Results 51 to 60 of about 392,674 (301)
Solving multi-objective hub location problems by hybrid algorithms [PDF]
, 2018 In many logistic, telecommunications and computer networks, direct routing of commodities between any origin and destination is not viable due to economic and technolog- ical constraints.
Chicano, Francisco +3 more
core
Molecular Oncology, EarlyView.EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain +10 more
wiley +1 more source
International Journal of Distributed Sensor Networks, 2018 Integration of urban and rural infrastructure is critical to integrating urban and rural public transport. A public transport hub is an important element of infrastructure, and it is the key facilities that serve as transferring points between cities and
Wei Zhong +3 more
doaj +1 more source
Capacitated single allocation hub location problem--A bi-criteria approach [PDF]
, 2008 A different approach to the capacitated single allocation hub location problem is presented. Instead of using capacity constraints to limit the amount of flow that can be received by the hubs, we introduce a second objective function to the model ...
Captivo, Maria Eugénia +2 more
core +1 more source
Molecular Oncology, EarlyView.CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak +10 more
wiley +1 more source
AlgorithmsToday, facility location planning primarily pertains to the long-term strategic and operational decision-making of large public and private organizations, and the significant costs associated with facility location, construction, and operation have ...
Salar Babaei +3 more
doaj +1 more source
Mass spectrometry based identification of AMP‐O‐Tris generated by Thermococcus onnurineus Cas10
FEBS Open Bio, EarlyView.Isolated Thermococcus onnurineus Cas10 generates the noncanonical ATP‐derived product AMP‐O‐Tris while in Tris‐containing buffer as identified via mass spectrometry, revealing relaxed nucleophile selectivity under isolated conditions. These findings suggest that multiprotein Csm complex assembly restricts Cas10 reactivity toward canonical cyclic ...
Su‐Jin Lee +6 more
wiley +1 more source
Model Hub Median Problem Dengan Batasan Travel Time
Jurnal Teknik Industri, 2017 This article describes the development of an uncapacitated p-hub median problem model. The established model will be applied in determining the location of the hub.
Faisal Ibrahim, Ahmad Rusdiansyah
doaj +1 more source
Optimizing tuning masses for helicopter rotor blade vibration reduction including computed airloads and comparison with test data [PDF]
The development and validation of an optimization procedure to systematically place tuning masses along a rotor blade span to minimize vibratory loads are described.
Bingham G.J. +17 more
core +2 more sources
Why human connection is the true metric of research success
FEBS Open Bio, EarlyView.Human‐centred mentorship can be shaped by mentor attributes, actions, intrinsic drive and career ambition. Drawing on reflections across Singapore and France, as well as workshop insights from FEBS‐IUBMB ENABLE 2024, this article shows that human‐centred mentorship creates the conditions for sustainable growth, well‐being and retention in research ...
Timothy Lin Yun Tan +3 more
wiley +1 more source