Results 61 to 70 of about 25,741 (229)
Clinical Pharmacology &Therapeutics, EarlyView.Precision medicine offers the opportunity to improve the benefit–risk profile of new therapies by prospectively identifying patients most likely to respond or least likely to experience harm; however, its systematic integration into drug development remains inconsistent outside oncology.
Ingrid Holst‐Laubjerg +1 more
wiley +1 more source
European Policy Analysis, EarlyView.ABSTRACT Policy process research has excelled in explaining structural policy change within national settings, but extensions and applications to the EU level have long proven challenging for scholars. Given that the EU is currently experiencing its longest period of Treaty stability since the 1980s—having evolved into a sui generis political system ...
Vassilis Karokis‐Mavrikos
wiley +1 more source
Journal of Comparative Effectiveness Research, 2022 In this latest update we discuss the transportability of comparative effectiveness evidence across countries. We highlight results of a survey indicating that European HTA agencies are reluctant to accept real-world data from other countries, review ...
Alex Simpson, Sreeram V Ramagopalan
doaj +1 more source
The Efficiency of the German Healthcare System: Some Puzzling Findings
The International Journal of Health Planning and Management, EarlyView.ABSTRACT This article examines the cost‐effectiveness of the German healthcare system from the perspective of statutory health insurance (SHI). Using data for 2011–2014—the most recent period for which consistent national inputs are available—we compare a marginal, system‐wide cost‐effectiveness ratio with the cost‐effectiveness of newly approved ...
Afschin Gandjour
wiley +1 more source
Knee Surgery, Sports Traumatology, Arthroscopy, EarlyView.Abstract Purpose To compare three posterolateral corner (PLC) reconstruction techniques—the popliteofibular loop (PFLoop), the modified LaPrade (LP) and modified Arciero (AR) techniques—in restoring knee laxity in varus (VR), external tibial rotation (ER) and posterior tibial translation (PTT). Methods Nine cadaveric knees were subjected to 8Nm VR, 5Nm
Marcos Barbieri Mestriner +5 more
wiley +1 more source
Knee Surgery, Sports Traumatology, Arthroscopy, EarlyView.Abstract Purpose The objective was to measure effects of joint line obliquity (JLO) on meniscus posterior root tension, tibiofemoral subluxation and contact pressures. It was hypothesised that a medial JLO would increase medial meniscal (MM) root tension, medial tibiofemoral subluxation and medial compartment contact pressure, and vice versa for ...
Shuntaro Nejima +5 more
wiley +1 more source
Knee Surgery, Sports Traumatology, Arthroscopy, EarlyView.Abstract Purpose This study aimed to compare strength recovery, functional and clinical outcomes between full‐ and partial‐thickness quadriceps tendon autografts for 12 months post‐operatively and to examine the clinical implications of graft thickness in anterior cruciate ligament reconstruction among non‐professional competitive soccer players ...
Jose Luis Martin‐Alguacil +6 more
wiley +1 more source
This document addresses steps undertaken in the can.heal pilots to harmonize multi-center recruitment and delocalized testing, material and data exchange, to implement a strategy for role-dependent inclusion of the participating centers, as well as data collection and sharing.
Giacomini, Patrizio, Trapani, Valentina
openaire +3 more sources
Mass Spectrometry Reviews, EarlyView.ABSTRACT Top‐down proteomics (TDP) characterizes proteoforms in cells, tissues, and biofluids, in discovery mode and on a global scale, requiring analytical tools with high peak capacity for proteoform separation and high sensitivity for proteoform detection, given the extremely high proteoform complexity and wide proteoform concentration dynamic range.
Guijie Zhu +5 more
wiley +1 more source