Results 111 to 120 of about 29,732,513 (224)

HTLV-1 HBZ Viral Protein: A Key Player in HTLV-1 Mediated Diseases [PDF]

, 2017
Human T cell leukemia virus type 1 (HTLV-1) is an oncogenic human retrovirus that has infected 10–15 million people worldwide. After a long latency, 3–5% of infected individuals will develop either a severe malignancy of CD4+ T cells, known as Adult T ...
Baratella, Marco, Forlani, Greta, Roberto S. Accolla, Accolla, Roberto, Marco Baratella, Greta Forlani   +5 more
core   +1 more source

HTLV-1 infected cells robustly trigger IFN-I response by pDCs in a TLR7- and cell-cell contact dependent manner.

, 2019
A. Representative FACS analysis of pDC isolation and depletion from PBMCs using the CD123 and BDCA-2 pDC selective markers. B. Representative quantification of IFN-I activity in the supernatants of PBMCs, isolated pDCs and pDC-depleted PBMCs (responders)
Sonia Assil (650210), Antoine Gessain (31917), Renaud Mahieux (149806), François-Loïc Cosset (51395), Sandrine Alais (334301), Nicolas Futsch (3938258), Marlène Dreux (267031), Hélène Dutartre (119499), Elodie Décembre (5661202)   +8 more
core   +1 more source

Untangling the causes of geographical disparities in the clinical outcome of HTLV-1 infection: a critical perspective on the contribution of viral genetic diversity

Journal of Virology
Human T-cell leukemia/lymphoma virus type 1 (HTLV-1) is the etiological agent of two major diseases, adult T-cell leukemia/lymphoma (ATLL) and HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP), as well as various other inflammatory ...
Thomas Duchateau, Philippe V. Afonso, Chloé Journo   +2 more
doaj   +1 more source

Kinetics of HTLV-1 reactivation from latency quantified by single-molecule RNA FISH and stochastic modelling.

PLoS Pathogens, 2019
The human T cell leukemia virus HTLV-1 establishes a persistent infection in vivo in which the viral sense-strand transcription is usually silent at a given time in each cell.
Michi Miura, Supravat Dey, Saumya Ramanayake, Abhyudai Singh, David S Rueda, Charles R M Bangham   +5 more
doaj   +1 more source

Interactions of HTLV Tax oncoproteins with the p65/RelA factor of the NF-kB pathway.

, 2008
Interactions of HTLV Tax oncoproteins with the p65/RelA factor of the NF-kB ...
LORENZI, Pamela, BERTAZZONI, Umberto, Avesani F., TURCI, Marco, ROMANELLI, Maria, BIDOIA, Carlo   +5 more
core   +1 more source

Disulfide-mediated apoptosis of human T-lymphotrophc virus type-I (HTLV-I)-infected cells in patients with HTLV-I-associated myelopathy/tropical spastic paraparesis. [PDF]

, 2009
BACKGROUND: This study was conducted to construct a basis for a therapeutic strategy against human T-lymphotropic virus type-I (HTLV-I)-associated myelopathy/tropical spastic paraparesis (HAM/TSP) using a compound that contained a disulfide moiety ...
Eguchi, Katsumi, Nakamura, Hideki, Fukushima, Naomi, Ida, Hiroaki, Nishiura, Yoshihiro, Nakamura, Tatsufumi, Aramaki, Toshiyuki   +6 more
core  

HTLV-1 Tax mutants that do not induce Garrest are disabled in activating the anaphase promoting complex-4

, 2011
Copyright information:Taken from "HTLV-1 Tax mutants that do not induce Garrest are disabled in activating the anaphase promoting complex"http://www.retrovirology.com/content/4/1/35Retrovirology 2007;4():35-35.Published online 29 May 2007PMCID:PMC1894815.
Randall Merling (75706), Chou-Zen Giam (75711), Sohee Hong (75708), Meihong Liu (75709), Yu-Liang Kuo (75710), Ling Zhang (18071), Chunhua Chen (75707)   +6 more
core   +1 more source

HTLV-1 CTCF-binding site is dispensable for in vitro immortalization and persistent infection in vivo

Retrovirology, 2019
Background Human T-cell leukemia virus type 1 (HTLV-1) is the etiologic agent of adult T-cell leukemia/lymphoma (ATL) and the neurological disorder HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP).
Michael P. Martinez, Xiaogang Cheng, Ancy Joseph, Jacob Al-Saleem, Amanda R. Panfil, Marilly Palettas, Wessel P. Dirksen, Lee Ratner, Patrick L. Green   +8 more
doaj   +1 more source

HTLV-1-associated myelopathy

Uirusu, 2019
Human T-cell leukemia virus type 1 (HTLV-1) is a retrovirus that infects T lymphocytes. HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP) is an intractable neurodegenerative disease caused by HTLV-1 infection just like adult T cell leukemia/lymphoma (ATL) is, developing in a fraction of infected individuals. Here, we review the update
openaire   +3 more sources

Mimicry between HTLV-I and myelinbasicprotein: No response in HTLV-I-associatedmyelopathypatients

, 1992
The reactivity to a peptide from the HTLV-I polyprotein (FKLPGLNSR) and a similar sequence from myelinbasicprotein (MBP) (FKLGGRDSR) was examined in relation to the proposal that mimicry of MBP by HTLV-I could be involved in autoimmune responses in HTLV ...
Carnegie, P.R., Yashiki, S., Davies, J.M., Davies, J. M., Sonoda, S., Osame, M., Carnegie, P. R.   +6 more
core   +1 more source