Results 201 to 210 of about 222,469 (240)

Integrated bioinformatics analysis reveals cross-talking hub genes and therapeutic agents between sepsis and acute myocardial infarction. [PDF]

Ann Med
Zhou L, Chen W, Li J, Chen M.
europepmc   +1 more source

BCR::ABL1‐Induced Enhancer Reprogramming Uncovers Hypersensitivity of Ph+B‐ALL Cells to Enhancer‐Targeting Drugs

Advanced Science, EarlyView.
Ng et al. show that the BCR::ABL1 kinase that drives the lymphoid leukemia Ph+B‐ALL modulates enhancer function by coopting signaling‐inducible transcription factors such as MYC, STAT5, and ETV5. BCR::ABL1 thereby promotes the transcriptional program driving and defining this leukemia and renders Ph+B‐ALL cells hypersensitive to enhancer‐inhibiting ...
Han Leng Ng, Trudy Lee Glaser, Jintao Zhu, Mark E. Robinson, Kadriye N. Cosgun, Valeriya Malysheva, Ozgen Deniz, Nicholas T. Crump, Kaiyue Helian, Andrew J. Innes, Richard Burt, Li Sun, George John, Haibin Zhou, Atsunori Kaneshige, Longchuan Bai, Shaomeng Wang, Mikhail Spivakov, Markus Müschen, Niklas Feldhahn   +19 more
wiley   +1 more source

Respiratory‐Limbic Coupling via a Thalamic Circuit Alleviates Anxiety

Advanced Science, EarlyView.
This study delineates a conserved preBötCGlu→PVT→CeA circuit that gates anxiety and respiration. Activation of this circuit is anxiolytic and respiratory‐stabilizing, while its inhibition has the opposite effect. Mechanistically, PVT exerts its anxiolytic action via a disinhibitory microcircuit: its inputs preferentially target CeL GABAergic neurons ...
Shangyu Bi, Xiaoyi Wang, Huichun Luo, Ziteng Yue, Tianjiao Deng, Yuhang Liu, Xinxin Chen, Jianxu Zhao, Luo Shi, Ning Ma, Lingyan Mao, Jing Ding, Jiwen Xu, Ti‐Fei Yuan, Sheng Wang, Fang Yuan   +15 more
wiley   +1 more source

CITED2: a novel hub gene downregulated in Hashimoto's thyroiditis and associated with M1 macrophages via bioinformatics analysis and clinical validation. [PDF]

Front Immunol
Bai X, Duan H, Xu Y, Shi H, Huang H.
europepmc   +1 more source

Gene screening and immune phenotype shifts of osteoporosis. [PDF]

Sci Rep
Hu X, Tian L.
europepmc   +1 more source

Integrative bioinformatics analyses of mitochondrial dysfunction-related genes in human non-obstructive azoospermia. [PDF]

Sci Rep
Liu Q, Wu H, You J, Wang J, Peng X, Ye Z, Wu M.   +6 more
europepmc   +1 more source

m5C: Novel Diagnostic and Drug Repurposing Targets for Nonalcoholic Steatohepatitis. [PDF]

Int J Genomics
Chen S, Duan R, Qiu J, Lei Z, Chen W, Li X.   +5 more
europepmc   +1 more source

Piloting the feasibility of a population-based joint TB-HIV survey in KwaZulu-Natal Province, South Africa, 2019. [PDF]

PLOS Glob Public Health
Murangandi P, Oladimeji O, Zungu N, Makola L, Marinda E, Simbayi L, Zuma K, Ramlagan S, Jooste S, Maseko G, Naidoo I, Nwosu C, McCracken S, Moyo S, Hladik W.   +14 more
europepmc   +1 more source