Results 101 to 110 of about 109,968,647 (310)
, 2020 Sequences used in creating the multiple sequence alignment and their BLAST scores using the mRNA from the human basic helix-loop-helix family member e41 as the query.
Justen B. Whittall (7867217) +1 more
core +1 more source
The double loop mattress suture [PDF]
, 2014 © 2014 The Authors http://creativecommons.org/licenses/by/3.0/ An interrupted stitch type with favorable tissue characteristics will reduce local wound complications.
Biddlestone, John +3 more
core +1 more source
Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer
Molecular Oncology, EarlyView.Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley +1 more source
Sophie Doulut, "From the Barbican to the Colony"
On English Plymouth harbour, there’s a gateway, The sky is framed within an invisible door Seagulls flitter through it and away, The way the Pilgrim Fathers walked through it before. A few yards away, the list of passengers reads On the stone walls of
The LOOP team
core +1 more source
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
Human-in-the-Loop Parsing [PDF]
Proceedings of the 2016 Conference on Empirical Methods in Natural
Language Processing, 2016 Luheng He +3 more
openaire +1 more source
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Statistical Shape Models for Grasp Point Determination in Laparoscopic Surgeries
Current Directions in Biomedical EngineeringRobotic assistance systems are being used more and more frequently in the operating room, with the goal to support surgeons and to automate parts of a procedure.
Kunz Christian +4 more
doaj +1 more source
Molecular Oncology, EarlyView.Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller +10 more
wiley +1 more source