Results 101 to 110 of about 25,741 (229)

Neurophysiological evidence for goal‐directed attentional control dysfunction in generalized anxiety disorder

Journal of Intelligent Medicine, Volume 3, Issue 3, Page 312-326, September 2026.
Abstract Attentional control theory posits that anxiety disrupts goal‐directed attentional system; however, its neurophysiological mechanisms in generalized anxiety disorder (GAD) remain unclear. This study investigated two core operations of the goal‐directed attentional system in GAD—inhibition and shifting—by characterizing their behavioral and ...
Xinyu Hao, Xiaoya Liu, Danfeng Yuan, Chunyu Liang, Xiangyun Yang, Bo Zhang, Zhanjiang Li, Shuang Liu   +7 more
wiley   +1 more source

Facile, high‐throughput protein purification enabled by high‐efficiency protease elution

Protein Science, Volume 35, Issue 9, September 2026.
Abstract While advances in artificial intelligence have made protein design widely accessible, protein production and characterization remain a bottleneck. Protease‐cleavable affinity tags are commonly used to improve yield and purity of recombinant proteins, but tag removal adds labor and complexity.
Edson N. Cárcamo Noriega, Ian S. Truebridge, Frank D. Teets III, James W. Bowman III, Nathalia Rodriguez, Tessa A. Howard, Christopher D. Bahl   +6 more
wiley   +1 more source

Cardiovascular‐Kidney‐Metabolic Syndrome: Conceptualising an Approach to Health Economic Modelling

Diabetes, Obesity and Metabolism, Volume 28, Issue 9, Page 7802-7813, September 2026.
ABSTRACT Aims Cardiovascular‐kidney‐metabolic (CKM) syndrome has developed into a global public health crisis. Although integrated care is increasingly used to treat patients with CKM, current health economic models fail to capture the value of considering the CKM syndrome as a unified condition.
Volker Foos, Jieling Chen, Phil McEwan, Marc Evans, Pardeep S. Jhund, Paul R. Kalra, Hongtu Zhu, David C. Wheeler, Geraint Roberts, Martin R. Cowie, Andrew H. Briggs   +10 more
wiley   +1 more source

Redefining Regulatory Proof: The End of the Two‐Trial Paradigm

Fundamental &Clinical Pharmacology, Volume 40, Issue 5, September 2026.
ABSTRACT The recent decision to establish a single pivotal trial as the default evidentiary standard for Food and Drug Administration (FDA) approval marks a substantive shift in the architecture of regulatory proof. This marks a shift from replication‐based validation to a coherence‐based model of sufficiency, beyond a procedural adjustment.
Jean‐Christophe Lega, Steeve Provencher, Bruno Falissard, Clara Locher, Matthieu Roustit, Arthur Gougeon, Rémy Boussageon, Sylvie Chevret   +7 more
wiley   +1 more source

Quasi‐Standard Platform of AlScN Piezoelectric Integrated MEMS Technology (PIMT) For Multi‐Project Wafer Fabrication

Advanced Sensor Research, Volume 5, Issue 8, August 2026.
This report presents an 8‐inch quasi‐standard piezoelectric integrated MEMS technology (PIMT) platform which, through the integration of core and additional processes, reliably supports three rounds of multi‐project wafer (MPW) fabrication. Whilst ensuring support for mass production processes, the platform offers certain flexibility, providing a ...
Yongquan Su, Yuqiang Hu, Xingwang Zhu, Wenli Xue, Hao Huang, Yichen Liu, Jiachen Han, Anna Li, Cheng Zhang, Wanzhu Qiao, Jiaqi Huang, Peng Ding, Qianying Sun, Huan Liu, Tao Wu, Lihao Wang, Yang Wang, Hao Chen, Zhenyu Wu   +18 more
wiley   +1 more source

All‐Flex Plasma Patch for In Vivo Delivery of Reactive Species

Advanced Science, Volume 13, Issue 45, 13 August 2026.
A fully flexible plasma patch enables stable, conformal treatment on complex biological surfaces and enhances transdermal delivery of reactive species. This platform achieves significant tumor suppression in vivo and reveals coordinated regulation of calcium signaling, metabolism, and programmed cell death, providing a promising strategy for safe and ...
Luxiang Zhao, Abulaihaiti Tuergong, Hanshu Yang, Shuang Xue, An Yan, Mingzhen Wang, Weilong Song, Wenzhe Si, Ruixue Wang   +8 more
wiley   +1 more source

Beyond the grave: Do the dead have rights?

Anatomical Sciences Education, Volume 19, Issue 8, Page 1360-1366, August 2026.
Abstract Anatomists who work with the Dead often see themselves as custodians of the Dead. To those who opine that the Dead no longer have Rights (legal or moral) or privileges and have nothing more to contribute to the development of Society or to human endeavor, the Dead's custodians might respond that there is ample evidence that some Rights and ...
Beverley Kramer, Bernard Moxham
wiley   +1 more source

Advanced therapy medicinal products (ATMPs) – An analysis of the global regulatory status

British Journal of Clinical Pharmacology, Volume 92, Issue 8, Page 2909-2916, August 2026.
Abstract Background A rapid progress in the development of advanced therapy medicinal products (ATMPs) has taken place over the past decades. The ATMPs hold great potential but face challenges in the clinical development and the regulatory process.
Allan Cramer, Freja Karuna Hemmingsen Sørup, Marie Lund, Tonny Studsgaard Petersen, Kristian Karstoft   +4 more
wiley   +1 more source

Colorectal Cancer in Bhutan: Identifying Health System Gaps and Priorities

Cancer Medicine, Volume 15, Issue 8, August 2026.
ABSTRACT Background Colorectal cancer (CRC) is an emerging public health concern in Bhutan, a lower‐middle‐income country with a geographically challenging terrain and limited specialised oncology services. As the country undergoes an epidemiological and economic transition, CRC numbers are steadily increasing.
Chuan De Foo, Sonam Yoezer, Tashi Dendup Wangdi, Prabhat Pradhan, Yun Le Linn, Chong Tsung Wen, Elliot Eu, Vanessa Yik, Jia Lin Ng, Jeremy Tian Hui Tan, Fung Joon Foo, Evelyn Wong, Taufique Joarder   +12 more
wiley   +1 more source

Influence of Thickness in the Color Masking Ability of Different Types of Computer‐Aided Design and Manufacturing Ceramics

Clinical and Experimental Dental Research, Volume 12, Issue 4, August 2026.
ABSTRACT Objectives Tooth discoloration is a major esthetic concern in cosmetic dentistry. This study investigated the color‐masking ability of four CAD/CAM ceramics and the influence of material type and thickness on their optical properties. Materials and Methods A total of 120 A1‐shade CAD/CAM ceramic specimens were prepared from Vitablocs Mark II ...
Seyede Mohaddeseh Hosseini Kalej, Behnaz Esmaeili, Ghazaleh Ahmadi Zenouz, Hemmat Gholinia   +3 more
wiley   +1 more source