Results 111 to 120 of about 3,603,331 (295)

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

open access: yesMolecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta   +10 more
wiley   +1 more source

Investigating the Behavior and Personality Structure of the Aldabra Tortoise during Human Interactions and Training Events [PDF]

open access: gold, 2022
Giovanni Quintavalle Pastorino   +8 more
openalex   +1 more source

THE SCHOOL MANAGEMENT SUCCESS INVOLVED BY THE PARTNERSHIP WITH THE COMMUNITY [PDF]

open access: yes
The rigorous social organization of modern society ensures its maximum efficiency. Institutions and organizations structure people's daily life, regulate individual and collective behaviors, set rules for social and human interaction, regulate ...
Diana Mihaescu   +2 more
core  

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

open access: yesMolecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Interface-driven human brain injury mechanisms in blast exposure: A fluid–structure interaction model

open access: yesMedicine in Novel Technology and Devices
Blast-induced traumatic brain injury (bTBI) presents a significant challenge for military personnel and civilians exposed to explosions. Beyond combat, bTBI can arise from civilian incidents like industrial accidents (chemical-plant or mining blasts ...
Joseph Amponsah   +5 more
doaj   +1 more source

Revisiting the structure of the Vps10 domain of human sortilin and its interaction with neurotensin [PDF]

open access: bronze, 2014
E.M. Quistgaard   +8 more
openalex   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

open access: yesMolecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova   +25 more
wiley   +1 more source

A flexible telerobotic system for space operations [PDF]

open access: yes
The objective and design of a proposed goal-oriented knowledge-based telerobotic system for space operations is described. This design effort encompasses the elements of the system executive and user interface and the distribution and general structure ...
Sliwa, N. O., Will, R. W.
core   +1 more source

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