Results 81 to 90 of about 18,350,585 (254)

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Modeling of Complex Human-Process-Interaction as Framework for Assistance and Supervisory Control of Technical Processes

, 2012
Interactive processes are omnipresent in research fields dealing with automation of complex technical processes. Such research fields allow a wide range of application scenarios of assistance systems to support human operators.
Söffker, Dirk, Hasselberg, Andreas, Fu, Xingguang, Langer, Marcel   +3 more
core   +1 more source

Integrating feedback control for improved human-structure interaction analysis

Frontiers in Built Environment
The human body, composed of interconnected subsystems with complex dynamic behavior, is often oversimplified or neglected by structural designers and building codes. Human-induced loads, whether passive (e.g., standing, sitting) or active (e.g., walking,
Santiago A. Lopez, Daniel Gomez, Albert R. Ortiz, Sandra Villamizar   +3 more
doaj   +1 more source

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source

Human Models for Human-Robot Interaction [PDF]

, 2011
This paper discusses various human models required in human-robot interaction study. Good human models are critical for robots to realize effective interactions.
Yamane, Katsu
core   +1 more source

Human interaction with structure in designing big data architecture

South African Journal of Information Management
Background: There is an increasing interest in big data. However, challenges shape and affect the gathering, retrieval, use and management of big data in many organisations.
Wandisa Nyikana, Tiko Iyamu
doaj   +1 more source

Interaction of Cholesterol With the Human SLC1A5 (ASCT2): Insights Into Structure/Function Relationships

Frontiers in Molecular Biosciences, 2019
The human SLC1A5 commonly known as ASCT2 is a sodium-dependent neutral amino acid antiporter involved in transmembrane traffic of glutamine that is exchanged through the cell membrane with smaller amino acids such as serine or threonine.
Mariafrancesca Scalise, Lorena Pochini, Jessica Cosco, Emma Aloe, Tiziano Mazza, Lara Console, Antonella Esposito, Cesare Indiveri   +7 more
doaj   +1 more source

Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding

FEBS Letters, EarlyView.
In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança, Eline L. Jansen, Jorine M. Eeftens   +2 more
wiley   +1 more source

Translophagy—A potential link between autophagy impairment and translational errors

FEBS Letters, EarlyView.
Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk, Gailing Ma, Robin Antrobus, Diego Manni, Marco Trevisan‐Herraz, Mustafa Khwaja, Max Brown, Gavin D. Richardson, Masaaki Komatsu, Daniel Erskine, Viktor I. Korolchuk, Tetsushi Kataura   +11 more
wiley   +1 more source

Subjective Evaluation of Generative AI-Driven Dialogues in Paired Dyadic and Topic-Sharing Triadic Interaction Structures

Applied Sciences
As the linguistic capabilities of dialogue systems improve, the importance of how they interact with humans and build trustworthy relationships is increasing. This study investigated the effect of interaction structures in a generative AI-driven dialogue
Kaori Abe, Changqin Quan, Sheng Cao, Zhiwei Luo   +3 more
doaj   +1 more source