Results 51 to 60 of about 1,764,727 (264)

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Human-Structure Dynamic Interaction during Short-Distance Free Falls

Shock and Vibration, 2016
The dynamic interactions of falling human bodies with civil structures, regardless of their potentially critical effects, have sparsely been researched in contact biomechanics.
E. Shahabpoor, A. Pavic
doaj   +1 more source

Effects of human-structure interaction in slabs [PDF]

, 2014
During the last several decades, stronger and lighter materials have been developed with the aim of optimizing performance and building costs. These technological advances have given rise to thin flexible flooring systems with natural frequencies that ...
Villamizar, Sandra, Gómez, Daniel, Thomson, Peter   +2 more
core  

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

FEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes, Jan Brysch, Carmen Gelze, Lilli Meier, Daniel Kümmel   +4 more
wiley   +1 more source

Data-driven models for human–structure interaction based on MLP and NARX neural networks

Frontiers in Built Environment
Structural design often neglects the dynamic effects induced by human activities. Excessive vibrations in structures such as pedestrian bridges, grandstands, slabs, and stairways have highlighted the analysis as dynamic systems of humans interacting with
Daniel Mena-Sanchez, Natividad Garcia-Troncoso, Natividad Garcia-Troncoso, Wilfredo Alfonso, Albert R. Ortiz, Daniel Gomez   +5 more
doaj   +1 more source

Study on Human-structure Dynamic Interaction in Civil Engineering

E3S Web of Conferences, 2018
The research of human-structure dynamic interaction are reviewed. Firstly, the influence of the crowd load on structural dynamic characteristics is introduced and the advantages and disadvantages of different crowd load models are analyzed.
Gao Feng, Cao Li Lin, Li Xing Hua
doaj   +1 more source

Optimization of a Human-Powered Aircraft Using Fluid–Structure Interaction Simulations

Aerospace, 2016
The special type of aircrafts in which the human power of the pilot is sufficient to take off and sustain flight are known as Human-Powered Aircrafts (HPAs).
Bob Vanderhoydonck, Gilberto Santo, Jan Vierendeels, Joris Degroote   +3 more
doaj   +1 more source

Molecular Insights to the Structure-Interaction Relationships of Human Proton-Coupled Oligopeptide Transporters (PepTs)

Pharmaceutics, 2023
Human proton-coupled oligopeptide transporters (PepTs) are important membrane influx transporters that facilitate the cellular uptake of many drugs including ACE inhibitors and antibiotics.
Yining Luo, Jingchun Gao, Xukai Jiang, Ling Zhu, Qi Tony Zhou, Michael Murray, Jian Li, Fanfan Zhou   +7 more
doaj   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source