Results 61 to 70 of about 16,167 (209)

Development of a Novel 18F‐Labeled Radioligand for Imaging Translocator Protein With Positron Emission Tomography

iRADIOLOGY, EarlyView.
Translocator protein 18 kDa (TSPO) is a well‐established biomarker of neuroinflammation and is implicated in the pathophysiology of various neurodegenerative diseases. This study presents [18F]TSPO‐1118 ([18F]3) as a promising positron emission tomography (PET) radioligand for imaging TSPO with high affinity, robust brain uptake, and specificity in ...
Jian Rong, Chunyu Zhao, Xin Zhou, Jiahui Chen, Yabiao Gao, Zhendong Song, Yinlong Li, Zijing Li, Steven H. Liang   +8 more
wiley   +1 more source

Bioinorganic Site‐Specific Conjugation of Multi‐Arm Linkers to Create Pharmaceuticals With Targeting and Effector Functions

Journal of the Chinese Chemical Society, EarlyView.
This Account showcases a modular, multi‐arm linker platform that decouples payload loading from antibody conjugation. By leveraging a computationally designed ACPGHA zinc‐binding motif, we demonstrate the construction of homogeneous antibody‐drug conjugates and theranostic antibody‐radionuclide conjugates with high payload loading. The multi‐arm linker
Cédric Grauffel, Tse Wen Chang, Carmay Lim   +2 more
wiley   +1 more source

Quantification of 10B and 11B in Biological Samples in Translational Science and Clinical Applications for Boron Neutron Capture Therapy (BNCT)

Medicinal Research Reviews, EarlyView.
ABSTRACT Boron neutron capture therapy (BNCT) is a targeted radiotherapy that exploits the selective accumulation of the 10B isotope within tumors, followed by irradiation with low‐energy neutrons to induce high linear energy transfer particles with short path lengths, resulting in localized tumor cell destruction while sparing surrounding healthy ...
Christoph Selg, Wolfgang A. G. Sauerwein, Evamarie Hey‐Hawkins   +2 more
wiley   +1 more source

TECHNETIUM 99m RADIOPHARMACEUTICAL RADIOCHEMICAL PURITY TESTING: A COMPARISON BETWEEN STANDARD RADIOCHROMATOGRAPH METHOD AND A ALTERNATIVE EMERGENCY PROCEDURE [PDF]

, 2022
openLo scopo della tesi è quello di identificare una valida metodica alternativa, rispetto a quelle presenti in normativa, che permette di determinare la purezza radiochimica dei radiofarmaci tecneziati.
BABOLIN, MATTEO
core  

Longitudinal Tracking of Astrocyte Reactivity During the Development of Chronic Orofacial Neuropathic Pain Using [18F]‐SMBT‐1 Positron‐Emission Tomography

Glia, Volume 74, Issue 8, August 2026.
Using [18F]‐SMBT‐1 PET, we longitudinally tracked MAO‐B–expressing reactive astrocytes during orofacial neuropathic pain development in rats, revealing region‐ and time‐specific astrocyte activation during pain chronification. ABSTRACT Chronic neuropathic pain represents a significant global health burden and is hypothesized to be maintained by an ...
Lewis S. Crawford, James W. M. Kang, OIivia I. Davanzo, Hyunsol Lim, Sabrina Salberg, Marissa Srgo, Crystal Li, Gaelle M. Emvalomenos, Bianca Jupp, Matthew Long, Wayne Noonan, Mohammad B. Haskali, Richelle Mychasiuk, Kevin A. Keay, Luke A. Henderson   +14 more
wiley   +1 more source

Forcing the Side‐on π‐Coordination of a C≡C Triple Bond to Technetium Using the As,CC,As Alkyne Pincer Ligand 1,2‐Bis(2‐(diisopropylarsaneyl)‐4‐(trifluoromethyl)phenyl)Ethyne

Angewandte Chemie International Edition, Volume 65, Issue 25, 15 June 2026.
Technetium alkyne complexes have eluded isolation for decades with the only indicators for their existence being the isolation of vinylidene carbenes or their follow‐up reaction products despite plentiful of reports for neighboring elements. Stable, crystalline Tc(III) and Tc(V) alkyne complexes (and their Re analogs) have now been prepared and fully ...
Maximilian Roca Jungfer, Moritz Johannes Ernst, Lukas Eberle, Marius Kesselring, Guilhem Claude, Joachim Ballmann   +5 more
wiley   +1 more source

The Reevaluation of MIBI as the Ligand of 99mTc-MIBI Radiopharmaceutical for Myocardial Imaging

Atom Indonesia, 2008
Methoxy isobutyl isonitrile labelled with technetium-99m (99mTc) radionuclide can be used for the evaluation of acute myocardial infarction. The 99mTc-MIBI radiopharmaceutical is available in the lyophilized-kit, which is separately packed with its ...
Z. Nurlaila, I. Daruwati
doaj   +1 more source

Establishment of Thin Layer Chromatographic Method for Determination of Radiochemical Purity of Technetium[99mTc] Methylenediphosphonate Injection

Journal of Isotopes, 2023
To establish a reliable method for measuring the radiochemical purity of technetium[99mTc] methylenediphosphonate injection, analysis conditions such as stationary phase and developing solvent were studied.
WANG Yong, LIANG Su, CUI Xiaoyan, JIANG Hua, ZHANG Yun, YANG Liu
doaj  

Synthesis of an Al18F radiofluorinated GLU-UREA-LYS(AHX)-HBED-CC PSMA ligand in an automated synthesis platform

EJNMMI Radiopharmacy and Chemistry, 2018
Background Overexpression of prostatic membrane antigen (PSMA) is associated with the progression and prognosis of prostate cancer. There are numerous studies using this peptide with the 68Ga radionuclide.
Javier Giglio, Maia Zeni, Eduardo Savio, Henry Engler   +3 more
doaj   +1 more source

Tracking of [14C]Polystyrene Nanoplastics in Pregnant Mice

Advanced Science, Volume 13, Issue 32, 9 June 2026.
This study investigates [14C]polystyrene nanoplastic ([14C]PS) translocation in late‐stage pregnant mice after intranasal (0.5 mg of [14C]PS on GD12, GD14, and GD16, n = 6) and intravenous administration (1.5 mg of [14C]PS on GD16, n = 6). 14C‐radiolabel allows quantitative tracking of unmodified polystyrene nanoplastics.
Olga Khaybullina, Pallavi Sarkhel, Outi M. Keinänen   +2 more
wiley   +1 more source