Results 41 to 50 of about 16,167 (209)

A FAP‐Targeted SMDC Platform Enables Synergistic Radionuclide–Chemotherapy with PET‐Guided Evaluation

Advanced Science, EarlyView.
A fibroblast activation protein (FAP)‐targeted small molecule–drug conjugate (SMDC) platform is developed to integrate PET imaging with synergistic radionuclide–chemotherapy. Linker chemistry governs stability, exposure, and tolerability, with the VC linker providing superior in vivo performance.
Ruitao Yang, Hongxin Li, Zexin Xu, Baocheng Chen, Ningjie Li, Yuhua Zhong, Kongzhen Hu   +6 more
wiley   +1 more source

Rapid isocratic HPLC investigation of radiochemical purity for 90Y-DOTATATE

, 2011
DOTA-conjugated peptides, such as [DOTA(0), Tyr(3)]ocreotide (DOTATOC) and [DOTA(0), Tyr(3)]octreotate (DOTATATE) can be labeled with radionuclides such as Y-90, Lu-177 and In-111 at high specific activities.
Fikret Büyükkaya, Tasdelen, Betul, Ergun, Aysun, Betül Taşdelen, Aysun Ergun, BÜYÜKKAYA, Fikret   +5 more
core   +1 more source

Influence of the Generator in-Growth Time on the Final Radiochemical Purity and Stability of Radiopharmaceuticals [PDF]

, 2013
At Legnaro laboratories of the Italian National Institute for Nuclear Physics (INFN), a feasibility study has started since 2011 related to accelerated-based direct production of by the 100Mo(p,2n) reaction.
M. Giganti, TAIBI, Angelo, A. Taibi, UCCELLI, Licia, DI DOMENICO, Giovanni, M. Pasquali, A. Duatti, DUATTI, Adriano, J. Esposito, PUPILLO, Gaia, PASQUALI, Micol, GAMBACCINI, Mauro, M. Gambaccini, BOSCHI, Alessandra, L. Uccelli, GIGANTI, Melchiore, G. Di Domenico, G. Pupillo, A. Boschi   +18 more
core   +1 more source

Radiochemical effects of thermal neutron capture in Cr(tmhd)₃: method development [PDF]

, 2022
The radiochemical effects of thermal neutron capture in tris(2,2,6,6-tetramethyl-3,5-heptandionato)chromium(III) (Cr(tmhd)₃) were investigated. A method was devised to quantify the amount of the induced ⁵¹Cr activity recoverable in the original chemical ...
Welch, Jan M.; orcid:, Sterba, Johannes H.; orcid:, Pichler, Vanessa; orcid:   +2 more
core   +1 more source

A comparison of radiochemical purity testing of 99m Tc-Pentetate (DTPA) between paper and thin layer chromatographic techniques

Journal of Associated Medical Sciences, 2016
Introduction: 99mTc-Pentetate or 99mTc-DTPA (99mTc-diethylenetriaminepentaacetic acid) is radiopharmaceutical material for renal function study in nuclear medicine.
Montree Tungjai, Thitima Yingyai, Tarika Thumvijit   +2 more
doaj  

Development and Validation of a Radiochemical Purity Determination Method for [68Ga]Ga-DOTA-CXCR4-D1

Journal of Isotopes
CXCR4 is a chemokine receptor widely overexpressed on the surface of various tumor cells. Given its pivotal role in tumor invasion，metastasis，and recurrence，it has emerged as a key target in molecular imaging.
Jingjing YU, Xiaoming WANG, Houquan LI, Xu ZHOU, Hongyu LI, Yang PEI, Xiangyu QIN, Kai WEN, Guobao WANG   +8 more
doaj   +1 more source

Effect of High Activity Technetium-99m on the Stability of Tc-99m Tetrofosmin as Injectable radiopharmaceuticals [PDF]

Journal of Pure and Applied Chemistry Research, 2018
Technetium-99m (Tc-99m) labeled tetrofosmin kit has been widely used in hospitals including in Indonesia. Usually, tetrofosmin kits and Tc-99m pertechnetate are supplied separately, but recently there has been a new trend where Tc-99m tetrofosmin is ...
Widyastuti Widjaksana, Puji Widayati, Yunilda Alwi, Lindawati N   +3 more
doaj   +1 more source

Percent radiochemical purity of [^99mTc]MBT2 and [^99mTc]BT2 as a function of time.

, 2016
Percent radiochemical purity of [99mTc]MBT2 and [99mTc]BT2 as a function of time.
Hiroyuki Watanabe (312793), Masashi Yoshimura (328061), Masafumi Ihara (302200), Masahiro Ono (106488), Shimpei Iikuni (458368), Hatsue Ishibashi-Ueda (781355), Hideo Saji (458369)   +6 more
core   +1 more source

Validation of 5 analytical methods (pH, peptide concentration, loss on drying radiochemical purity, peptide identity and purity) for quality control of the kits used for Ga-68 radiolabeling

, 2023
Kits are gaining popularity as a known convenient labelling procedure for gallium-68 based radiopharmaceuticals in the Nuclear Medicine clinic. Cold kits are a benefit to small radiopharmaceutical sites, but their quality should be checked in the same ...
Biljana Marjanovic-Painter (16844823)
core   +1 more source

Radiochemical purity and stability of 99mTc-HMPAO in routine preparations

, 2017
The aim of this work was to investigate the influence of pH, recovery volume, type of saline solution plastic or glass container, used to prepare the technetium-99m-d,l-hexamethylpropyleneamineoxime ([Tc-99m]Tc-d,l-HMPAO] radiopharmaceutical starting ...
Alessandra Boschi, PASQUALI, Micol, UCCELLI, Licia, Micol Pasquali, BOSCHI, Alessandra, Petra Martini, Licia Uccelli, MARTINI, Petra   +7 more
core   +1 more source