Results 81 to 90 of about 15,337,946 (244)

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

Molecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim, Maryam Aslam, Elouise Torruella, Alphons Sony, Asif Rahman, Simira Smith, Columba de la Parra, Moira Sauane   +7 more
wiley   +1 more source

Reimagining Human–Nature Interactions Through the Lens of “Green Education Principles”

Philosophies
The research explores three interconnected themes: philosophy, education, and ecology. It aims to be an interdisciplinary study that emphasizes the significance of the philosophy of environmental education and its practical implications.
Dimitri Jan Jakubowski
doaj   +1 more source

The metacoupled Arctic: Human-nature interactions across local to global scales as drivers of sustainability. [PDF]

Ambio, 2022
Kapsar K, Frans VF, Brigham LW, Liu J.
europepmc   +1 more source

Regulation of the lncRNA NEAT1 by p53‐ΔNp63 crosstalk modulates the DNA damage response and therapeutic efficacy in HNSCC

Molecular Oncology, EarlyView.
In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico, Veronica La Banca, Silvia D'Amico, Stefano Scalera, Sara Nicolai, Angelo Peschiaroli   +5 more
wiley   +1 more source

Human–nature connectedness and sustainability across lifetimes: A comparative cross‐sectional study in France and Colombia

People and Nature
To achieve sustainable targets, international panels call for a transformative change in human–nature interactions to foster human well‐being and promote pro‐environmental behaviour.
Gladys Barragan‐Jason, Maxime Cauchoix, Paula A. Diaz‐Valencia, Arielle Syssau‐Vaccarella, Solène Hemet, Camilo Cardozo, Suzanne M. Skevington, Philipp Heeb, Camille Parmesan   +8 more
doaj   +1 more source

Extracellular matrix remodeling and immune reprogramming drive residual tumor progression of liver cancer after incomplete microwave ablation

Molecular Oncology, EarlyView.
Incomplete microwave ablation (iMWA) of liver cancer triggers a biphasic progression in residual tumors. At Day 3, the microenvironment is characterized by acute inflammatory responses and extracellular matrix (ECM) remodeling. By Day 14, a profound shift occurs toward oncogenic signal transduction and immunosuppression, marked by macrophage ...
Yu Liu, Yubei He, Nikolaus Berndt, Michael Mülleder, Kathrin Textoris‐Taube, Jing Guo, Matthias Stechele, Justus Ramtke, Shraga Nahum Goldberg, Lynn Jeanette Savic   +9 more
wiley   +1 more source

Nature Connections 2016 conference report: Implications for research and practice [PDF]

, 2017
A report of the key themes emerging from the Nature Connections 2016 conference drawing together researchers and practitioners from the field of human-nature ...
Hunt, Anne, Richardson, Miles, Lumber, Ryan, Harvey, Caroline   +3 more
core  

Unique circulating miRNAome signatures captured with distinct molecular states in Lynch syndrome and sporadic colorectal cancer

Molecular Oncology, EarlyView.
Circulating microRNA profiles distinguish nonmalignant Lynch syndrome from cancer‐associated Lynch syndrome, sporadic colorectal cancer, and healthy controls. Age‐stratified analysis reveals disease‐specific regulatory states, and a six‐miRNA panel shows concordant separation in an independent colorectal tissue cohort.
Ramadhani Salum Chambuso, Md Shohel Ul Islam, Rosa M Xicola, Raj Ramesar, Xavier Llor, Sinclair Steele   +5 more
wiley   +1 more source

Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation

Molecular Oncology, EarlyView.
How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim, Alvin Kunyao Guo, Yoko Itahana, Srinivasaraghavan Kannan, Valerie Goh, Mingmin Ong, Terina Yan Wen Tay, Weiying Ye, Sabhashina Radha Krishnan, Jun Nishiyama, Chandra S Verma, Koji Itahana   +11 more
wiley   +1 more source

Mahi-mahi metacouplings: quantifying human–nature interactions in dolphinfish (Coryphaena hippurus) fisheries

Global Sustainability
Non-Technical Summary Fisheries encompass humans and fish, but fisheries researchers rarely model human–nature interactions over space and time. I filled this information gap for dolphinfish (Coryphaena hippurus), a popular, widely distributed species ...
Andrew K. Carlson
doaj   +1 more source