Results 81 to 90 of about 12,389,112 (241)

RNA‐related functions of BRCA2 in transcription, replication, and genome stability

FEBS Letters, EarlyView.
Beyond its role in homologous recombination, BRCA2 regulates R‐loop homeostasis, DNA–RNA hybrid resolution, RNA polymerase II dynamics, and transcriptional activation. Disruption of any of these functions can contribute to genome instability, inflammatory signaling, and tumorigenesis. BRCA2 is a central tumor suppressor protein best known for its roles
Lucia Alvaro‐Aranda, Sreerama Chaitanya Sridhara, Aura Carreira   +2 more
wiley   +1 more source

Compassionate end-of-life care: Development, implementation, and evaluation of a comprehensive euthanasia course in veterinary education from 2019–2024

Human-Animal Interactions
Background: End-of-life (EOL) and euthanasia best practices are vital but underrepresented areas in veterinary education. The Compassionate End-of-Life Care course at the Virginia-Maryland College of Veterinary Medicine (VMCVM) was developed to address ...
Virginia K. Corrigan, Kathleen Cooney, Raeann Foster   +2 more
doaj   +1 more source

Artificial molecular machines and motors—Design and control of nanoscale motion

FEBS Letters, EarlyView.
Molecules are constantly moving because of thermal fluctuations, but random motion alone cannot be exploited to perform directional tasks. Artificial molecular machines use chemical, electrical, or light energy to bias this motion. Molecular shuttles, rotary motors, and supramolecular pumps illustrate how nanoscale movement can be controlled and ...
Leonardo Andreoni, Alberto Credi
wiley   +1 more source

Editorial: Human-Animal Interactions in Prehistoric China

Frontiers in Earth Science, 2022
Shuangquan Zhang, Shuangquan Zhang, Manuel Domínguez-Rodrigo, Dongju Zhang, Yue Zhang, Yue Zhang   +5 more
doaj   +1 more source

Recommendations for uniform terminology in animal-assisted services (AAS)

Human-Animal Interactions
Through the years, the range of services involving animals benefiting people, often described as “animal-assisted interventions” (AAIs), has been plagued with confusing and inconsistent taxonomy, terminology, and definitions. This has caused difficulties
Amy Johnson Binder, Nancy Parish-Plass, Meg Kirby, Melissa Winkle, Daniela Plesa Skwerer, Laura Ackerman, Cindy Brosig, Wendy Coombe, Esther Delisle, Marie-Jose Enders-Slegers, Jo-Ann Fowler, Laura Hey, Tiffani Howell, Michael Kaufmann, Mariana Kienast, Miyako Kinoshita, Debbie Ngai, Brigitte Wijnen   +17 more
doaj   +1 more source

Leucine‐rich glioma inactivated 1 (LGI1) is a ganglioside‐binding protein

FEBS Letters, EarlyView.
Neuronal hyperexcitability associated with a decrease/absence of the extracellular protein LGI1 has been suggested to be primarily due to the downregulation of Kv1 channel expression. The molecular mechanisms underlying this decrease have not yet been elucidated.
Kévin Debreux, Christian Lévêque, Fodil Azzaz, Marion Sangiardi, Sarosh R Irani, Michael Seagar, Jacques Fantini, Oussama El Far   +7 more
wiley   +1 more source

Development and validation of the Companion Animals Self-Expansion Scale

Human-Animal Interactions
Although many people experience a close and complex relationship with their companion animals, our understanding and measurement of this relationship has lagged far behind that of human-human relationships.
Annalyse Ellis, Sarah C.E. Stanton, Roxanne D. Hawkins, Steve Loughnan   +3 more
doaj   +1 more source

The ubiquitin system in normal and infected germinal center B cells

FEBS Letters, EarlyView.
The ubiquitin system plays a central role in germinal center (GC) B cells, influencing differentiation to long‐lived memory B cells. Oncogenic gammaherpesviruses gain access to memory B cells by establishing latency in GC B cells. Mapping ubiquitin mechanisms in normal and infected GC B cells will define specific molecular circuits in B cells germane ...
Destiny Davis, Lesly Mejia, Emily K Moser   +2 more
wiley   +1 more source

Metastatic niche shaped by host factors influences disseminated cancer cell fate

FEBS Letters, EarlyView.
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward, Álvaro Ruiz‐Tabas, Patricia Altea‐Manzano   +2 more
wiley   +1 more source

Smaller is better: nanobodies meet NMR

FEBS Letters, EarlyView.
Nanobodies are single‐domain antigen‐binding fragments derived from camelid heavy chain antibodies. Their small size, high stability, and exceptional specificity make nanobodies uniquely useful probes for NMR studies of protein dynamics, transient conformational states, and protein–protein interactions.
Oleg Y. Dmitriev
wiley   +1 more source