Results 101 to 110 of about 45,353 (266)

Immune Repertoire Profiling Reveals Distinct Adaptive Immune Signatures of Dampness ZHENG Across Psoriasis, Rheumatoid Arthritis and Ulcerative Colitis

Cell Proliferation, EarlyView.
Schematic diagram for the experimental design for adaptome immune repertoire analysing Dampness ZHENG across Psoriasis, Rheumatoid Arthritis and Ulcerative Colitis. ABSTRACT Autoimmune diseases, including psoriasis (Ps), rheumatoid arthritis (RA) and ulcerative colitis (UC), pose significant health burdens worldwide.
Lipeng Tang, Maojie Wang, Yuhong Yan, Shumin Qin, Youbang Liang, Danni Yao, Liyan Mei, Hao Deng, Shuyan Ye, Xiumin Chen, Kaixin Gao, Xirun Zheng, Taohua Liu, Xinmin Qiu, Song Li, Xinjie Yu, Wenjing Pan, Shaogang Huang, Zhe Wang, Runyue Huang, Guangjuan Zheng, Chuanjian Lu   +21 more
wiley   +1 more source

Baseline Computed Tomography Coronary Angiography and Polygenic Risk Profiles in Adults With Type 2 Diabetes: A Cross‐Sectional Analysis From the VOLTAIRE Study

Diabetes, Obesity and Metabolism, EarlyView.
ABSTRACT Aims To characterise baseline clinical, anatomical, and genetic cardiovascular risk profiles in participants enrolled in the VOLTAIRE (Evaluation of Polygenic Scores and CT Imaging in Risk Factor Modification in Patients with Type 2 Diabetes) study and examine concordance across these domains. Methods This analysis included adults with T2D who
Ruofei (Trophy) Chen, Adam J. Nelson, Sophia Zoungas, Robyn A. Clark, Sean Tan, Esther F. Davis, Melissa C. Southey, Andrew Lin, Giuseppe Di Giovanni, Masashi Fujino, Jennifer Wong, Robert L. O'Reilly, Jacqueline S. Dron, Stephen J. Nicholls   +13 more
wiley   +1 more source

Intima‐Media Thickness Progression Rate and Primary Unassisted Patency Failure in Arteriovenous Fistulas: A Prospective Cohort Study

Hemodialysis International, EarlyView.
ABSTRACT Background Failure of autogenous arteriovenous fistulas (AV fistulas) due to venous neointimal hyperplasia is a major clinical challenge. Whether the rate of progression in venous intima‐media thickness predicts primary unassisted patency failure remains unknown.
Gen Li, Zhengjiang Cao
wiley   +1 more source

Periodontal Status of Type 1 Diabetes Mellitus and Healthy Pregnant Women: A Case–Control Pilot Study

International Journal of Dental Hygiene, EarlyView.
ABSTRACT Aims This cross‐sectional ‘case–control’ pilot study aimed to compare the size of periodontal wounds, periodontal status and total inflammatory burden between pregnant women with type 1 diabetes mellitus (T1DM) and non‐diabetic pregnant women. Methods Fifteen T1DM pregnant women and 15 healthy pregnant women were included. Clinical parameters (
M. Janc, M. Tomažič, M. Pirc, U. Skalerič, R. Schara   +4 more
wiley   +1 more source

Preliminary Validation of the Early Sacroiliitis Screening Tool (ESHST) for Identifying Hidradenitis Suppurativa Patients at High Risk of Spondyloarthritis

International Journal of Dermatology, EarlyView.
Development and preliminary validation of the Early Sacroiliitis Screening Tool (ESHST), a dermatology‐oriented screening questionnaire for identifying hidradenitis suppurativa patients at increased risk of spondyloarthritis. ABSTRACT Background Hidradenitis suppurativa (HS) is increasingly recognized as a systemic inflammatory disease associated with ...
Umut Bakay, Ozge Sevil Karstarli Bakay, Tugba Izci Duran, Niyazi Cetin   +3 more
wiley   +1 more source

Australian clinical practice guideline: diagnosis and treatment of idiopathic multicentric Castleman disease

Internal Medicine Journal, EarlyView.
Abstract Idiopathic multicentric Castleman disease (iMCD) is a rare condition. The pathogenesis is incompletely understood; however, interleukin‐6 (IL‐6) is a major mediator. The clinical presentation is heterogeneous, from mild constitutional symptoms to severe multi‐organ failure.
Dipti Talaulikar, Jun Yen Ng, Adam Bryant, Annmarie Bosco, Hugh C. Caterson, Pratyush Giri, Pravin Hissaria, Simon J. Harrison, Stephen Lade, Connull Leslie, Jacinta Perram, H. Miles Prince, Dejan Radeski, Maureen Rischmueller, Craig Wallington‐Gates, Nicholas Weber, Alberta Hoi   +16 more
wiley   +1 more source

Cholesterol accumulation in monocytes is associated with the severity of diabetic complications and the efficacy of glycemic control interventions in patients with type 2 diabetes

Journal of Diabetes Investigation, EarlyView.
This study reveals that monocyte cholesterol accumulation correlates with the severity of diabetic complications and predicts post‐discharge glycemic deterioration. These findings suggest that monocytic cholesterol serves as a novel translational biomarker reflecting ‘metabolic memory’ and therapeutic resistance in patients with type 2 diabetes ...
Hideyuki Okuma, Takahiro Tsutsumi, Asako Miyazaki, Kyoichiro Tsuchiya   +3 more
wiley   +1 more source

Elevated serum galectin‐3 levels predict the incidence of type 2 diabetes mellitus in a Japanese general population: A 10‐year follow‐up study

Journal of Diabetes Investigation, EarlyView.
Elevated serum galectin‐3 levels are associated with the incidence of T2DM independent of insulin resistance, particularly among non‐obese individuals. There may be a diabetogenic mechanism that is not mediated by obesity or insulin resistance. ABSTRACT Aims/Introduction Although several studies have reported elevated serum galectin‐3 levels in type 2 ...
Harumi Takubo‐Yoshimura, Mika Enomoto, Ako Fukami, Nagisa Morikawa, Yume Nohara‐Shitama, Hiromi Sato, Mayo Shimoyama‐Yamamoto, Hisashi Adachi, Yoshihiro Fukumoto   +8 more
wiley   +1 more source

Dapagliflozin does not impair microvascular hemorheology in type 2 diabetes mellitus: A multicenter randomized controlled trial (D‐PATH study)

Journal of Diabetes Investigation, EarlyView.
Graphical abstract illustrating the study design, physiological rationale, and key findings of the D‐PATH trial. Dapagliflozin, an SGLT2 inhibitor, lowers HbA1c and body weight while increasing hematocrit and erythropoietin levels. Although an elevated hematocrit could theoretically increase blood viscosity and impair microcirculatory flow, ex vivo ...
Yuki Nakatani, Nobuyuki Banba, Shoya Ono, Tomoki Turumi, Megumi Hoshiai, Takushi Sugiyama, Takashi Tomoe, Hajime Tamiya, Naoyuki Otani, Hiroyuki Sugimura, Hidekazu Ikemiyagi, Yusuke Ohya, Koji Yokokawa, Shinichiro Ueda, Yoshimasa Aso, Yasuhiro Maejima, Takanori Yasu   +16 more
wiley   +1 more source

Waist‐to‐height ratio and renal dysfunction as independent correlates of low handgrip strength in patients with type 2 diabetes

Journal of Diabetes Investigation, EarlyView.
In 1,468 patients with type 2 diabetes, central obesity (WHtR >0.5) neutralizes the protective effects of higher BMI on muscle strength. Concurrently, visceral adiposity and CKD impose an additive threat, maximizing low handgrip strength risk (aOR = 1.74). Combining WHtR and renal tracking optimizes clinical sarcopenia screening.
Shing‐Hua Chen, Chen‐Kai Chou, Shao‐Wen Weng, Jung‐Fu Chen, Feng‐Chih Shen   +4 more
wiley   +1 more source