Results 41 to 50 of about 15,337,946 (244)
Integration across a metacoupled world
Ecology and Society, 2017 Human-nature interactions are complex and have important implications for achieving sustainable development goals and addressing other global challenges.
Jianguo Liu
doaj +1 more source
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
Beyond Subsistence. Human-Nature Interactions [PDF]
Different perspectives aiming to understand the complex relationship of humans and resources were the main focus of the international workshop ‘Beyond Subsistence: Human-Nature Interactions’, which took place within the initiatives of the Collaborative ...
Kitagawa, Keiko +3 more
core +1 more source
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
People and NatureFostering pro‐conservation attitudes and behaviour is essential to mitigating biodiversity decline. Biophobia—negative emotional responses, such as fear and disgust, towards living organisms—can shape these attitudes, but its effects remain poorly ...
Masari Date, Yuya Fukano, Masashi Soga
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DiversityOur research aims to examine the level of biodiversity knowledge among urban residents who engage in recreational activities in different natural areas of the Province of Concepción, Chile.
Carolina Hidalgo +3 more
doaj +1 more source
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
FEBS Letters, EarlyView.This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee +2 more
wiley +1 more source
Urgent Biophilia: Human-Nature Interactions and Biological Attractions in Disaster Resilience
Ecology and Society, 2012 This contribution builds upon contemporary work on principles of biological attraction as well as earlier work on biophilia while synthesizing literatures on restorative environments, community-based ecological restoration, and both community and social ...
Keith G. Tidball
doaj +1 more source
FEBS Letters, EarlyView.Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante +10 more
wiley +1 more source