Results 131 to 140 of about 111,857 (291)

Impact of organic pollutants on phenotype and gene expression in human breast cancer cells

Journal of Applied Toxicology, EarlyView.
ABSTRACT Human exposure to industrial chemical compounds is widespread and, although often beneficial, prolonged contact may contribute to disease development, including cancer. While many studies have shown organic pollutants (OP) are cytotoxic, few have explored how long‐term exposure alters cell phenotype.
Camila Confortin, Heloisa Amancio, Jessica Zablocki da Luz, Aliciane de Almeida Roque, Tugstênio Lima de Souza, José Eduardo Vargas, Ciro Alberto de Oliveira Ribeiro, Francisco Filipak Neto   +7 more
wiley   +1 more source

The Impact of Genotoxicity in Coke Oven Workers: Systematic Review With Meta‐Analysis

Journal of Applied Toxicology, EarlyView.
ABSTRACT This systematic review (SR) with meta‐analysis investigates the genotoxicity potential of coke oven workers (COWs) exposed to polycyclic aromatic hydrocarbons (PAHs) through a comprehensive analysis of studies retrieved from PubMed, SCOPUS, and Web of Science.
Thiago Guedes Pinto, Vinícius Fialho do Nascimento, Giovanna Abreu Holanda Guerra, Wilton Mitsunari Takeshita, Raquel Alves Sales, Andrea Cristina de Moraes Malinverni, Luciana Lopes Guimaraes, Daniel Araki Ribeiro   +7 more
wiley   +1 more source

Salt‐induced nutritional and metabolic shifts in halophytes: implications for food security

Journal of the Science of Food and Agriculture, EarlyView.
Abstract Plant species vary in their response to salinity: some crops show a degree of salt tolerance, while halophytes – whether wild or cultivated – are characterized by a high capacity to thrive under saline conditions. Halophytes are considered a source of valuable secondary metabolites with potential economic value, yet they might also produce ...
Giulia Atzori, Pedro Garcia Caparros, Antonella Castagna, Luisa Custódio, Valentina Lazazzara, Claus Krogh Madsen, Felicia Menicucci, Maria João Rodrigues, Katalin Solymosi, Jose Ramon Acosta Motos   +9 more
wiley   +1 more source

Lower Plasma Antioxidant Defense and Heat Shock Proteins Mark Intra‐Amniotic Sludge Ultrasound Finding

Journal of Ultrasound in Medicine, EarlyView.
Objectives Intra‐amniotic sludge is an independent risk factor for preterm birth. It consists of a biophysical sonographic finding in the amniotic fluid, formed by dense echogenic particles near the cervical internal orifice, due to sterile or infectious inflammatory processes.
Clarissa Chavez Ortiz Roberto, Lílian Corrêa Costa‐Beber, Lucas Machado Sulzbacher, Jaíne Borges dos Santos, Anna Karolina Kretschmann Florencio de Souza Bagetti, Eduardo Becker Jr, Matias Nunes Frizzo, Thiago Gomes Heck, Mirna Stela Ludwig   +8 more
wiley   +1 more source

Pulsed Electromagnetic Fields: A Novel Attractive Therapeutic Opportunity for Neuroprotection After Acute Cerebral Ischemia

Neuromodulation: Technology at the Neural Interface, EarlyView., 2021
Abstract Objectives Acute cerebral ischemia is characterized by several pathological processes evolving during time, which contribute to the final tissue damage. Secondary processes, such as prolonged inflammatory response, impaired mitochondrial function and oxidative stress, are responsible for the progression of brain injury to the peri‐infarct area,
Fioravante Capone, Simona Salati, Fabrizio Vincenzi, Micaela Liberti, Giorgio Aicardi, Francesca Apollonio, Katia Varani, Ruggero Cadossi, Vincenzo Di Lazzaro   +8 more
wiley   +1 more source

The HSP70 chaperone machinery: J proteins as drivers of functional specificity

Nature reviews. Molecular cell biology, 2010
H. Kampinga, E. Craig
semanticscholar   +1 more source

Oncogenic KRAS Rewires Stress Granule Dynamics: Mechanisms and Therapeutic Opportunities

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Stress granules (SGs) are dynamic, membrane‐less structures that form in response to various cellular stresses, including metabolic, oxidative, and therapeutic challenges. They function as adaptive hubs and reorganize protein synthesis and signaling networks to help cells survive under stress. In cancer, these condensates are often hijacked to
Msimisi Ndzinisa, Birhanetensay Masresha Altaye, Yuh‐Pyng Sher   +2 more
wiley   +1 more source

Calcium signaling in plant defense

New Plant Protection, EarlyView.
Calcium signaling acts as a central hub in plant immunity, translating pathogen perception into defense responses. This review highlights the channels, sensors, and signaling networks involved, and discusses how pathogens subvert calcium dynamics, as well as how this knowledge may inspire innovative strategies for engineering durable crop resistance ...
Lifan Sun, Yu Wang, Jie Zhang
wiley   +1 more source

Polymorphisms of HSP70 genes are involved in the pathogenesis of idiopathic inflammatory myopathy

Rheumatology
Introduction Idiopathic inflammatory myopathies (IIM) are a group of rare systemic autoimmune diseases characterized by muscle weakness, histopathological signs of inflammation in muscle tissues, elevated serum levels of muscle-associated enzymes ...
Tana Svitalkova, Antonin Ambroz, Marketa Svetla, Martina Misunova, Libor Kolesar, Peter Novota   +5 more
doaj   +1 more source

Disarming the Hsp70–Bim Alliance: Small‐Molecule and Peptidic Disruptors of a Chaperone‐Apoptotic Switch in Cancer

ChemistryOpen, EarlyView.
Targeting a nucleotide‐sensitive groove on Hsp70 that binds the Bim BH3 helix, we integrate structures, biophysics, and SAR from peptides, fragments, and phenalene‐dicarbonitrile “wedges.” These disrupt the Hsp70–Bim complex with sub‐µM cellular engagement and in vivo activity while sparing Hsp90/mortalin.
Emadeldin M. Kamel, Mohammed Al‐zharani, Lina M. Alneghery, Noha A. Ahmed, Faris F. Aba Alkhayl, Al Mokhtar Lamsabhi   +5 more
wiley   +1 more source