Influence of Storage Temperature on Radiochemical Purity of 99mTc-Radiopharmaceuticals [PDF]
Molecules, 2018 The influence of effective room temperature on the radiochemical purity of 99mTc-radiopharmaceuticals was reported. This study was born from the observation that in the isolators used for the preparation of the 99mTc-radiopharmaceuticals the temperatures
Licia Uccelli +2 more
exaly +7 more sources
Evaluation of Tetrofosmin Cold Kit Fractionation Using Alternative New Method of Quality Control for Testing Radiochemical Purity [PDF]
World Journal of Nuclear Medicine, 2022 Objective The aim of this study is to establish a method for the fractionation of tetrofosmin cold kit under different storage conditions and to optimize an alternate chromatography method from the reference method to test radiochemical purity (RCP).
Nisha Bhatia +4 more
doaj +2 more sources
Co-57-based intercomparison of TLC scanners and dose calibrators for low-activity radiochemical purity assessment in radiopharmaceutical quality control [PDF]
EJNMMI Radiopharmacy and ChemistryBackground Thin layer chromatography scanners and dose calibrators are commonly used to assess radiochemical purity of radiopharmaceutical preparations. Strict quality assurance programs surveyed by regulatory bodies exist for dose calibrators, but they ...
Marietta Straub +5 more
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Improvement of End-of-Synthesis Radiochemical Purity of 177Lu-DOTA-PSMA-Ligands with Alternative Synthesis Approaches: Conversion Upswing and Side-Products Minimization [PDF]
PharmaceuticsBackground: Radiochemical purity is a key criterion for the quality of radiopharmaceuticals used in clinical practice. The joint improvement of analytical methods capable of identifying related radiochemical impurities and determining the actual ...
Anton Larenkov +2 more
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An alternative methodology for the determination of the radiochemical purity of 11C-methionine [PDF]
EJNMMI Radiopharmacy and Chemistry, 2018 Background [11C]Methionine ([11C]MET) acts as an oncological radiopharmaceutical for measuring increased protein synthesis in brain tumours while having low uptake in normal brain an.
Javier Giglio +5 more
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Multifactorial analysis of radiochemical purity in high-activity 177Lu-labeled theranostics: impact of precursor source, 177Lu form, and production parameters [PDF]
EJNMMI Radiopharmacy and ChemistryBackground Lutetium-177 (177Lu) theranostics have revolutionized personalized cancer treatment, particularly with FDA-approved therapies like [177Lu]Lu-DOTA-TATE for neuroendocrine tumors and [177Lu]Lu-PSMA for prostate cancer.
William Hunt +9 more
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A Review on Radiochemical Purity Analysis Methods of Radiopharmaceuticals
Journal of Isotopes, 2021 Radiopharmaceuticals means radionuclide preparations or labeled compounds for clinical diagnosis or therapeutic use. Radiochemical purity is one of the important judgment indexes to measure the quality of radiopharmaceuticals, which directly affects the ...
ZHANG Yun;YANG Liu;JIANG Hua
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The determination of the radiochemical purity of Actinium-225 radiopharmaceuticals: a conundrum. [PDF]
EJNMMI Radiopharm Chem, 2022 Kleynhans J, Duatti A.
europepmc +4 more sources
Bridging Research and Clinical Practice: Automated [68Ga]Ga-FAPi-46 Synthesis and Quality Control for Oncological PET Imaging [PDF]
PharmaceuticalsBackground/Objectives: Fibroblast activation protein (FAP) has emerged as a promising target for oncologic molecular imaging due to its high expression in cancer-associated fibroblasts and low presence in healthy tissues.
Caiubi Rodrigues de Paula Santos +5 more
doaj +2 more sources
Improved Method for Determination of Chemical and Radiochemical Purity [PDF]
Proceedings, 2019 Radiopharmaceuticals are radioactive compounds that have in their structure a radioisotope attached to drugs, which accumulate in certain organs or tissues. [...]
Maria-Roxana Cornoiu +3 more
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