Results 31 to 40 of about 7,009 (230)

The incomplete hub-covering location problem considering imprecise location of demands

Scientia Iranica, 2021
AbstractFacility location is a prime decision to be made in many organizations around the globe. The hub location problem is one of the main variants of the facility location problem, with applications in telecommunications, the airline industry, and etc.
Zarandi, Mohammad Hossein Fazel, Davari, S., Türkşen, İsmail Burhan   +2 more
openaire   +2 more sources

Machine‐Learning Decomposition Identifies a Big Two Structure in Human Personality with Distinct Neurocognitive Profiles

Advanced Science, EarlyView.
Using machine learning on a mega‐scale global dataset (n = 1,336,840) reveals a robust personality trait architecture beyond the Big Five. A Big Two model, broadly capturing social engagement and internal mentation, defines a geometric space that links personality to neurocognitive profiles.
Kaixiang Zhuang, Ji Chen, Jinfeng Han, Wei Cheng, Jiang Qiu, Jianfeng Feng, Simon Eickhoff, Deniz Vatansever   +7 more
wiley   +1 more source

Hierarchical Summary Statistics Encoding Across Primary Visual and Posterior Parietal Cortices

Advanced Science, EarlyView.
This study shows that mouse V1 simultaneously encodes the ensemble mean and variance of motion, providing a robust summary‐statistic representation that persists despite single‐neuron variability. These signals propagate to PPC, where they are transformed into abstract category representations during decision making.
Young‐Beom Lee, Oliver James, Gaeun Jung, Doyun Lee, Yee‐Joon Kim   +4 more
wiley   +1 more source

A Bi-Objective Mathematical Programming Model for a Maximal Covering Hub Location Problem Under Uncertainty

SAGE Open
Properly locating these facilities is a substantial factor in the success of the logistics systems. In this paper, a bi-objective mathematical model for a maximal covering hub location problem is presented to minimize time and environmental risks.
Mohammad Khalilzadeh, Mahsa Ahmadi, Omid Kebriyaii   +2 more
doaj   +1 more source

Modulating Integrin and Growth Factor Signaling With Peptides: Strategies to Synergistically Enhance Bone Tissue Regeneration

Advanced Science, EarlyView.
It has been demonstrated that, in the bone extracellular matrix (ECM), integrins and growth factor receptors (GFRs) engage in synergistic signaling to guide bone healing and regeneration. This review provides a comprehensive overview of current strategies using ECM‐derived peptides to recreate the cellular microenvironment and harness synergistic ...
Lluís Oliver‐Cervelló, Elisabetta Ada Cavalcanti‐Adam, Carlos Mas‐Moruno   +2 more
wiley   +1 more source

Approximating the minimum hub cover problem on planar graphs

Optimization Letters, 2015
zbMATH Open Web Interface contents unavailable due to conflicting licenses.
Yelbay, Belma, Birbil, Ş. İlker, Bülbül, Kerem, Jamil, Hasan M.   +3 more
openaire   +4 more sources

Ultrasound Controlled‐Release Hydrogel Promotes Diabetic Wound Healing via Neuroimmune Modulation and Synergistic ROS Scavenging

Advanced Science, EarlyView.
This study presents an ultrasound‐responsive hydrogel (MCF@CA) that co‐delivers a neuropeptide (CGRP) and a ROS‐scavenging manganese porphyrin to diabetic wounds. The system restores neuro‐immune communication, reprograms macrophages toward an anti‐inflammatory phenotype, and clears excess ROS, thereby accelerating wound closure and promoting mature ...
Mofan Li, Mengxin Wang, Haonan Wang, Yang Sun, Yongyue Zhang, Shuyu Xu, Tianjiao Zhang, Shiti Shama, Xiaolong Liang, Shumin Wang   +9 more
wiley   +1 more source

The stratified p-hub center and p-hub maximal covering problems

, 2022
Hub networks are the foundation of many transportation and distribution systems, and real-world hub networks often transport freight or passengers of different service classes. This paper introduces the stratified multiple allocation p-hub center and p-hub maximal covering problems where the traffic corresponding to each origin–destination (O/D) pair ...
Yetiş Kara, Bahar, Ghaffarinasab, N., Campbell, J. F.   +2 more
openaire   +2 more sources

A hub covering network design problem for cargo applications in Turkey [PDF]

Journal of the Operational Research Society, 2009
Hub location problems involve locating hub facilities and allocating demand nodes to hubs in order to provide service between origin–destination pairs. In this study, we focus on cargo applications of the hub location problem. Through observations from the Turkish cargo sector, we propose a new mathematical model for the hub location problem that ...
Alumur, S., Kara, B.Y.
openaire   +3 more sources

Humanized and Charge‐Optimized CSPG4‐Specific CAR‐T Cells show Enhanced Efficacy against Head and Neck Squamous Cell Carcinoma

Advanced Science, EarlyView.
CSPG4 is identified as a high‐value, stemness‐associated target in HPV‐negative HNSCC. By implementing rational biophysical engineering, a humanized and charge‐optimized CAR is developed to overcome tonic signaling‐induced exhaustion. This strategy induces a profound transcriptomic shift toward a rejuvenated, stem‐like memory state, significantly ...
Xiang Xu, Shizhen Qiu, Zhitong Wang, Dan Li, Min Chen, Yinying Chu, Guangfei Li, Yi Fang, Changjiang Li, Fang Shi, Peijie He, Haitao Wu, Haopeng Wang, Jian Chen   +13 more
wiley   +1 more source