Results 211 to 220 of about 158,688 (339)

Investigating the Potential Role of Capsaicin in Facilitating the Spread of Coxsackievirus B3 via Extracellular Vesicles. [PDF]

Int J Mol Sci
Chatterjee S, Kordbacheh R, Tilley H, Briordy D, Waldron RT, Cutts WD, Aleman J, Cook A, Dhanji R, Wong LR, Pandol SJ, Kim BJ, Fairweather D, Sin J.   +13 more
europepmc   +1 more source

Compartmentalisation in cAMP signalling: A phase separation perspective

British Journal of Pharmacology, EarlyView.
Cells rely on precise spatiotemporal control of signalling pathways to ensure functional specificity. The compartmentalisation of cyclic AMP (cAMP) and protein kinase A (PKA) signalling enables distinct cellular responses within a crowded cytoplasmic space.
Milda Folkmanaite, Manuela Zaccolo
wiley   +1 more source

Heat shock proteins in osteoarthritis: molecular mechanisms, pathogenic roles, and therapeutic opportunities. [PDF]

Front Immunol
Zhao B, Deng Z, Yang Z, Yang F, Yang W.
europepmc   +1 more source

In silico identification of modulators of J domain protein-Hsp70 interactions in Plasmodium falciparum: a drug repurposing strategy against malaria

, 2023
Harpreet Singh, Shaikha Y. Almaazmi, Tanima Dutta, Robert A. Keyzers, Gregory L. Blatch   +4 more
openalex   +1 more source

Hot and Salty: Assessing ecological stress in New Hampshire streams at community, population, and molecular levels [PDF]

, 2018
Villamagna, Amy Marie
core   +1 more source

TbTim20 facilitates protein import at a low membrane potential in trypanosomes lacking the mitochondrial genome

The FEBS Journal, EarlyView.
Protein import into mitochondria relies on TIM complexes and the membrane potential. Trypanosoma brucei has a unique TIM complex, and the role of one subunit, TbTim20, has remained unclear. Here, we show that TbTim20 is essential in cells lacking mitochondrial DNA. The importance of TbTim20 increases as the membrane potential decreases.
Corinne von Känel, Salome Aeschlimann, Michaela Husová, Silke Oeljeklaus, Philip Stettler, Achim Schnaufer, Bettina Warscheid, Alena Zíková, André Schneider   +8 more
wiley   +1 more source

Genome-wide transcriptomic analysis reveals autophagy and HSP70-mediated mechanisms underlying thermal stress adaptation in Mytilus coruscus. [PDF]

BMC Genomics
Li C, Lv S, Jing H, Zhou H, Liu X.
europepmc   +1 more source

Specific Binding of Tetratricopeptide Repeat Proteins to Heat Shock Protein 70 (Hsp70) and Heat Shock Protein 90 (Hsp90) Is Regulated by Affinity and Phosphorylation

, 2015
Victoria A. Assimon, Daniel R. Southworth, Jason E. Gestwicki   +2 more
openalex   +1 more source

Functional Effects of ARV-1502 Analogs Against Bacterial Hsp70 and Implications for Antimicrobial Activity

, 2022
Alexandra Brakel, Lisa Kolano, Carl Kraus, László Ötvös, Ralf Hoffmann   +4 more
openalex   +1 more source

High levels of serum cholesterol increase the risk of developing vessel co‐opting tumors in colorectal cancer liver metastases

The FEBS Journal, EarlyView.
High serum cholesterol is linked to colorectal cancer liver metastases (CRCLM) subtypes with poor survival (replacement pattern). Levels of cholesterol under 4 mmol·L−1 correlated with better survival and a desmoplastic pattern subtype. Furthermore, in vivo PCSK9 inhibitor evolocumab, which lowers cholesterol, reduced liver metastases.
Amatzia Gantz, Audrey Kapelanski‐Lamoureux, Miran Rada, Lucyna Krzywon, Migmar Tsamchoe, Anastasia Tsatoumas, Stephanie K. Petrillo, Nabil G. Seidah, Anthoula Lazaris, Peter Metrakos   +9 more
wiley   +1 more source