Results 201 to 210 of about 3,603,331 (295)

TCL1A mediates DNA methylation defects in recurrent hydatidiform mole with NLRP7 pathogenic variants. [PDF]

Nat Commun
Gao Z, Liu Q, Li L, Hu T, Lu X, Wu Y, Qin D, Wang X, Gu C, Li J, Xu C, Zhou D, Zhou F, Bai Y, Kang X, Liu J, Deng D, Li L.   +17 more
europepmc   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Insights into the structure and evolution of the human SAGA complex by affinity-ligand purification. [PDF]

Sci Adv
Damilot M, Schoeps T, Tora L, Schultz P, Lebeau L, Papai G, Ben-Shem A.   +6 more
europepmc   +1 more source

Intercompartmental communication in senescence

FEBS Open Bio, EarlyView.
Senescent cells experience structural changes in the plasma membrane, endoplasmic reticulum, mitochondria, lysosomes, nucleus, and cytoskeleton. These alterations disrupt crosstalk among cellular compartments, impairing vesicular trafficking, contact sites, and molecular flow.
Krystyna Mazan‐Mamczarz, Eleanor J. Wind, Jixiang Leng, Myriam Gorospe   +3 more
wiley   +1 more source

Repurposing AI for protein interactions and dynamics: opportunities, limitations, and lessons. [PDF]

Front Bioinform
Ozdemir ES, Jang H, Nussinov R, Gursoy A, Keskin O.   +4 more
europepmc   +1 more source

Erratum: Small-molecule interaction with a five-guanine-tract G-quadruplex structure from the human MYC promoter [PDF]

, 2005
Anh Tuân Phan, Vitaly Kuryavyi, Hai Yan Gaw, Dinshaw J. Patel   +3 more
openalex   +1 more source

Cutaneous Melanoma Drives Metabolic Changes in the Aged Bone Marrow Immune Microenvironment

Aging and Cancer, EarlyView.
Melanoma, the deadliest form of skin cancer, increasingly affects older adults. Our study reveals that melanoma induces changes in iron and lipid levels in the bone marrow, impacting immune cell populations and increasing susceptibility to ferroptosis.
Alexis E. Carey, Murilo Ramos Rocha, Cheyenne Palm, Vania Wang, Denys Balandin, Ethan Black, Kevin Y. Zhang, Fan Huang, Daniel J. Zabransky, Yash Chhabra, Mareike Peters, Gabriel Ghiaur, Ashani Weeraratna   +12 more
wiley   +1 more source

Hydrophobic interactions determine the optimum temperature of a housekeeping enzyme. [PDF]

J Biol Chem
Yamamoto T, Shiraishi A, Sakai T, Wada A, Satake H.   +4 more
europepmc   +1 more source

A peptide mimic of an antigenic loop of α-human chorionic gonadotropin hormone: solution structure and interaction with a llama VHH domain

, 2002
Gilles Ferrat, Jean‐Guillaume Renisio, Xavier Morelli, Jerry W. Slootstra, Rob H. Meloen, Christian Cambillau, Hervé Darbon   +6 more
openalex   +2 more sources

Natural Products as Geroprotective Modulators in Diabetic Nephropathy: A Mechanistic Framework Integrating Aging Hallmarks and the AMPK–SIRT1–Nrf2 Axis

Aging and Cancer, EarlyView.
Natural products target the aging kidney in diabetic nephropathy by restoring the AMPK–SIRT1–Nrf2 axis, reducing oxidative stress, inflammation, fibrosis, and cellular senescence while enhancing mitochondrial biogenesis and antioxidant defenses.
Sherif Hamidu, Latif Adams, Eunice Ampem‐Danso, Justice Kumi, Abigail Aning, Fatima Hamidu, Mustapha Abdul Mumin Mohammed, Ayuba Nii Darku Ankrah, Seth Kwabena Amponsah   +8 more
wiley   +1 more source