Results 51 to 60 of about 12,389,112 (241)

Effects of human-animal relationship on animal productivity and welfare [PDF]

open access: yes, 2020
This is a literature review of the effects of humans´ relationships with farm animals on animal productivity and welfare, including the following topics: definition of the concept and description of different tests that have been developed to measure ...
Alonso-Spilsbury, María   +5 more
core   +1 more source

Design and analysis strategies for robust microbiome ageing research

open access: yesFEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik   +5 more
wiley   +1 more source

Human-Animal Interactions and Edibility? [PDF]

open access: yes
Does a growing pet-keeping culture affect other human-animal ...
Rowan, Andrew N
core   +2 more sources

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

open access: yesFEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens   +8 more
wiley   +1 more source

Understanding risk in human–animal interactions

open access: yesForced Migration Review, 2018
There needs to be better understanding not only of the importance of animals in the lives of displaced people but also of the potential risks incurred by human–animal interactions and how best to mitigate these risks.
Sara Owczarczak-Garstecka
doaj  

“Humaneness” and the capable animal: A proposal for a non-anthropocentric definition for the subjectivities and integrity of non-human animals

open access: yesHuman-Animal Interactions
“Truth is not born nor is it to be found inside the head of an individual person, it is born between people collectively searching for truth, in the process of their dialogic interaction” (Bakhtin, 1999, p. 110).
Kristen Cudmore, Cassandra Hanrahan
doaj   +1 more source

Reconstructing enzyme evolution by protein engineering

open access: yesFEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler   +2 more
wiley   +1 more source

Dynamics of human-ungulate interactions in a high-visitation alpine area

open access: yesHuman-Animal Interactions
Humans engaging in outdoor recreational activities can inadvertently introduce salts and minerals into natural environments, attracting wild ungulates to trails and parking areas, which increases the risk of disease transmission and negative human ...
Nichole L. Nageotte   +5 more
doaj   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

open access: yesFEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta   +3 more
wiley   +1 more source

Structure‐forward targeting of claudins with synthetic binders

open access: yesFEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

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