Results 111 to 120 of about 17,735,654 (311)

Peptide‐based ligand antagonists block a Vibrio cholerae adhesin

FEBS Letters, EarlyView.
The structure of a peptide‐binding domain of the Vibrio cholerae adhesin FrhA was solved by X‐ray crystallography, revealing how the inhibitory peptide AGYTD binds tightly at its Ca2+‐coordinated pocket. Structure‐guided design incorporating D‐amino acids enhanced binding affinity, providing a foundation for developing anti‐adhesion therapeutics ...
Mingyu Wang, Grace Du, Charity Yongo‐Luwawa, Angelina Lu, Brett Kinrade, Kim Munro, Karl E. Klose, William D. Lubell, Peter Davies, Shuaiqi Guo   +9 more
wiley   +1 more source

Past, Present, and Future: Editorial on Virtual Reality Applications to Human Services [PDF]

, 2019
Mark H. Trahan, Kenneth Smith, Thomas B. Talbot   +2 more
openalex   +1 more source

Improving the regulatory environmental risk assessment of human pharmaceuticals: Required changes in the new legislation

, 2023
Daniela Gildemeister, Caroline Moermond, Cecilia Berg, Ulrika Bergström, Lucie Bielská, Maria Grazia Evandri, Marco Franceschin, Boris Kolar, Mark Montforts, Christine Vaculik   +9 more
openalex   +1 more source

Interplay between circadian and other transcription factors—Implications for cycling transcriptome reprogramming

FEBS Letters, EarlyView.
This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley   +1 more source

TRAF6 mediates human DNA2 polyubiquitination and nuclear localization to maintain nuclear genome integrity [PDF]

, 2019
Yuan Meng, Changwei Liu, Lei Shen, Mian Zhou, Wenpeng Liu, Claudia Kowolik, Judith L. Campbell, Li Zheng, Binghui Shen   +8 more
openalex   +1 more source

Influence of donor age and comorbidities on transduced human adipose-derived stem cell in vitro osteogenic potential [PDF]

, 2022
Kevin Collon, Jennifer A. Bell, Matthew C. Gallo, Stephanie W. Chang, Sofia Bougioukli, Osamu Sugiyama, Jade Tassey, Roger P. Hollis, Nathanael D. Heckmann, Daniel A. Oakes, Donald B. Longjohn, Denis Evseenko, Donald B. Kohn, Jay R. Lieberman   +13 more
openalex   +1 more source

International System for Human Cytogenetic Nomenclature

Definitions, 2020

semanticscholar   +1 more source

The role of histone modifications in transcription regulation upon DNA damage

FEBS Letters, EarlyView.
This review discusses the critical role of histone modifications in regulating gene expression during the DNA damage response (DDR). By modulating chromatin structure and recruiting repair factors, these post‐translational modifications fine‐tune transcriptional programmes to maintain genomic stability.
Angelina Job Kolady, Siyao Wang
wiley   +1 more source

Comparing self‐reported race and genetic ancestry for identifying potential differentially methylated sites in endometrial cancer: insights from African ancestry proportions using machine learning models

Molecular Oncology, EarlyView.
Integrating ancestry, differential methylation analysis, and machine learning, we identified robust epigenetic signature genes (ESGs) and Core‐ESGs in Black and White women with endometrial cancer. Core‐ESGs (namely APOBEC1 and PLEKHG5) methylation levels were significantly associated with survival, with tumors from high African ancestry (THA) showing ...
Huma Asif, J. Julie Kim
wiley   +1 more source

A large‐scale retrospective study in metastatic breast cancer patients using circulating tumour DNA and machine learning to predict treatment outcome and progression‐free survival

Molecular Oncology, EarlyView.
There is an unmet need in metastatic breast cancer patients to monitor therapy response in real time. In this study, we show how a noninvasive and affordable strategy based on sequencing of plasma samples with longitudinal tracking of tumour fraction paired with a statistical model provides valuable information on treatment response in advance of the ...
Emma J. Beddowes, Mario Ortega Duran, Solon Karapanagiotis, Alistair Martin, Meiling Gao, Riccardo Masina, Ramona Woitek, James Tanner, Fleur Tippin, Justine Kane, Jonathan Lay, Anja Brouwer, Stephen‐John Sammut, Suet‐Feung Chin, Davina Gale, Dana W. Y. Tsui, Sarah‐Jane Dawson, Nitzan Rosenfeld, Maurizio Callari, Oscar M. Rueda, Carlos Caldas   +20 more
wiley   +1 more source