Results 71 to 80 of about 2,796,361 (294)
, 2017 Here we reveal details of the interaction between human lysozyme proteins, both native and fibrils, and their water environment by intense terahertz time domain spectroscopy.
Appadoo, Dominique R. T. +6 more
core +1 more source
Vision systems with the human in the loop [PDF]
, 2005 The emerging cognitive vision paradigm deals with vision systems that apply machine learning and automatic reasoning in order to learn from what they perceive.
Bauckhage, Christian +5 more
core +4 more sources
Molecular bases of circadian magnesium rhythms across eukaryotes
FEBS Letters, EarlyView.Circadian rhythms in intracellular [Mg2+] exist across eukaryotic kingdoms. Central roles for Mg2+ in metabolism suggest that Mg2+ rhythms could regulate daily cellular energy and metabolism. In this Perspective paper, we propose that ancestral prokaryotic transport proteins could be responsible for mediating Mg2+ rhythms and posit a feedback model ...
Helen K. Feord, Gerben van Ooijen
wiley +1 more source
Multiple telecouplings and their complex interrelationships
Ecology and Society, 2015 Increasingly, the world is becoming socioeconomically and environmentally connected, but many studies have focused on human-environment interactions within a particular area. Although some studies have considered the impacts of external factors, there is
Jianguo Liu +15 more
doaj +1 more source
Human-Smart Environment Interactions in Smart Cities: Exploring Dimensionalities of Smartness
Future Internet, 2020 In the context of the challenges facing human computer interaction (HCI) on the one hand and the future Internet on the other, the purpose of this study is to explore the multi-dimensionality of smart cities, looking at relationships and ...
H. Patricia McKenna
doaj +1 more source
The digital skin of cities: urban theory and research in the age of the sensored and metered city, ubiquitous computing and big data [PDF]
, 2015 A ‘digital skin’ of the city is coming into being. This skin consists of a sensored and metered urban environment. The urban world is becoming a platform for generating data on the workings of human society, human interactions with the physical ...
Rabari, Chirag, Storper, Michael
core +1 more source
Peptide‐based ligand antagonists block a Vibrio cholerae adhesin
FEBS Letters, EarlyView.The structure of a peptide‐binding domain of the Vibrio cholerae adhesin FrhA was solved by X‐ray crystallography, revealing how the inhibitory peptide AGYTD binds tightly at its Ca2+‐coordinated pocket. Structure‐guided design incorporating D‐amino acids enhanced binding affinity, providing a foundation for developing anti‐adhesion therapeutics ...
Mingyu Wang +9 more
wiley +1 more source
Global goals mapping: the environment-human landscape [PDF]
, 2017 The UK Natural Environment Research Council (NERC), The Rockefeller Foundation (RF), and the UK Economic and Social Research Council (ESRC) recognise that the development challenges of the 21st century require both a shift in thinking and actions that ...
Balfour, Nicholas +10 more
core
FEBS Letters, EarlyView.This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley +1 more source
Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing
FEBS Letters, EarlyView.Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley +1 more source