Results 41 to 50 of about 21,757,128 (220)

Functional Loss of the HTLV-I Tax Protein Encoded by Variant Proviruses in Infected Individuals. [PDF]

, 1998
Accumulating evidence has indicated the presence of HTLV-I quasispecies in infected individuals. To elucidate their biological consequences, we amplified the whole Tax open reading frame (ORF) of HTLV-I proviruses by nested PCR from six infected ...
Yamashita-Futsuki, Izumi, Roy, Bhabeshchandra, Katamine, Shigeru, Mizokami, Akinari, Moriuchi, Ryozo   +4 more
core  

High-level Expression and One-step Purification of Chimeric Antigen Containing HTLV-I-II Diagnostic Epitopes in Escherichia coli

Iranian Journal of Allergy, Asthma and Immunology, 2020
Purification and preparation of three diagnostic antigens used for the detection of human T-lymphotropic virus (HTLV)-I/-II infection in E.coli are different parts of a multi-step method.
Mahnaz Bezhgi, Mohammad Fazilati
doaj   +1 more source

Ovarian hormone loss modifies the nucleic acid cargo of circulating extracellular vesicles and skeletal muscle metabolism after acute exercise in rats

Experimental Physiology, Volume 111, Issue 10, Page 4578-4619, 1 October 2026.
Abstract Loss of ovarian hormones (i.e., menopause) leads to negative effects on metabolic health. While exercise offers significant benefits, it seems to be insufficient to completely reverse these changes. The mechanisms by which exercise conveys the effects throughout the body are still poorly understood.
Veera Puumalainen, Anni Maja, Tia‐Marje Korhonen, Tuuli A. Nissinen, Eero Hulkko, Janne A. Ihalainen, Maarit Lehti, Sira Karvinen   +7 more
wiley   +1 more source

HTLV-I production based on activation of integrin/ligand signaling in HTLV-I-infected T cell lines derived from HAM/TSP patients. [PDF]

, 2008
OBJECTIVE: Activity of integrin/ligand signaling leading to activation of small GTPases might regulate the efficiency of cell-to-cell spread of human T lymphotropic virus type I (HTLV-I) through the virological synapse. We compared both activity of small
Eguchi, Katsumi, Fukushima, Naomi, Ida, Hiroaki, Nishiura, Yoshihiro, Nakamura, Tatsufumi, Aramaki, Toshiyuki   +5 more
core   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, Volume 20, Issue 9, Page 2296-2322, September 2026.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

Functional interactions of the Tax and p13 proteins of Human T-cell Leukemia Virus Type I [PDF]

, 2013
Human T-cell leukemia virus type 1 (HTLV-1) establishes a lifelong persistent infection in humans. Approximately 3% of the infected individuals will develop adult T-cell leukemia/lymphoma (ATLL), an aggressive malignancy of mature CD4+ T-cells. The viral
Manicone, Mariangela
core  

Seroprevalencia de la infección por HTLV-1 en diferentes grupos de riesgo estudiados en Cuba

Revista Cubana de Medicina, 1998
Se estudiaron, en el período comprendido desde 1991 hasta 1996, 26 352 muestras de suero procedentes de diferentes grupos de riesgo y donantes de sangre para conocer la seroprevalencia de anticuerpos contra el virus linfotrópico de las células T humanas ...
Ana Luisa Lubián Caballero, Héctor Manuel Díaz Torres, Eladio Silva Cabrera, María Teresa Pérez Guevara, Otto Cruz Sui, José Luis de la Fuente Arzola, Leonor Navea Leyva, Enrique Noa Romero   +7 more
doaj  

Performances of HTLV serological tests in diagnosing HTLV infection in high-risk population of São Paulo, Brazil Desempenho de testes sorológicos para o diagnóstico de infecção por HTLV em população de alto-risco de São Paulo, Brasil

Revista do Instituto de Medicina Tropical de São Paulo, 2007
Testing problems in diagnosing human T-lymphotropic virus (HTLV) infection, mostly HTLV-II, have been documented in HIV/AIDS patients. Since December 1998, the Immunology Department of Instituto Adolfo Lutz (IAL) offers HTLV-I/II serology to Public ...
Fabrício Jacob, Elizabeth de los Santos-Fortuna, Raymundo Soares Azevedo, Adele Caterino-de-Araujo   +3 more
doaj   +1 more source

The suppressor of cytokine signaling 3 regulates glioma stem cell maintenance and immune microenvironment through signal transducer and activator of transcription 3 signaling

Journal of Cell Communication and Signaling, Volume 20, Issue 3, September 2026.
We found that SOCS3 deficiency activates STAT3 to enhance glioma stem cell (GSC) stemness and survival. We demonstrated that IL‐6 rescues STAT3 signaling and reverses SOCS3‐mediated tumor suppression. We revealed that SOCS3‐low GSCs exhibit enriched p53 and JAK‐STAT pathway activity. This study provides new mechanistic insights into SOCS3‐STAT3 axis in
Jingtao Wang, Gaolei Hou, Zhaofei Song, Kai Gao, Hongbin Wang, Tao Li   +5 more
wiley   +1 more source

The m.14484T>C MT‐ND6 Mutation Presenting with a Hereditary Spastic‐Paraparesis Phenotype

Movement Disorders Clinical Practice, EarlyView.
Gabriel Amorelli, Christelle Nilles, Gerald Pfeffer, Matthew Joel, Davide Martino   +4 more
wiley   +1 more source