Results 101 to 110 of about 2,797,343 (294)

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

Late Pleistocene shell midden microstratigraphy indicates a complex history of human-environment interactions in the uplands of North Vietnam. [PDF]

Philos Trans R Soc Lond B Biol Sci, 2022
McAdams C, Morley MW, Fu X, Kandyba AV, Derevianko AP, Nguyen DT, Doi NG, Roberts RG.   +7 more
europepmc   +1 more source

Evaluating human performance modeling for system assessment: Promise and problems [PDF]

The development and evaluation of computational human performance models is examined. An intention is to develop models which can be used to interact with system prototypes and simulations to perform system assessment. Currently LR is working on a set of
Patterson, Robert W., Young, Michael J.
core   +1 more source

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Waypoints on a Journey of Discovery: Mental Models in Human-Environment Interactions

Ecology and Society, 2012
Although the broad concept of mental models is gaining currency as a way to explore the link between how people think and interact with their world, this concept is limited by a theoretical and practical understanding of how it can be applied in the ...
Timothy Lynam, Raphael Mathevet, Michel Etienne, Samantha Stone-Jovicich, Anne Leitch, Nathalie Jones, Helen Ross, Derick Du Toit, Sharon Pollard, Harry Biggs, Pascal Perez   +10 more
doaj   +1 more source

Making the invisible visible: New perspectives on the intersection of human-environment interactions of clinical teams in intensive care. [PDF]

J Perinatol, 2022
Visram S, Potts L, Sebire NJ, Rogers Y, Broughton E, Chigaru L, Nambyiah P.   +6 more
europepmc   +1 more source

Toward a Science of Sustainability [PDF]

, 2012
This report presents an overview of research horizons in sustainability science. Its motivation is to help harness science and technology to foster a transition toward sustainability – toward patterns of development that promote human well-being while ...
Clark, William C., Levin, Simon A.
core  

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Quantifying human-environment interactions using videography in the context of infectious disease transmission

Geospatial Health, 2018
Quantitative data on human-environment interactions are needed to fully understand infectious disease transmission processes and conduct accurate risk assessments.
Timothy R. Julian, Carla Bustos, Laura H. Kwong, Alejandro D. Badilla, Julia Lee, Heather N. Bischel, Robert A. Canales   +6 more
doaj   +1 more source

Disentangling the last 1,000 years of human-environment interactions along the eastern side of the southern Andes (34-52°S lat.). [PDF]

Proc Natl Acad Sci U S A, 2022
Nanavati W, Whitlock C, de Porras ME, Gil A, Navarro D, Neme G.   +5 more
europepmc   +1 more source