Molecular Oncology, EarlyView.A comprehensive genomic and proteomic analysis of cervical cancer revealed STK11 and STX3 as a potential biomarkers of chemoradiation resistance. Our study demonstrated EGFR as a therapeutic target, paving the way for precision strategies to overcome treatment failure and the DNA repair pathway as a critical mechanism of resistance.
Janani Sambath +13 more
wiley +1 more source
Late Pleistocene shell midden microstratigraphy indicates a complex history of human-environment interactions in the uplands of North Vietnam. [PDF]
Philos Trans R Soc Lond B Biol Sci, 2022 McAdams C +7 more
europepmc +1 more source
Toward a Science of Sustainability [PDF]
, 2012 This report presents an overview of research horizons in sustainability science. Its motivation is to help harness science and technology to foster a transition toward sustainability – toward patterns of development that promote human well-being while ...
Clark, William C., Levin, Simon A.
core
YAP1::TFE3 mediates endothelial‐to‐mesenchymal plasticity in epithelioid hemangioendothelioma
Molecular Oncology, EarlyView.The YAP1::TFE3 fusion protein drives endothelial‐to‐mesenchymal transition (EndMT) plasticity, resulting in the loss of endothelial characteristics and gain of mesenchymal‐like properties, including resistance to anoikis, increased migratory capacity, and loss of contact growth inhibition in endothelial cells.
Ant Murphy +9 more
wiley +1 more source
Waypoints on a Journey of Discovery: Mental Models in Human-Environment Interactions
Ecology and Society, 2012 Although the broad concept of mental models is gaining currency as a way to explore the link between how people think and interact with their world, this concept is limited by a theoretical and practical understanding of how it can be applied in the ...
Timothy Lynam +10 more
doaj +1 more source
Making the invisible visible: New perspectives on the intersection of human-environment interactions of clinical teams in intensive care. [PDF]
J Perinatol, 2022 Visram S +6 more
europepmc +1 more source
Towards the environmental geography concept [PDF]
, 2014 Authors introduce the environmental geography concept. Environmental geography describes the spatial aspects of interactions between the human society and the natural environment.
Костріков, С.В. +1 more
core
Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids
Molecular Oncology, EarlyView.This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici +8 more
wiley +1 more source
Geospatial Health, 2018 Quantitative data on human-environment interactions are needed to fully understand infectious disease transmission processes and conduct accurate risk assessments.
Timothy R. Julian +6 more
doaj +1 more source
Disentangling the last 1,000 years of human-environment interactions along the eastern side of the southern Andes (34-52°S lat.). [PDF]
Proc Natl Acad Sci U S A, 2022 Nanavati W +5 more
europepmc +1 more source