Results 51 to 60 of about 48,838 (229)

Ancient, independent evolution and distinct molecular features of the novel human T-lymphotropic virus type 4

Retrovirology, 2009
Background Human T-lymphotropic virus type 4 (HTLV-4) is a new deltaretrovirus recently identified in a primate hunter in Cameroon. Limited sequence analysis previously showed that HTLV-4 may be distinct from HTLV-1, HTLV-2, and HTLV-3, and their simian ...
Wolfe Nathan D, Pryor Kendle N, Marriott Susan J, Katzourakis Aris, Gray Rebecca R, Jia Hongwei, Qari Shoukat H, Salemi Marco, Switzer William M, Burke Donald S, Folks Thomas M, Heneine Walid   +11 more
doaj   +1 more source

Integrated Engineering of CAR‐T Cells for Solid Tumours

Cell Proliferation, EarlyView.
Solid tumours pose multifactorial barriers including antigen heterogeneity, immunosuppressive microenvironment, and poor T‐cell trafficking, limiting CAR‐T efficacy compared to hematologic malignancies. Integrated engineering strategies are essential, combining logic‐gated receptors for precision, metabolic‐epigenetic reprogramming for resilience, and ...
Chao Yang, Tan Li, Ping He, Zhijie Zhao, Shenglong Li, Liming Wang   +5 more
wiley   +1 more source

Trends in the prevalence and distribution of HTLV-1 and HTLV-2 infections in Spain

Virology Journal, 2012
Background Although most HTLV infections in Spain have been found in native intravenous drug users carrying HTLV-2, the large immigration flows from Latin America and Sub-Saharan Africa in recent years may have changed the prevalence and distribution of ...
Treviño Ana, Aguilera Antonio, Caballero Estrella, Benito Rafael, Parra Patricia, Eiros Jose M, Hernandez Araceli, Calderón Enrique, Rodríguez Manuel, Torres Alvaro, García Juan, Ramos Jose, Roc Lourdes, Marcaida Goitzane, Rodríguez Carmen, Trigo Matilde, Gomez Cesar, de Lejarazu Raul, de Mendoza Carmen, Soriano Vincent   +19 more
doaj   +1 more source

Innate Immune Activation Is a Strong Suppressor of CCL22 and Impedes Regulatory T Cell–Dendritic Cell Interaction

Immunology, EarlyView.
During homeostasis, CCL22 is secreted by dendritic cells (DC), which mediate contacts between regulatory T cells (Treg) and DC to maintain immune balance. Activation of innate immunity via microbes or pattern recognition receptor (PRR) agonists induces the secretion of several soluble factors (e.g., type I and II interferons, IL‐10), which mediate ...
Ignazio Piseddu, Jan Gärtig, Stephan Eiber, Stefan Moder, Raffael Thaler, Matthias Thaler, Juliane Gruen, Marlies Vornhülz, Kevin Bahner, Luana Messa, Benjamin Kühnemuth, Jennifer Müller, Konstantin Schnell, Antonia Beimert, Carolin Perleberg, Natascha Röhrle, Maximilian Martin Ludwig Knott, Linda Hammann, Vanessa Wittmann, Patrick Layritz, Moritz Rapp, Carole Bourquin, Julia Mayerle, Stefan Endres, David Anz   +24 more
wiley   +1 more source

HTLV-1/2 proviral load by sex and age among rural population in Gabon, central Africa.

, 2018
Rectangle: Average magnitude of HTLV1/2 proviral load; Line: Median proviral load; Bar: Standard deviation. HTLV-1/2 proviral load was measured by a multiplex real-time PCR assay involving a molecular beacon probe for simultaneous detection ...
Maria Makuwa (131491), Guillaume Besson (313049), Melanie Caron (2558596), Eric Leroy (264004), Dieudonne Nkoghe (3404600), Cindy Padilla (201518), Mirdad Kazanji (136517)   +6 more
core   +1 more source

Harnessing the Therapeutic Potential of Cell Secretomes and Extracellular Vesicles for Craniofacial Regenerative Applications

Journal of Periodontal Research, EarlyView.
The scoping review summarizes the current preclinical and clinical evidence for the use of “cell‐free” therapies in craniofacial (periodontal, bone and soft‐tissue) regeneration. It also aims to highlight key challenges and strategies towards the clinical translation of these therapies.
Siddharth Shanbhag, Magdalena Mayol, Danijel Domic, Madhusudhan Reddy Bobbili, Johannes Grillari, Mariano Sanz, Reinhard Gruber   +6 more
wiley   +1 more source

Epidemiological analysis of HTLV-1 and HTLV-2 infection among different population in Central China. [PDF]

PLoS ONE, 2013
BACKGROUND: HTLV-1 and HTLV-2 are retroviruses linked etiologically to various human diseases, and both of them can be transmitted by vertical route, sexual intercourse, blood transfusion and intravenous drug use.
Yunyun Ma, Shangen Zheng, Na Wang, Yu Duan, Xinyu Sun, Jing Jin, Wenqiao Zang, Min Li, Yuanyuan Wang, Guoqiang Zhao   +9 more
doaj   +1 more source

HTLV screening and confirmatory testing among blood donors in São Paulo: A cross‐sectional study

Transfusion Medicine, EarlyView.
Abstract Introduction Human T‐cell lymphotropic virus types 1 and 2 (HTLV‐1/2) are transfusion‐transmissible retroviruses associated with severe diseases, and blood donor screening is mandatory in Brazil. Increasing HTLV‐related discard rates at our institution prompted this study to determine the prevalence and incidence of HTLV‐1/2 and to investigate
Suzete C. Ferreira, Anna S. Nishyia, Jerenice E. Ferreira, Claudia Di Lorenzo Oliveira, Cesar de Almeida‐Neto, Tila Fanciani, Katia C. Dantas, Juliana Derriga, Silvia Petrossi Gallo Polato, Nanci Salles, Vanderson Rocha, Alfredo Mendrone‐Junior   +11 more
wiley   +1 more source

Functional interactions of the Tax and p13 proteins of Human T-cell Leukemia Virus Type I [PDF]

, 2013
Human T-cell leukemia virus type 1 (HTLV-1) establishes a lifelong persistent infection in humans. Approximately 3% of the infected individuals will develop adult T-cell leukemia/lymphoma (ATLL), an aggressive malignancy of mature CD4+ T-cells. The viral
Manicone, Mariangela
core  

HTLV-1⁺ subjects and PBMCs examined in this study.

, 2019
HTLV-1+ subjects and PBMCs examined in this study.
Michi Miura (144400), David S. Rueda (7879094), Saumya Ramanayake (7879091), Supravat Dey (3929246), Charles R. M. Bangham (7879097), Abhyudai Singh (503811)   +5 more
core   +1 more source