Results 71 to 80 of about 156,269,237 (277)

An outer membrane vesicle‐associated two‐track model for enterotoxigenic Bacteroides fragilis oncogenesis

Molecular Oncology, EarlyView.
Enterotoxigenic Bacteroides fragilis is a gut bacterium linked to bowel cancer. We propose that its toxin acts along two routes: at the cell surface, cutting the adhesion protein E‐cadherin and triggering inflammation; and inside the cell, delivered by bacterial vesicles, switching on NOD1 and cancer stem cell programs.
Kangchan Choi, Sang‐Hyeon Yoo, Ki‐Jong Rhee   +2 more
wiley   +1 more source

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

FEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz, Bart Geverts, Johan A. Slotman, Andrea Sacchetti, Stefan Prekovic, Martin E. van Royen, Adriaan B. Houtsmuller   +6 more
wiley   +1 more source

User-Adaptive Variable Impedance Control Using Bayesian Optimization for Robot-Aided Ankle Rehabilitation

IEEE Transactions on Neural Systems and Rehabilitation Engineering
This paper presents a user-adaptive variable impedance control approach for robot-aided rehabilitation, initially focusing on an ankle rehabilitation application.
Gautham Manoharan, Hyunglae Lee
doaj   +1 more source

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

Human-in-the-Loop Optimization of the Stiffness and Alignment of a Prosthetic Foot to Reduce the Metabolic Cost of Walking

IEEE Transactions on Neural Systems and Rehabilitation Engineering
Improper tuning of prosthetic foot properties to the individual user limits the efficacy of current state-of-the-art prosthetic feet in terms of walking economy.
Thijs Tankink, Han Houdijk, Johnnidel Tabucol, Marco Leopaldi, Juha M. Hijmans, Raffaella Carloni   +5 more
doaj   +1 more source

Treatment with KCL‐286, a first‐in‐class retinoic acid receptor‐β (RARβ) agonist, ameliorates neuronal DNA damage and inflammation in a mouse model of Alzheimer's disease

FEBS Open Bio, EarlyView.
Repair of neuronal DNA damage in Alzheimer's disease by KCL‐286. (A) Amyloid‐β oligomers and plaques impair neuronal DNA repair pathways, leading to DNA double‐strand breaks and glial activation. (B) KCL‐286 activates RARβ/RXR signalling via retinoic acid response elements (RAREs), associated with increased BRCA1 expression, enhanced DNA repair and ...
Natasha Hill, Hassan Yousef Othman AlMuallim, Elouisa Maddock, Carl Hobbs, Earl Clarke, Maria B. Goncalves, Jonathan P. T. Corcoran   +6 more
wiley   +1 more source

Loop-Wise Route Representation and Its Optimization Formulation for Symmetric Traveling Salesman Problems

, 2023
This study proposes a new loop-wise route representation in which a vehicle route is represented in terms of continuous loop variables and a base route.
Hyunwoo Jin, Kim, Geunu, Kim, Mingi, Jin, Hyunwoo, In Gwun Jang, Jang, Kitae, Jang, In Gwun, Mingi Kim, Geunu Kim, Kitae Jang   +9 more
core   +1 more source

Yeast Gcn2 retains activity following humanization of its auto‐phosphorylation region

FEBS Open Bio, EarlyView.
Using Saccharomyces cerevisiae as a model to study Gcn2 activation and regulation is limited by the lack of antibodies detecting phosphorylated Gcn2. To overcome this, we engineered Gcn2‐HsC, a yeast Gcn2 variant recognizable by commercial anti‐human phospho‐GCN2 antibodies.
Reuben A. Anderson, Anja H. Schiemann, Evelyn Sattlegger   +2 more
wiley   +1 more source

Wearable Robot Design Optimization Using Closed-Form Human–Robot Dynamic Interaction Model

Sensors
Wearable robots are emerging as a viable and effective solution for assisting and enabling people who suffer from balance and mobility disorders.
Erfan Shahabpoor, Bethany Gray, Andrew Plummer   +2 more
doaj   +1 more source

Modules of the architecture of the robotic module ecosystem with human-in-the-loop.

, 2022
Modules of the architecture of the robotic module ecosystem with human-in-the-loop.
Abdulhamit Donder (13982750), Thomas Watts (372454), Riccardo Secoli (744404), Davide Danilo Zani (7504991), Eloise Matheson (13982741), Lorenzo Bello (238524), Marlene Pinzi (13982744), Stefano Galvan (13982747), Marco Riva (3162360), Ferdinando Rodriguez y Baena (7062113)   +9 more
core   +1 more source