Results 111 to 120 of about 21,797,798 (309)

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

FEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas, Porter L. Tomsick, Alicia M. Pickrell, Paul D. Morton   +3 more
wiley   +1 more source

Human Prosperity Measurement Within the Gloom of Maqasid Al-Shariah [PDF]

, 2019
This study is trying to interpret the theory of Maqasid Al-Shariah in wide context, which further based on the measurement of socio-economic prosperity; it takes into account the major drawbacks of the existing measurements.
Shabbir, M. S. (Malik)
core  

The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes

FEBS Letters, EarlyView.
Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga, Toshiki Takahashi, Akiko Kuma, Hiroyuki Kawahara   +3 more
wiley   +1 more source

The relationship between attachment, primary emotions and positive/negative spirituality: a path analysis

Frontiers in Public Health
ObjectiveThe present study investigates what may influence individuals to experience their religiosity/spirituality as either subjectively positive [religious or spiritual (r/s) wellbeing] or as negative (r/s struggles).
Anton Freund, Jürgen Fuchshuber, Jürgen Fuchshuber, Jürgen Fuchshuber, Giorgia Silani, Human-Friedrich Unterrainer, Human-Friedrich Unterrainer, Human-Friedrich Unterrainer, Human-Friedrich Unterrainer, Human-Friedrich Unterrainer   +9 more
doaj   +1 more source

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

FEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source

Anxious and depressive symptoms mediate the influence of sleep quality on suicidality in young adults

Frontiers in Public Health
This study investigated how sleep quality affects the global severity of psychiatric symptoms, including suicidality, in young adults. Poor sleep quality has a significant impact on mental health and should therefore be given special attention in ...
Corinna Slanitz, Corinna Slanitz, Jürgen Fuchshuber, Jürgen Fuchshuber, Andreas Fink, Human-Friedrich Unterrainer, Human-Friedrich Unterrainer, Human-Friedrich Unterrainer, Human-Friedrich Unterrainer, Human-Friedrich Unterrainer   +9 more
doaj   +1 more source

Work-Family Conflict Not Just a Women\u27s Issue: Helping All Employees Find Work-Life Balance [PDF]

, 2010
KEY FINDINGS * If employees feel their family life interferes with their work, they tend to feel guilty. They\u27re actually less likely to feel guilt when they feel work interferes with their family life, possibly because it\u27s increasingly acceptable
Center for Advanced Human Resource Studies, ILR School, Cornell University
core   +1 more source

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

Molecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang, Qian Sun, Daniel Novak, Lei Zhu, Juliane Poelchen, Tamara Steinfass, Yiman Wang, Viktor Umansky, Jochen Utikal   +8 more
wiley   +1 more source

Customers Suffer From Employee Churn: High Turnover Makes It Harder to Provide Top Service [PDF]

, 2009
Key Findings: • As rates of voluntary turnover climb within key business units, customers are more likely to report bad customer service. • When new workers arrive, established workers have to take time away from customer service to train the
Center for Advanced Human Resource Studies, ILR School, Cornell University.
core   +1 more source