Results 71 to 80 of about 2,797,343 (294)

Determinants of access patterns to goods and services from wetlands in Tanzania and the impact on sustainable wetland management [PDF]

, 2012
Wetlands perform vital role in providing useful goods and services to mankind. Because of their importance, human beings interactions with the wetlands’ physical environment have caused some of them to be highly degraded.
Hella, Joseph, Kessy, John, Mombo, Felister Michael, Speelman, Stijn, Van Huylenbroeck, Guido   +4 more
core   +2 more sources

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

Dot-to-Dot: Explainable Hierarchical Reinforcement Learning for Robotic Manipulation

, 2019
Robotic systems are ever more capable of automation and fulfilment of complex tasks, particularly with reliance on recent advances in intelligent systems, deep learning and artificial intelligence.
Beyret, Benjamin, Faisal, A. Aldo, Shafti, Ali   +2 more
core   +1 more source

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Multiple telecouplings and their complex interrelationships

Ecology and Society, 2015
Increasingly, the world is becoming socioeconomically and environmentally connected, but many studies have focused on human-environment interactions within a particular area. Although some studies have considered the impacts of external factors, there is
Jianguo Liu, Vanessa Hull, Junyan Luo, Wu Yang, Wei Liu, Andrés Viña, Christine Vogt, Zhenci Xu, Hongbo Yang, Jindong Zhang, Li An, Xiaodong Chen, Shuxin Li, Zhiyun Ouyang, Weihua Xu, Hemin Zhang   +15 more
doaj   +1 more source

Human-Smart Environment Interactions in Smart Cities: Exploring Dimensionalities of Smartness

Future Internet, 2020
In the context of the challenges facing human computer interaction (HCI) on the one hand and the future Internet on the other, the purpose of this study is to explore the multi-dimensionality of smart cities, looking at relationships and ...
H. Patricia McKenna
doaj   +1 more source

River archaeology – a new tool for historical hydrology [PDF]

, 2008
River archaeology is consisting of underwater research of the rivers themselves, and also the archaeology of the valleys/floodplains with special interest in humanenvironmental interactions (reconstructing space, environment, economy and society on ...
Tóth, János Attila
core   +1 more source

Mechanisms of IgE‐mediated food allergy and the role of allergen‐specific B cells

FEBS Letters, EarlyView.
Food allergy arises when allergen‐specific B cells preferentially produce immunoglobulin E (IgE) antibodies against harmless foods. This article explains the mechanisms driving IgE‐mediated reactions, highlights the central role of these B cells, and discusses how natural tolerance (NT) and oral immunotherapy (OIT) can reshape allergic immune responses.
Juan‐Felipe López, Özge Yilmaz Ardicli, Mübeccel Akdis   +2 more
wiley   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source