Results 41 to 50 of about 26,175 (228)

Reconstitution of T cell receptor signaling in ZAP-70-deficient cells by retroviral transduction of the ZAP-70 gene. [PDF]

, 1996
A variant of severe combined immunodeficiency syndrome (SCID) with a selective inability to produce CD8 single positive T cells and a signal transduction defect in peripheral CD4+ cells has recently been shown to be the result of mutations in the ZAP-70 ...
Bacon, KB, Gelfand, EW, Jahn, T, Kadlecek, TA, Kohn, DB, Smith, S, Taylor, N, Uribe, L, Weinberg, K, Weiss, A   +9 more
core   +1 more source

Anti-HTLV-I antibody and blood transfusion

Journal of Japanese Society for Dialysis Therapy, 1989
透析 (HD) 患者527名 (1988年1月) の血清中の抗HTLV-I抗体をゼラチン粒子凝集法 (particle agglutination test; PA法) およびWestern blotting (WB) 法にて測定し, 1984年5月332名, 1985年5月407名の結果と比較した. また, 1984年, 1985年, 1988年のPA陽性者の推移も合わせて検討した. 1986年11月より日本赤十字社にて抗HTLV-I抗体のスクリーニング検査が施行された. そこで, スクリーニング検査開始前, 後の抗体陽転者についても検討した. その結果,1.
Kaoru Igarashi, Kazunori Wakasugi, Shingo Yamane, Masaaki Sasaki, Kazuyoshi Tominaga, Takuo Nobuto, Nakanobu Azuma, Takao Matsugane, Mitsuru Suzuki   +8 more
openaire   +2 more sources

Development of Chimeric Antigen Receptor‐Modified NK Cells for the Immunotherapy of Adult T‐Cell Leukemia/Lymphoma

European Journal of Haematology, EarlyView.
ABSTRACT Adult T‐cell leukemia/lymphoma (ATL) is an aggressive hematological malignancy with a poor prognosis and limited therapeutic options. ATL cells exhibit aberrant surface glycosylation patterns resulting from dysregulated glycosyltransferase expression, representing a potentially tumor‐specific therapeutic target.
Yuichiro Uchida, Seigo Tateo, Masahiro Wakao, Hiroyuki Shinchi, Hayate Sawayama, Akira Fukumoto, Makoto Yoshimitsu, Yasuo Suda   +7 more
wiley   +1 more source

Plasma Elastase Screening in Hematological Disease Reveals Its Potential as a Diagnostic and Prognostic Biomarker in Hematological Malignancies

International Journal of Laboratory Hematology, EarlyView.
ABSTRACT Introduction Neutrophil‐extracellular traps are net‐like material released by triggered neutrophils and composed of decondensed chromatin linked to nuclear proteins. Elastase, one of the fourth most represented neutrophil‐specific serine proteases stored in azurophil granules of naïve neutrophils, exerts various actions, including degradation ...
Pasqualina Scala, Anna Maria Della Corte, Angela Bertolini, Marisa Gorrese, Francesca Picone, Bianca Serio, Danilo De Novellis, Laura Mettivier, Luca Pezzullo, Maria Carmen Martorelli, Denise Morini, Matteo D'Addona, Bianca Cuffa, Carmine Selleri, Valentina Giudice   +14 more
wiley   +1 more source

Human T-cell lymphotropic virus type II in Guaraní Indians, Southern Brazil Vírus linfotrópico de células T-humanas do tipo II em Índios Guaraní, Sul do Brasil

Cadernos de Saúde Pública, 2005
Human T-cell lymphotropic virus type II (HTLV-II) is found in many New World Indian groups on the American continent. In Brazil, HTLV-II has been found among urban residents and Indians in the Amazon region, in the North.
Marcio Menna-Barreto, Ana Ligia Bender, Sandro L. Bonatto, Loreta B. Freitas, Francisco M. Salzano, Luiza T. Tsuneto, Maria Luiza Petzl-Erler   +6 more
doaj   +1 more source

Aquaporin-4 Antibodies Are Not Related to HTLV-1\ud Associated Myelopathy [PDF]

, 2012
Introduction: The seroprevalence of human T-cell leukemia virus type 1 (HTLV-1) is very high among Brazilians (,1:200).\ud HTLV-1 associated myelopathy or tropical spastic paraparesis (HAM/TSP) is the most common neurological complication of\ud HTLV-1 ...
Brandão, Carlos Otávio, Casseb, Jorge Simão do Rosário, Damasceno, Alfredo, Damasceno, Benito P., Farias, Alessandro S., Jarius, Sven, Longhini, Ana Leda F., Moraes, Adriel S., Oliveira, Augusto C. Penalva de, Santos, Leonilda M. B., von Gleh, Felipe, Wandinger, Klaus-Peter, Wildemann, Brigitte   +12 more
core   +2 more sources

Innate Immune Activation Is a Strong Suppressor of CCL22 and Impedes Regulatory T Cell–Dendritic Cell Interaction

Immunology, EarlyView.
During homeostasis, CCL22 is secreted by dendritic cells (DC), which mediate contacts between regulatory T cells (Treg) and DC to maintain immune balance. Activation of innate immunity via microbes or pattern recognition receptor (PRR) agonists induces the secretion of several soluble factors (e.g., type I and II interferons, IL‐10), which mediate ...
Ignazio Piseddu, Jan Gärtig, Stephan Eiber, Stefan Moder, Raffael Thaler, Matthias Thaler, Juliane Gruen, Marlies Vornhülz, Kevin Bahner, Luana Messa, Benjamin Kühnemuth, Jennifer Müller, Konstantin Schnell, Antonia Beimert, Carolin Perleberg, Natascha Röhrle, Maximilian Martin Ludwig Knott, Linda Hammann, Vanessa Wittmann, Patrick Layritz, Moritz Rapp, Carole Bourquin, Julia Mayerle, Stefan Endres, David Anz   +24 more
wiley   +1 more source

Prevalence of anti-HTLV-I & anti-HTLV-II antibodies in Blood donors in Bushehr Province

Iranian South Medical Journal, 2004
Human T-cll leukemia virus type 1 (HTLV-I) and HTLV-II are type C oncoviruses, members of the family Retroviridae. Blood transfusion is a transmission route. Screening for HTLV is routine in Khorasan Province/Iran.
Mahmood Reza Poukarim, Gholamreza Khamisipour, Keyvan Zandi, Mohammad Hasan Roustaee   +3 more
doaj  

Translation inhibition by rocaglates is independent of eIF4E phosphorylation status [PDF]

, 2016
Rocaglates are natural products that inhibit protein synthesis in eukaryotes and exhibit antineoplastic activity. In vitro biochemical assays, affinity chromatography experiments coupled with mass spectrometry analysis, and in vivo genetic screens have ...
Cencic, Regina, Chu, Jennifer, Pelletier, Jerry, Porco, John A., Wang, Wenyu   +4 more
core   +1 more source

Re‐entry of donors deferred for false‐reactive screening tests in Canada: 10 years post implementation

Vox Sanguinis, EarlyView.
Abstract Background and Objectives Canadian Blood Services implemented a re‐entry programme in 2014. Donors deferred because of false‐reactive or indeterminate screening tests can provide a specimen for re‐entry testing 6 months after their initial test, and resume donating if they test negative for all infectious markers.
Chinchin Wang, Steven J. Drews, Mark Bigham, Mindy Goldman, Sheila F. O'Brien   +4 more
wiley   +1 more source