Results 41 to 50 of about 392,674 (301)
FEBS Letters, EarlyView.Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil +4 more
wiley +1 more source
pH‐mediated activation of the lysosomal arginine sensor SLC38A9
FEBS Letters, EarlyView.Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley +1 more source
Robust Hub Location Problem With Flow-Based Set-Up Cost
IEEE Access, 2020 Hub location problems are network design problems on the level of strategic decision-making processes. During strategic planning, input data, such as flows and set-up costs, are not always known in advance.
Shuxia Li, Chenhao Fang, Yifan Wu
doaj +1 more source
Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source
Anytime Algorithms for Multi-Objective Hub Location Problems [PDF]
, 2018 In many logistic, telecommunications and computer networks, direct routing of commodities between any origin and destination is not viable due to economic and technological constraints.
Chicano, Francisco +3 more
core
Star p-hub median problem with modular arc capacities [PDF]
, 2007 Cataloged from PDF version of article.We consider the hub location problem, where p hubs are chosen from a given set of nodes, each nonhub node is connected to exactly one hub and each hub is connected to a central hub.
Yaman, H.
core +2 more sources
Molecular Oncology, EarlyView.Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson +9 more
wiley +1 more source
Solving Multi-Objective Hub Location Problems with Robustness [PDF]
, 2019 Hub location problems (HLP) are considered in many logistic, telecommunications, and computer problems, where the design of these networks are optimized based on some objective(s) related to the cost or service. In those cases, direct routing between any
Chicano, Francisco +3 more
core
Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer
Molecular Oncology, EarlyView.Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni +11 more
wiley +1 more source
WHOOPH: whale optimization-based optimal placement of hub node within a WBAN
Scientific ReportsBiosensor nodes of a wireless body area network (WBAN) transmit physiological parameter data to a central hub node, spending a substantial portion of their energy.
Shubham Shukla +7 more
doaj +1 more source