Results 41 to 50 of about 14,818,924 (232)

A systematic evidence map of conservation knowledge in Chilean Patagonia

Conservation Science and Practice, 2022
Mechanisms that reliably and efficiently guide practitioners to find relevant evidence are urgent for conservation decision‐making in Chilean Patagonia. The objective of this study was to systematically collect, characterize, and synthesize the extensive
María José Martínez‐Harms, Juan J. Armesto, Juan Carlos Castilla, Anna Astorga, José Aylwin, Alejandro H. Buschmann, Victoria Castro, Giovanni Daneri, Miriam Fernández, Taryn Fuentes‐Castillo, Stefan Gelcich, Humberto E. González, Rodrigo Hucke‐Gaete, Pablo A. Marquet, Flavia Morello, Laura Nahuelhual, Patricio Pliscoff, Brian Reid, Ricardo Rozzi, Cesar Guala, David Tecklin   +20 more
doaj   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Weaving values, knowledge and context to care for human–nature relationships in protected areas [PDF]

Transformative change necessitates a profound shift in how people relate to, understand, value and envision landscapes to find effective pathways for conservation science and practice.
van Riper, Carena J., Goodson, Devin J., Raymond, Christopher M., Keller, Rose, Riper, Carena J., Plieninger, Tobias, Cebrian-Piqueras, Miguel A., Andrade, Riley, Raymond, Christopher,, Sveriges lantbruksuniversitet., Cebrián-Piqueras, Miguel Ángel, Swedish University of Agricultural Sciences., Raymond, Christopher M.,   +12 more
core   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Nurturing connection with nature: the role of spending time in different types of nature

Ecosystems and People, 2022
Connection with nature has been associated with greater participation in a range of biodiversity conservation behaviours, and is increasingly being recognised as a potentially useful policy tool to address conservation outcomes. Yet, understanding of how
Melissa Anne Hatty, Felix Tinoziva Mavondo, Denise Goodwin, Liam David Graham Smith   +3 more
doaj   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

More than food production: Assemblages of values underpinning women‐led agroecological initiatives

People and Nature
Agroecology advocates the transformation to sustainable agri‐food systems by renouncing production maximization and holistically integrating ecological and social aspects.
Beatriz Vizuete, Milena Gross, Marina García‐Llorente, Elisa Oteros‐Rozas, Berta Martín‐López   +4 more
doaj   +1 more source

Reviewing the relationship between neoliberal societies and nature: implications of the industrialized dominant social paradigm for a sustainable future

Ecology and Society, 2022
How a society relates to nature is shaped by the dominant social paradigm (DSP): a society’s collective view on social, economic, political, and environmental issues.
Jeanne M. Bogert, Jacintha Ellers, Stephan Lewandowsky, Meena M. Balgopal, Jeffrey A. Harvey   +4 more
doaj   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source