WHIM Syndrome

Otolaryngology–Head and Neck Surgery, EarlyView.
Abstract Objective WHIM syndrome (warts, hypogammaglobulinemia, infections, and myelokathexis syndrome) is an ultra‐rare primary immunodeficiency disease caused by autosomal dominant hyperfunctional mutations in the chemokine receptor CXCR4. Otolaryngologists are frequently consulted to evaluate WHIM patients because of recurrent acute ear and sinus ...
Christopher K. Zalewski, H. Jeffrey Kim, Carmen C. Brewer, Sophia Martinez, Caroline Rieger, Elena Cho, David H. McDermott, Philip M. Murphy   +7 more
wiley   +1 more source

Safety and Efficacy of the Versius Surgical System in Transoral Robotic Surgery: A Prospective Study

Otolaryngology–Head and Neck Surgery, EarlyView.
Abstract Objective To evaluate the safety and feasibility of the Versius surgical robotic system for transoral robotic surgery in benign and malignant head and neck indications. Study Design Open‐label, prospective, single‐arm, phase II clinical trial. Setting Liverpool Head and Neck Centre, United Kingdom. Methods Between December 2023 and March 2025,
Jason C. Fleming, Katharine Davies, Christopher Loh, Mark Wilkie, Xander Lawson, Saul Truckle, James Constable, Jennifer Gwinnutt, Jennifer Rodrigues, Paul Banks, Zoe Mellor, Terry M. Jones   +11 more
wiley   +1 more source

HPV vaccination coverage and barriers for people with disability: A scoping review. [PDF]

Hum Vaccin Immunother
Walmsley S, Vajdic CM, Bishop GM, Long R, Aitken Z.   +4 more
europepmc   +1 more source

Objective Swallowing Outcomes After Sparing Contralateral Low‐Neck Elective Radiotherapy in Oropharyngeal Carcinoma: Single‐Institution Clinical Experience

Otolaryngology–Head and Neck Surgery, EarlyView.
Abstract Objective Dysphagia is a major toxicity of chemoradiation (CRT) for oropharyngeal squamous cell carcinoma (OPSCC). Elective upper‐neck irradiation (UNI), omitting the low neck, may reduce esophageal inlet muscle (EIM) dose and improve swallowing outcomes compared to elective whole‐neck irradiation (WNI).
Rex H. Lee, Cara Evans, Sarah Honjo, Yue Ma, Alon Witztum, Patrick K. Ha, Sue S. Yom, Jason W. Chan   +7 more
wiley   +1 more source