Huangkui capsules regulate tryptophan metabolism to improve diabetic nephropathy through the Keap1/Nrf2/HO-1 pathway [PDF]
Frontiers in PharmacologyBackgroundDiabetic nephropathy (DN) is a serious complication of diabetes and one of the leading causes of end-stage renal disease. Huangkui capsule (HKC), a traditional Chinese patent medicine, is widely used in clinical practice for the treatment of ...
Liu Shijia
exaly +6 more sources
Uncovering the mechanism of Huangkui capsule in the treatment of diabetic kidney disease based on network pharmacology and experimental validation [PDF]
Scientific ReportsDiabetic kidney disease (DKD) is a main complication of diabetes mellitus. experimental in vitro validation and Network pharmacology were used in this study to explore the potential mechanism of Huangkui capsules (HKC) in treating DKD.
Ziwei Li +2 more
exaly +5 more sources
Huangkui Capsule in Combination with Leflunomide Improves Immunoglobulin A Nephropathy by Inhibiting the TGF-β1/Smad3 Signaling Pathway [PDF]
Clinics, 2021 OBJECTIVES: To investigate the efficacy and potential molecular mechanism of Huangkui capsule in combination with leflunomide (HKL) for the treatment of immunoglobulin A nephropathy (IgAN) METHODS: IgAN rat models were constructed by treating rats with ...
Shuwen Pei
exaly +7 more sources
Clinical Efficacy of Huangkui Capsule Plus Methylprednisolone for Immunoglobulin A Nephropathy and Its Effect on Renal Function and Serum Inflammatory Factors. [PDF]
Evid Based Complement Alternat Med, 2023 Objective. To assess the clinical efficacy of Huangkui capsule plus methylprednisolone for immunoglobulin A (IgA) nephropathy and its effect on renal function and serum inflammatory factors. Methods. A total of 80 patients with IgA nephropathy admitted to our hospital from April 2019 to December 2021 were recruited and assigned (1 : 1) to receive ...
Yuan L, Cai K, Zou Y.
europepmc +4 more sources
Evid Based Complement Alternat Med, 2022 Objective. The study aimed to assess the clinical efficacy of Huangkui capsule plus methylprednisolone in the treatment of nephropathy and the effect on urinary protein and serum inflammatory factors in patients. Methods. Between June 2017 and July 2020, 90 patients with nephropathy admitted to our hospital were recruited after ...
Wan W +8 more
europepmc +4 more sources
Evaluation of the efficacy of Abelmoschus manihot (L.) on diabetic nephropathy by analyzing biomarkers in the glomeruli and proximal and distal convoluted tubules of the kidneys [PDF]
Frontiers in Pharmacology, 2023 Introduction: As a traditional Chinese medicine, Abelmoschus manihot (L.) in the form of Huangkui (HK) capsule has been used as a medication for kidney diseases, including diabetic nephropathy (DN), in China.
Hongmei Yu +11 more
doaj +2 more sources
Differential efficacy and anti-inflammatory mechanisms of Bailing Preparations versus Huangkui Capsules combined with SGLT-2 inhibitors for diabetic kidney disease: a network meta-analysis and GRADE assessment [PDF]
Frontiers in PharmacologyBackgroundWhile sodium-glucose cotransporter 2 (SGLT-2) inhibitors serve as the cornerstone of therapy for diabetic kidney disease (DKD), a specific subset of patients continues to face residual risks, manifested as persistent proteinuria or declining ...
Xinyu Li, Xiao Yuan, Zhiyu Wu
doaj +2 more sources
Network pharmacology and molecular docking predictions of the active compounds and mechanism of action of Huangkui capsule for the treatment of idiopathic membranous nephropathy. [PDF]
Medicine (Baltimore), 2023 Background: Huangkui Capsule is a single herbal concoction prepared from the flower of Abelmoschus manihot, which is used to treat idiopathic membranous nephropathy (IMN), a frequent pathologically damaging kidney condition. It has been widely utilized to treat a variety of renal disorders, including IMN, in clinical practice ...
Cai M, Xiang Y, Li Z, Xie J, Wen F.
europepmc +3 more sources
Huangkui Capsule Attenuates Lipopolysaccharide-Induced Acute Lung Injury and Macrophage Activation by Suppressing Inflammation and Oxidative Stress in Mice [PDF]
Evidence-Based Complementary and Alternative Medicine, 2021 Background. Huangkui capsule (HKC) comprises the total flavonoid extract of flowers of Abelmoschus manihot (L.) Medicus. This study aimed to explore the effects of HKC on lipopolysaccharide- (LPS-) induced acute lung injury (ALI) in mice and LPS-stimulated RAW 264.7 cells. Methods.
Jinfang Deng +8 more
openaire +3 more sources
Efficacy and safety of Huangkui capsule for diabetic nephropathy: A systematic review and meta-analysis. [PDF]
Medicine (Baltimore)Background: To systematically evaluate the efficacy and safety of Huangkui capsule (HKC) in the treatment of diabetic nephropathy (DN). Methods: A computerized search of 8 online databases, CNKI, VIP, WANGFANG, CBM, ChiCTR, Embase, PubMed, and Cochrane Library, was conducted from ...
Li Y, Wu C, Song C, Liu S, Nan Z.
europepmc +3 more sources