Results 81 to 90 of about 21,404 (260)

B4GALNT4‐Mediated Glycosylation of PDK1 Activates the PI3K‐AKT Signaling Pathway to Promote Prostate Cancer Progression

Advanced Science, EarlyView.
This study identifies B4GALNT4 as a key driver of prostate cancer (PCa). It shows that B4GALNT4 glycosylates PDK1 protein at the N531 site, which stabilizes the PDK1 and constitutively activates the PI3K‐AKT pathway. This mechanism promotes tumor cell proliferation, migration, and invasion. The findings establish the B4GALNT4‐PDK1 glycosylation axis as
Shaoqin Jiang, Mengqiang Li, Qingfu Su, Ruiling Dou, Shaoshan Lin, Jili Zhang, Xiaochen Sun, Haolan Yu, Wei Bao, Min Qu, Yan Wang, Chenghua Yang, Xu Gao   +12 more
wiley   +1 more source

Hierarchy of Hub Covering Problems

Hub Covering Problems arise in various practical domains, such as urban planning, cargo delivery systems, airline networks, telecommunication network design, and e-mobility. The task is to select a set of hubs that enable tours between designated origin-destination pairs while ensuring that any tour includes no more than two hubs and that either the ...
openaire   +2 more sources

Mesoscale Recovery of Microglial and Neuronal Dynamics After Craniotomy Across Wide Cortex in Transgenic Mice

Advanced Science, EarlyView.
This study employs longitudinal fluorescence imaging in transgenic mice to map post‐craniotomy cortical recovery. We identify distinct neuroimmune recovery phases: microglial structural inflammation peaks at ∼10 days, neuronal structural intensity peaks at ∼14 days and correlates with microglial activity, and functional network modularity is most ...
Guihua Xiao, Zhilei Wang, Pengchang Zheng, Jingyu Xie, Yangzhen Wang, Yun Chen, Zilin Wang, Ao Li, Minghuan Wang, Quanbo Ji, Can Gao, Di Yao, Lingbo Li, Jiangbei Cao   +13 more
wiley   +1 more source

Dynamic + maximal hub location problem for freight transportation planning with rational markets

Advances in Mechanical Engineering, 2019
In this article, a dynamic maximal hub location covering problem for a freight transportation system is studied, in which the model has the possibility of having expansion scenarios for future according to the forecasts of increasing demands.
Roghayyeh Alizadeh, Tatsushi Nishi
doaj   +1 more source

Strong hub cover pebbling number

In a graph $G$, we define a set of vertices to be a \emph{strong hub set} if for any two vertices in $G$, we can find a path between them whose internal vertices are all in this set. We define the \emph{strong hub cover pebbling number} of $G$, denoted by $h_s^*(G)$, to be the smallest $t$ such that for any initial configuration with $t$ pebbles on $G$,
openaire   +2 more sources

Hierarchical Summary Statistics Encoding Across Primary Visual and Posterior Parietal Cortices

Advanced Science, EarlyView.
This study shows that mouse V1 simultaneously encodes the ensemble mean and variance of motion, providing a robust summary‐statistic representation that persists despite single‐neuron variability. These signals propagate to PPC, where they are transformed into abstract category representations during decision making.
Young‐Beom Lee, Oliver James, Gaeun Jung, Doyun Lee, Yee‐Joon Kim   +4 more
wiley   +1 more source

Capacitated Location-Allocation Hub Covering Problem in Manufacturing-Customer Interaction [PDF]

Journal of Applied & Computational Mathematics, 2015
This paper presents a location-allocation hub covering considering capacity constraints for multiple hubs and allocates non-hub nodes including the manufacturer and the customer. The model is an integer linear programming minimizing the transfer costs and optimizes the allocation requests from the manufacturer to the customer passing through one or two
openaire   +1 more source

Loss of SOCS1 in Donor T Cells Exacerbates Intestinal GVHD by Driving a Chemokine‐Dependent Pro‐Inflammatory Immune Microenvironment

Advanced Science, EarlyView.
T cell‐specific Socs1 knockout leads to inflammatory differentiation of CD8+ T cells, prompting the STAT1/2 complex to drive the activation of Ccl5, Ccr5, and Cxcr3, and promoting the skewing of monocytes toward a pro‐inflammatory M1 macrophage lineage.
Zhigui Wu, Bixia Wang, Xinya Jiang, Fangqing Zhang, Qianqian Huang, Xinyi Wu, Shuang Fan, Qi Zhang, Jingrui Zhou, Jianing Tang, Xiao‐Dong Mo, Yu Wang, Ying‐Jun Chang, Huidong Guo, Xiao‐Jun Huang   +14 more
wiley   +1 more source

Modulating Integrin and Growth Factor Signaling With Peptides: Strategies to Synergistically Enhance Bone Tissue Regeneration

Advanced Science, EarlyView.
It has been demonstrated that, in the bone extracellular matrix (ECM), integrins and growth factor receptors (GFRs) engage in synergistic signaling to guide bone healing and regeneration. This review provides a comprehensive overview of current strategies using ECM‐derived peptides to recreate the cellular microenvironment and harness synergistic ...
Lluís Oliver‐Cervelló, Elisabetta Ada Cavalcanti‐Adam, Carlos Mas‐Moruno   +2 more
wiley   +1 more source

Hub Cover and Hub Center Problems

, 2005
Using covering problems (CoP) combined with binary search is a well-known and successful solution approach for solving continuous center problems. In this thesis, we show that this is also true for center hub location problems in networks. We introduce and compare various formulations for hub covering problems (HCoP) and analyse the feasibility ...
openaire   +2 more sources