氧化应激在阿尔茨海默病病理发生中的作用机制与干预策略 [PDF]
, 2020 阿尔茨海默病（AD）是常见的神经变性病，氧化应激在AD 早期病理发生和发展中起到了重要的作用。在老化、早老素 1（PS1）突变及环境等共同作用下，脑内出现过度氧化应激，促进β-淀粉样蛋白（Aβ）的形成，Aβ可能为氧化应激作用下的适应性产物。氧自由基产生与清除的失衡还可导致海马神经元自噬功能异常，诱导细胞从自噬到死亡，其可能的机制是Notch1 通路失调。Notch1 通路的失调导致机体抗氧化应激能力丧失和淀粉样前体蛋白（APP）剪切增多、Aβ沉积，最终引起AD 病理的发生与发展 ...
刘军
core
Research Progress on Nano-Delivered Plant Polyphenols in the Prevention and Treatment of Alzheimer’s Disease [PDF]
Alzheimer’s disease (AD) is one of the most common neurodegenerative diseases with a complex pathological mechanism, and as the incidence of AD has increased recently, there is an urgent need to develop more effective prevention and treatment methods ...
GUO Hui, JIANG Jianrong, LIANG Yanzi, JIANG Mengzhen, ZHANG Lin, ZHOU Jue, ZHONG Hao, LI Yunhong
core +1 more source
Verbascoside Inhibits the Activation of NLRP3 Inflammasome and Improves BV-2 Cell Inflammatory Damage [PDF]
Objective: To investigate the main component verbascoside (VB) in Osmanthus fragrans which inhibits NLRP3 inflammasome activation to improve inflammatory damage in BV-2 cells and its related mechanisms.
Fang CHENG +7 more
core +1 more source
HUVECs Promote the Proliferation of iPS-MSCs by FAM3B [PDF]
, 2016 间充质干细胞（mesenchymalstemcells，MSCs）存在于一个血管周微环境中，在这个微环境内，内皮细胞（endothelialcells，ECs）与MSCs互相作用，调控MSCs的表型和增殖，从而在MSCs的血管生成作用和治疗应用方面起重要作用。然而，MSCs受到来源、年龄、健康等多方面的影响，不能满足大规模的使用需求。诱导多能干细胞来源的间充质干细胞（inducedpluripotentstemcell-derivedMSCs，iPS-MSCs）可能会是一个有前景的替代性干细胞来源。但是，
冷云
core
[High homocysteine level promotes autophagy and apoptosis of mouse hippocampal HT22 cells through the Notch1/Hes1 signaling pathway]. [PDF]
Nan Fang Yi Ke Da Xue Xue Bao, 2023 Zhang J +5 more
europepmc +1 more source
葡萄糖限制对丙烯醛诱导的永生化小鼠海马神经元神经毒性的保护作用
Zhongshan Daxue xuebao. Yixue kexue ban目的探讨葡萄糖限制（GR）对丙烯醛诱导的神经毒性及AD病理的影响。方法永生化小鼠海马神经元HT22细胞预先用不同浓度葡萄糖（25 mmol/L、17.5 mmol/L、12.5 mmol/L）的培养基处理，随后用丙烯醛（25 μmol/L）孵育指定时间后，采用MTT法和流式细胞术分别检测细胞活力和凋亡情况，并通过酶联免疫吸附试验（ELISA）试剂盒检测谷胱甘肽（GSH）、超氧化物歧化酶（SOD）和丙二醛（MDA）的变化。Western blot检测神经营养因子BDNF ...
张丽, 汪园园, 张汀滢, 黄颖娟
doaj
[Lead exposure aggravates Aβ1-42-induced microglial activation and copper ion accumulation in microglial cells]. [PDF]
Nan Fang Yi Ke Da Xue Xue Bao, 2023 Chen L, Huang D, Zheng G, Meng X.
europepmc +1 more source
[Effect of astragaloside IV on the expression of NOD-like receptor protein 3 inflammasome in neonatal rats with hypoxic-ischemic brain damage]. [PDF]
Zhongguo Dang Dai Er Ke Za Zhi, 2021 Li N +5 more
europepmc +1 more source
[Research advances in the role of ferroptosis in neonatal hypoxic-ischemic brain damage]. [PDF]
Zhongguo Dang Dai Er Ke Za Zhi, 2021 Zhu KY, Hei MY.
europepmc +1 more source
[Formononetin downregulates P53/SAT1/ACSL4 pathway-mediated ferroptosis to improve hypoxic-ischemic brain injury in neonatal mice]. [PDF]
Nan Fang Yi Ke Da Xue Xue BaoGuo T +8 more
europepmc +1 more source