Results 61 to 70 of about 15,477,856 (268)

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Urgent Biophilia: Human-Nature Interactions and Biological Attractions in Disaster Resilience

Ecology and Society, 2012
This contribution builds upon contemporary work on principles of biological attraction as well as earlier work on biophilia while synthesizing literatures on restorative environments, community-based ecological restoration, and both community and social ...
Keith G. Tidball
doaj   +1 more source

Resilience of human-nature interaction network to pandemic conditions

Science of The Total Environment
Cultural ecosystem services (CES) contribute to maintaining and improving human well-being. Understanding the network of interactions involved in co-producing CES is essential for maximizing well-being. In this study, we used social media data to estimate a CES network and assess human-nature interactions underpinning CES co-production.
Linder, Anne Cathrine, Lusseau, David; id_orcid 0000-0003-1245-3747   +1 more
openaire   +3 more sources

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source

Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding

FEBS Letters, EarlyView.
In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança, Eline L. Jansen, Jorine M. Eeftens   +2 more
wiley   +1 more source

One tree matters: reflections on data as a design material in urban forestry

Frontiers in Human Dynamics
This exploratory study explores the potential contexts and opportunities for emerging visual data in urban forest design. Forestry experts deploy drone-mounted digital sensors to capture detailed visual and spatial data urban vegetation.
Angela Rout, Sophie Nitoslawski, Lorien Nesbitt   +2 more
doaj   +1 more source

Structural and biochemical analysis of a B12 superbinder

FEBS Letters, EarlyView.
BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices, Jacob J. Whittaker, Dirk J. Slotboom, Albert Guskov   +3 more
wiley   +1 more source

Personalised ecology and detection functions

People and Nature, 2020
Direct interactions with nature are important for people's health, well‐being and support for pro‐nature policies. There is an urgent need better to understand the structure and dynamics of these interactions, and how they differ among individual people,
Kevin J. Gaston
doaj   +1 more source

Assessing human well‐being constructs with environmental and equity aspects: A review of the landscape

People and Nature, 2023
Decades of theory and scholarship on the concept of human well‐being have informed a proliferation of approaches to assess well‐being and support public policy aimed at sustainability and improving quality of life.
Erin C. Betley, Amanda Sigouin, Pua’ala Pascua, Samantha H. Cheng, Kenneth Iain MacDonald, Felicity Arengo, Yildiz Aumeeruddy‐Thomas, Sophie Caillon, Marney E. Isaac, Stacy D. Jupiter, Alexander Mawyer, Manuel Mejia, Alexandria C. Moore, Delphine Renard, Lea Sébastien, Nadav Gazit, Eleanor J. Sterling   +16 more
doaj   +1 more source

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

FEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source