Results 31 to 40 of about 593 (166)

Identification of atypical T4SS effector proteins mediating bacterial defense

open access: yesmLife, Volume 2, Issue 3, Page 295-307, September 2023., 2023
Abstract To remain competitive, proteobacteria use various contact‐dependent weapon systems to defend against microbial competitors. The bacterial‐killing type IV secretion system (T4SS) is one such powerful weapon. It commonly controls the killing/competition between species by secreting the lethal T4SS effector (T4E) proteins carrying conserved ...
Xi Shen   +11 more
wiley   +1 more source

An Antifungal Polycyclic Tetramate Macrolactam, Heat-Stable Antifungal Factor (HSAF), Is a Novel Oxidative Stress Modulator in Lysobacter enzymogenes. [PDF]

open access: yesAppl Environ Microbiol, 2021
PoTeMs are a family of structurally distinct metabolites that have been found in a large number of bacteria. Although PoTeMs exhibit diverse therapeutic properties, the physiological function of PoTeMs in the producer microorganisms had not been investigated.
Yu L, Li H, Zhou Z, Liu F, Du L.
europepmc   +4 more sources

Spatiotemporal variability in precipitation‐growth association of Betula nana in the Siberian lowland tundra

open access: yesJournal of Ecology, Volume 111, Issue 9, Page 1882-1904, September 2023., 2023
The association between secondary growth of Betula nana and precipitation in the Siberian lowland tundra is regulated by (i) macro‐ (kilometre‐scale) and micro‐topographical (metre‐scale) gradients, (ii) colimitation between temperature and moisture and (iii) nonlinear responses to precipitation extremes.
Rúna Í. Magnússon   +7 more
wiley   +1 more source

Interoperability among hospitals treating populations that have been marginalized

open access: yesHealth Services Research, Volume 58, Issue 4, Page 853-864, August 2023., 2023
Abstract Objective To test whether differences in hospital interoperability are related to the extent to which hospitals treat groups that have been economically and socially marginalized. Data Sources and Study Setting Data on 2393 non‐federal acute care hospitals in the United States from the American Hospital Association Information Technology ...
Jordan Everson   +3 more
wiley   +1 more source

Tundra Browning in the Indigirka Lowlands (North‐Eastern Siberia) Explained by Drought, Floods and Small‐Scale Vegetation Shifts

open access: yesJournal of Geophysical Research: Biogeosciences, Volume 128, Issue 7, July 2023., 2023
Abstract Contrary to the general “greening of the Arctic”, the Siberian Indigirka Lowlands show strong “browning” (a decrease in the Normalized Difference Vegetation Index or “NDVI”) in various recent satellite records. Since greening and browning are generally indicative of increases and losses in photosynthetically active biomass, this browning trend
Rúna Í. Magnússon   +4 more
wiley   +1 more source

Supramolecular Peptide Nanofiber Hydrogels for Bone Tissue Engineering: From Multihierarchical Fabrications to Comprehensive Applications

open access: yesAdvanced Science, Volume 9, Issue 11, April 14, 2022., 2022
This review proposes a novel concept to construct bone repair biomaterials based on supramolecular peptide nanofiber hydrogels, namely multihierarchical fabrications by structural design, biochemical functionalization, and mechanical optimization. Then, it discusses the comprehensive applications of supramolecular peptide nanofiber hydrogels for bone ...
Zhuowen Hao   +8 more
wiley   +1 more source

Coordinated control of the type IV pili and c‐di‐GMP‐dependent antifungal antibiotic production in Lysobacter by the response regulator PilR

open access: yesMolecular Plant Pathology, Volume 22, Issue 5, Page 602-617, May 2021., 2021
PilR phosphorylation mediated by PilS down‐regulates lchD expression via DNA binding to lower c‐di‐GMP synthesis and thus accumulate c‐di‐GMP‐free Clp, which activates heat‐stable antifungal factor production via DNA binding. Abstract In the soil gammaproteobacterium Lysobacter enzymogenes, a natural fungal predator, the response regulator PilR ...
Kangwen Xu   +5 more
wiley   +1 more source

Coordination of cyclic di-GMP and 4-hydroxybenzoic acid in regulating antifungal antibiotic biosynthesis in Lysobacter enzymogenes

open access: yesPhytopathology Research, 2020
Small molecules are able to regulate numerous cellular processes through binding to various bacterial receptor proteins, but the mechanisms and functions by which these chemicals coordinate and execute remain poorly understood.
Sen Han   +5 more
doaj   +1 more source

Functionalized peptide hydrogels as tunable extracellular matrix mimics for biological applications

open access: yesPeptide Science, Volume 113, Issue 2, March 2021., 2021
Abstract The development of tailorable and biocompatible three‐dimensional (3D) substrates or molecular networks that reliably mimic the extracellular matrix (ECM) and influence cell behavior and growth in vitro is of increasing interest for cell‐based applications in the field of tissue engineering and regenerative medicine.
Katharina S. Hellmund   +9 more
wiley   +1 more source

Control of glucosylceramide production and morphogenesis by the Bar1 ceramide synthase in Fusarium graminearum. [PDF]

open access: yesPLoS ONE, 2011
The contribution of plasma membrane proteins to the virulence of plant pathogenic fungi is poorly understood. Accordingly, the objective of this study was to characterize the acyl-CoA dependent ceramide synthase Bar1 (previously implicated in plasma ...
William R Rittenour   +3 more
doaj   +1 more source

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