Results 71 to 80 of about 26,175 (228)

Sequential, chromosome‐specific glutamine synthetase double knockout with Cas‐CLOVER establishes enhanced CHO platforms for cell line development

Biotechnology Progress, Volume 42, Issue 2, March/April 2026.
This study established the first creation of a commercially available double GS knockout (DKO) from a single KO in CHO‐K1 cells, called CleanCut GS CHO using Cas‐CLOVER. When combined with the Harbor‐IN transposase system, CleanCut GS CHO cells demonstrated a highly antibody productivity.
Cintia Gomez Limia, Valeriya Steffey, Hsueh Che Cheng, Daniel Machado, Thomas Hart, Mark Cameron McHargue, Corey Brizzee, Jack Crawford   +7 more
wiley   +1 more source

Immunofluorescence assay reactivity patterns of serum samples presenting indeterminate Western blot results for antibodies to HIV-1 and HTLV-I/II in Cordoba, Argentina

Revista do Instituto de Medicina Tropical de São Paulo, 2001
Serum samples (n: 110) from blood donors and high risk individuals from Cordoba, Argentina with indeterminate HIV-1 and HTLV-I/II Wb profiles were studied for specific antibodies to HTLV-I/II and HIV-1 by indirect immunofluorescence assay (IFA) and for ...
René GASTALDELLO, Sandra GALLEGO, María Beatriz ISA, Eduardo MATURANO, Santos SILEONI, Silvia NATES, Silvia MEDEOT   +6 more
doaj  

Molecular and Phylogenetic Evidence of Interfamilial Transmission of HTLV-1 in the Afro-Descendant Community of São José de Icatú in the Brazilian Amazon

Viruses
This study aimed to describe the prevalence of HTLV-1/2 in quilombola communities in the state of Pará and investigate the possible sociodemographic risk factors associated with the infection, as well as to trace the occurrence of the familial ...
Bruno José Sarmento Botelho, Wandrey Roberto dos Santos Brito, Gabriel dos Santos Pereira Neto, Janete Silvana Souza Gonçalves, Bruna Maria Silva Oliveira, Camille Marcela Camarinha de Oliveira, Aline Cecy Rocha de Lima, Sandra Souza Lima, Priscila de Nazaré Quaresma Pinheiro, Felipe Bonfim Freitas, João Farias Guerreiro, Ricardo Ishak, Antonio Carlos Rosário Vallinoto, Izaura M. Vieira Cayres Vallinoto   +13 more
doaj   +1 more source

A preclinical model for the ATLL lymphoma subtype with insights into the role of microenvironment in HTLV-1-mediated lymphomagenesis [PDF]

, 2018
\uef7f View references (83) Adult T cell Leukemia/Lymphoma (ATLL) is a mature T cell malignancy associated with Human T cell Leukemia Virus type 1 (HTLV-1) infection.
Adriana Mattiolo, Alberto Amadori, Alberto Amadori, Barbara Montini, Ilaria Cavallari, Luigi Chieco-Bianchi, Maria Assunta Piano, Maria Luisa Calabrò, Mattia Vicario   +8 more
core   +2 more sources

Mechanistic role of GNE‐987 targeting BRD4‐HCP5 axis in pediatric T‐cell acute lymphoblastic leukemia

Journal of Cell Communication and Signaling, Volume 20, Issue 1, March 2026.
Abstract This study aims to explore the mechanism of action of the Bromodomain‐containing protein 4 (BRD4) inhibitor GNE‐987 in the treatment of pediatric T‐cell Acute Lymphoblastic Leukemia (T‐ALL), focusing on its effect in inhibiting T‐ALL cell proliferation by activating the HLA Complex P5 (HCP5) Super‐enhancer.
Xu Sang, Mengying Jiang, Yanchun Guan, Xin Chen, Zhen Zhang, Yumeng Wu, Wansheng Peng   +6 more
wiley   +1 more source

Antibody to Heat Shock Protein 70 (HSP70) Inhibits Human T-Cell Lymphoptropic Virus Type I (HTLV-I) Production by Transformed Rabbit T-Cell Lines

Toxins, 2012
Adult T cell leukemia is a fatal malignant transformation caused by the human T-cell lymphoptropic virus type I (HTLV-I). HTLV-I is only associated with the development of this disease in a small percentage of infected individuals.
Hanan Fallouh, Wahib Mahana
doaj   +1 more source

Helminths as architects of trained tolerance: implications for human health

Clinical &Translational Immunology, Volume 15, Issue 3, 2026.
Abstract Helminths infect nearly 2 billion people worldwide and are a major cause of chronic morbidity in low‐resource regions. Unlike bacterial and viral pathogens that elicit protective memory, helminths actively remodel host immunity to enable their years‐long persistence and reinfection.
Quinn Moroz, Jorge Lucas Nascimento Souza, Neima Briggs   +2 more
wiley   +1 more source

Retrospective Analysis of Blood Donor Deferral Reasons and Optimization Suggestions for Deferral Policies

iLABMED, Volume 4, Issue 1, Page 37-46, March 2026.
This retrospective study analyzes the deferral reasons for 148,282 blood donors during 2019–2023 (overall deferral rate: 12.37%), identifying primary deferral reasons (e.g., elevated ALT for temporary deferral at 51.33%, HBsAg positivity for permanent deferral at 4.12%).
Limei Feng, Li Liu, Rui Wang, Ting Zhang, Wei Guo, Yang Yu   +5 more
wiley   +1 more source

Role of CD4 epitopes outside the gp120-binding site during entry of human immunodeficiency virus type 1 [PDF]

, 1997
CD4 is the primary receptor for human immunodeficiency virus (HIV). The binding site for the surface glycoprotein of HIV type 1 (HIV-1), gp120, has been mapped to the C'-C" region of domain 1 of CD4. Previously, we have shown that a mutant of rat CD4, in
Simon, J.H.M, Stumbles, P.A., Signoret, N., Somoza, C., Puklavec, M., Sattentau, Q.J., Barclay, A.N., James, W.   +7 more
core   +1 more source

Rhetoric and the AIDS Virus Hunt [PDF]

, 1998
By comparing the papers produced by the laboratory teams of Robert Gallo and Jean Luc Montagnier during the AIDS virus hunt, we have an opportunity to discern the fine line between a bold, explicit rhetoric that may convince as well as offend and a bald,
Reeves, Carol
core   +2 more sources