Results 121 to 130 of about 503,408 (307)
The biology of the human–animal bond
Animal Frontiers, 2014 Our relationship with domestic animals is rooted in evolutionary, psychological, and physiological processes. There are significant health benefits for people associated with their interaction with animals. There are significant health benefits for animals associated with their interaction with people. Animals can be effectively utilized in therapeutic
openaire +1 more source
Recovery of “Intrinsic Value” Damages in Case of Negligently Killed Pet Dog [PDF]
, 2012 The North Carolina Court of Appeals, in a case where negligent killing of a pet dog with no market value was admitted, has denied recovery of “intrinsic” damages (also called “actual” damages). Shera v.
Gerber, Calley, Reppy, William A., Jr.
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Molecular Oncology, EarlyView.Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee +8 more
wiley +1 more source
European Journal of Investigation in Health, Psychology and EducationEmotional dysregulation involving anger can have severe consequences on the individual’s psychosocial and emotional functioning. This study aimed to investigate the role that the companion animal bond and the personality dimension of trait anger play in ...
Vincenzo Bochicchio +5 more
doaj +1 more source
Tumor mutational burden as a determinant of metastatic dissemination patterns
Molecular Oncology, EarlyView.This study performed a comprehensive analysis of genomic data to elucidate whether metastasis in certain organs share genetic characteristics regardless of cancer type. No robust mutational patterns were identified across different metastatic locations and cancer types.
Eduardo Candeal +4 more
wiley +1 more source
Merging: Contemplations on Farming & Ecology from Horseback by Soren Bondrup-Nielsen [PDF]
, 2015 Anna Banks reviews Merging: Contemplations on Farming & Ecology from Horseback, by Soren Bondrup ...
Banks, Anna
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Molecular Oncology, EarlyView.Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat +8 more
wiley +1 more source
AnimalsAlthough many companion animal (or “pet”) owners report that their relationships with their pets are important, we know little about how animal ownership duration and animal life stage are related to relationship quality.
Annalyse Ellis +3 more
doaj +1 more source
Targeting p38α in cancer: challenges, opportunities, and emerging strategies
Molecular Oncology, EarlyView.p38α normally regulates cellular stress responses and homeostasis and suppresses malignant transformation. In cancer, however, p38α is co‐opted to drive context‐dependent proliferation and dissemination. p38α also supports key functions in cells of the tumor microenvironment, including fibroblasts, myeloid cells, and T lymphocytes.
Angel R. Nebreda
wiley +1 more source
Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer
Molecular Oncology, EarlyView.PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta +10 more
wiley +1 more source