Results 121 to 130 of about 24,253,245 (291)
PLoS ONE, 2017 Background Salvador is the city with the highest number of HTLV-1 infected individuals in Brazil, yet the main route of HTLV-1 transmission is unknown. Objective To investigate the association of syphilis infection as a proxy for sexual transmission of ...
David Nunes +7 more
semanticscholar +1 more source
The HTLV-1 Virological Synapse [PDF]
Viruses, 2010 Human T-lymphotropic virus-1 (HTLV-1) spreads efficiently between T-cells via a tight and highly organized cell-cell contact known as the virological synapse. It is now thought that many retroviruses and other viruses spread via a virological synapse, which may be defined as a virus-induced, specialized area of cell-to-cell contact that promotes the ...
Mohamed Nejmeddine, Charles R.M. Bangham
openaire +3 more sources
B‐cell depletion limits HTLV‐1‐infected T‐cell expansion and ameliorate HTLV‐1‐associated myelopathy
Annals of Clinical and Translational NeurologyObjective Human T‐cell leukemia virus type 1‐associated myelopathy (HAM) is a chronic, progressive, inflammatory disease with unclear pathogenesis and no effective treatments. We aimed to investigate a novel mechanistic theory and treat HAM patients with
Aowei Lv +9 more
doaj +1 more source
Revista do Instituto de Medicina Tropical de São Paulo, 2009 Epidemiological studies conducted in Peru disclosed HTLV-1 to be prevalent in different ethnic groups, and found HTLV-2 in some Amazonian Indians and in men who have sex with men.
Nadia Carmela Santos Quispe +3 more
doaj +1 more source
From Genomic and Epigenomic Maps to Medicines in Adult T‐Cell Leukemia/Lymphoma
Cancer Science, Volume 117, Issue 2, Page 289-296, February 2026.ABSTRACT Adult T‐cell leukemia/lymphoma (ATL) is an aggressive and refractory hematologic malignancy that is caused by human T‐cell leukemia virus type‐1 (HTLV‐1) retrovirus. ATL results from a combination of viral latency and the accumulation of abnormalities throughout the genome, epigenome, transcriptome, and signaling pathways.
Kako Suzuki, Makoto Yamagishi
wiley +1 more source
Modeling HTLV-1 and HTLV-2 co-infection dynamics
AIMS MathematicsWith the increasing prevalence of viral infections, the human T-cell leukemia virus (HTLV) is becoming a focal point of research. Of the four identified strains, HTLV-1 and HTLV-2 are particularly associated with various health issues.
E. A. Almohaimeed +2 more
doaj +1 more source
Role of HTLV-1 Tax and HBZ in the Pathogenesis of HAM/TSP
Frontiers in Microbiology, 2017 Human T cell lymphotropic virus type 1 (HTLV-1) infection can lead to development of adult T cell leukemia/lymphoma (ATL) or HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP) in a subset of infected subjects.
Yoshimi Enose-Akahata +2 more
semanticscholar +1 more source
Integration Site and Clonal Expansion in Human Chronic Retroviral Infection and Gene Therapy [PDF]
, 2014 Retroviral vectors have been successfully used therapeutically to restore expression of genes in a range of single-gene diseases, including several primary immunodeficiency disorders.
Bangham, CRM, Niederer, HA
core +2 more sources
Immunovirological markers in HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Retrovirology, 2019 Human T cell lymphotropic virus 1 (HTLV-1) is a human retrovirus and infects approximately 10–20 million people worldwide. While the majority of infected people are asymptomatic carriers of HTLV-1, only 4% of infected people develop HTLV-1-associated ...
Yoshimi Enose-Akahata, S. Jacobson
semanticscholar +1 more source
The Exceptional Oncogenicity of HTLV-1
Frontiers in Microbiology, 2017 Human T-cell leukemia virus-1 (HTLV-1) is the first pathogenic human retrovirus identified in 1979 by the Gallo group. HTLV-1 causes fatal T-cell leukemia (adult T cell leukemia) and a progressive myelopahy (HTLV-1-associated myelopathy/ tropical spastic
Y. Tagaya, R. Gallo
semanticscholar +1 more source