Results 41 to 50 of about 25,741 (229)
Early‐stage health technology assessment of a curative gene therapy for multiple sclerosis
British Journal of Clinical Pharmacology, EarlyView.Aims Multiple sclerosis (MS) is associated with significant early morbidity, reduced life expectancy and substantial healthcare and societal costs. The primary objective of this study is to assess the early cost‐effectiveness potential of a novel gene therapy, IMMUTOL, for MS compared with current high‐efficacy treatment sequences.
Attila Imre, Balázs Nagy, Rok Hren
wiley +1 more source
Journal of Interventional Epidemiology and Public HealthIntroduction: L’approche World Health Organization Package of Essential Nonconmmunicable (WHOPEN)permet la prévention, la détection précoce et la prise en charge de l’hypertension artérielle (HTA) et diabète.
Bassotom Lakougnon +9 more
doaj +1 more source
Journal of Pharmaceutical Policy and Practice, 2021 Background Advanced therapy medicinal products (ATMPs) represent an important cornerstone for innovation in healthcare. However, uncertainty on the value, the high average cost per patient and their one-shot nature has raised a debate on their assessment
Virginia Ronco +4 more
doaj +1 more source
British Journal of Clinical Pharmacology, EarlyView.Patient‐reported outcomes (PROs) are essential for assessing clinical benefit and tolerability from the patient's perspective. In oncology trials, PRO data analysis often involves responder and time‐to‐event analyses, which depend on predefined thresholds to determine clinically meaningful change.
Anna Margarete Maria Thurner +5 more
wiley +1 more source
Perspectives to mitigate payer uncertainty in health technology assessment of novel oncology drugs
Journal of Market Access & Health Policy, 2019 Reimbursement decisions on new oncology drugs are now often made while uncertainty remains about a drug's risk–benefit profile. One consequence of this is a delay in patient access to valuable new medicines.
Oriol Solà-Morales +2 more
doaj +1 more source
Jurnal Sarjana Teknik Informatika, 2020 Usability adalah seberapa mudah atau ukuran pengguna dalam menggunakan sistem. Pada saat ini Dinas Kearsipan dan Perpustakaan Provinsi Jawa Tengah (Dinas ARPUS) belum ada sistem pencarian lokasi buku (SILOKU).
Nafia Arlila Harsani +1 more
doaj +1 more source
How the HTAR will contribute to a value‐based decision‐making for medicinal products across the EU
British Journal of Clinical Pharmacology, EarlyView.The European Union Health Technology Regulation 2021/2282 (HTAR) introduces joint assessment of health technologies (including medicinal products and medical devices) across EU Member States. It was signed into law in 2021 and came into full force in January 2025.
Roisin Adams, Michal Stanak
wiley +1 more source
Efficacy, safety and cost‐effectiveness of CAR‐T therapy
British Journal of Clinical Pharmacology, EarlyView.CAR T‐cells demonstrate high efficacy in blood cancers, including ALL, MM and DLBCL. Innovations target solid tumours despite challenges such as antigen escape. Combination therapies enhance the delivery and infiltration of CAR T cells. Toxicity, cost and resistance remain major barriers to clinical use.
Emina Karahmet Sher +7 more
wiley +1 more source
Current Development in the Cyclotron Production of 68Ga for Medical Application
Journal of IsotopesAs a positron-emitting radionuclide，68Ga labeled radiopharmaceuticals are widely used in positron emission tomography (PET) imaging to diagnose tumor-related diseases. Currently，68Ga is primarily supplied by 68Ge/68Ga generator.
Ziyu ZHAO +7 more
doaj +1 more source